Physiology and Pathophysiology of Neuromuscular Transmission
Physiology and Pathophysiology of Neuromuscular Transmission
Physiology and Pathophysiology of Neuromuscular Transmission
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Lambert-Eaton Myasthenic Syndrome<br />
• Weight loss<br />
• Slurred speech<br />
• Weak shoulder abduction <strong>and</strong> hip flexion<br />
• Reflexes absent, but re-appear after exercise<br />
• Sensation normal<br />
Complete recording from one LEMS patient demonstrating an initial small resting<br />
compound muscle action potential(CMAP), followed by a 10-second period <strong>of</strong> maximal<br />
voluntary contraction <strong>and</strong> subsequently 30 CMAPs illustrating augmentation <strong>and</strong><br />
exponential decay.<br />
Maddison P et al. Neurology 1998;50:1083-1087<br />
0 Ca Direct +Ca +4AP +Mg +4AP Direct TTX<br />
8
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