Physiology and Pathophysiology of Neuromuscular Transmission

MEPPs (aka ‘minis’) are independent events
that occur with low release probability. This
generates and exponential, Poisson distribution
of intervals between events.
If the mean frequency is m (s -1 ), then the
frequency of a given number of MEPPs, x, in
each one second raster sweep is given by:
P(x) = exp(!m). m x
x!
Mini analysis
Amplitude
y = exp(!(x ! µ) 2 / 2" 2 ) / (" 2# )
Interval
Fatt & Katz, 1952, JPhysiol
MEPP
EPP
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