Physiology and Pathophysiology of Neuromuscular Transmission
Physiology and Pathophysiology of Neuromuscular Transmission
Physiology and Pathophysiology of Neuromuscular Transmission
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Poisson distribution <strong>of</strong> Quantal<br />
Contents <strong>of</strong> EPPs (n=100 trials)<br />
40<br />
m=4<br />
Frequency<br />
30<br />
20<br />
10<br />
0<br />
0 1 2 3 4 5 6 7 8 9 10 11 12<br />
Quantal content<br />
Poisson distribution <strong>of</strong> Quantal<br />
Contents <strong>of</strong> EPPs (n=100 trials)<br />
40<br />
m=5<br />
Frequency<br />
30<br />
20<br />
10<br />
0<br />
0 1 2 3 4 5 6 7 8 9 10 11 12<br />
Quantal content<br />
Methods <strong>of</strong> quantal analysis:<br />
1. Direct method : m=EPP/MEPP (better, EPC/MEPPC)<br />
2. Failures method: P(0)=exp(-m); m=Ln(Tests/Failures)<br />
( for binomial: P(0)=(1-p) n )<br />
3. Variance method: m = 1/(C.V.) 2 i.e. m=EPP 2 /var(EPP)<br />
(for binomial: var(m)=npq)<br />
18
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