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Physiology and Pathophysiology of Neuromuscular Transmission

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MEPP<br />

EPP<br />

Quantal analysis<br />

P x<br />

= e!m m x<br />

x!<br />

MEPPs<br />

EPPs<br />

Stim.<br />

Quantal Size:<br />

Quantal Content:<br />

q = MEPP<br />

m = EPP<br />

q<br />

Problems<br />

- Non-Poisson conditions<br />

- MEPP variance<br />

- Non-linear summation<br />

The ACh null-potential (reversal potential) is about -10 mV<br />

22

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