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Physiology and Pathophysiology of Neuromuscular Transmission

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NMJ size <strong>and</strong> muscle mibre diameter are correlated<br />

Specific quantal content (m/µm 2 ) is constant<br />

A<br />

B<br />

100<br />

80<br />

1<br />

60<br />

40<br />

-2<br />

) mµ<br />

m/a<br />

(µm -2 ) 0.1<br />

%Occupancy<br />

% Occupancy<br />

20<br />

0<br />

sub super<br />

m/a (<br />

0.01<br />

sub-sub sub-super super-super<br />

Costanzo et al.(1999) J Physiol 521:365-74<br />

Species<br />

Quantal content<br />

Frog<br />

Rat<br />

Frog 200<br />

Rat, mouse 50-75<br />

Man 20-30<br />

Man<br />

26

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