Physiology and Pathophysiology of Neuromuscular Transmission
Physiology and Pathophysiology of Neuromuscular Transmission
Physiology and Pathophysiology of Neuromuscular Transmission
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R in<br />
Harris & Ribchester (1979) J Physiol 296, 245-265<br />
Endplate area, fibre diameter <strong>and</strong> MEPP amplitude, frequency are correlated<br />
Quantal size (q) = response to a single vesicular release<br />
(i.e. the amplitude <strong>of</strong> the spontaneous MEPP)<br />
Abnormalities in quantal size indicate a postsynaptic problem<br />
Quantal content (m) = amount <strong>of</strong> transmitter released<br />
(i.e. the number <strong>of</strong> synaptic vesicles producing an EPP)<br />
Abnormalities in quantal content indicate a presynaptic problem<br />
<strong>Neuromuscular</strong> Junction: postsynaptic<br />
http://neuromuscular.wustl.edu/musdist/dag2.htm<br />
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