Physiology and Pathophysiology of Neuromuscular Transmission

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Lambert-Eaton Myasthenic Syndrome EMG EPP Normal LEMS EPPs have low quantal content and show facilitation Myasthenia gravis EMG Intracellular recording - NMJ Summary of electrophysiological changes in Myasthenia Gravis and Myasthenic Syndrome 50 (NI=Normal Individual) 10
C h.0 5 m V C h .0 5 m V 5 .0 0 m s 5 .0 0 m s C h .0 C h .0 5 m V 5 m V 5 .0 0 m s 5 .0 0 m s Anticholinesterases increase EPP amplitude and prolong EPP decay time Control Neostigmine (5 µM) Kosala Dissanayake Physiology and Pathophysiology of Neuromuscular Transmission 1. Botulism and Myasthenias 2. Characteristics of MEPPS and EPPS 3. Quantal analysis 4. Synaptic strength and safety factor Desaki & Uehara, 1981, J Neurocytol 10,101 11
Page 1 and 2: Physiology and Pathophysiology of N
Page 3 and 4: ‘Bassoon’ immunostaining locali
Page 5 and 6: Typically-measured characteristics
Page 7 and 8: Botulinum toxins cleave SNARE prote
Page 9: Myasthenia Gravis Before • Bilate
Page 13 and 14: Physiology and Pathophysiology of N
Page 15 and 16: Binomial model: Let: n=3 p= 0.17 (q
Page 17 and 18: Poisson distribution of Quantal Con
Page 19 and 20: Problems - Non-Poisson conditions -
Page 21 and 22: The Normal (Gaussian) Distribution
Page 23 and 24: V ~ I Desaki & Uehara, 1981, J Neur
Page 25 and 26: NMJ have a high ‘safety factor’
Page 27 and 28: Vm 2.5 mV Vm Ch.2 2.5 mV 1 mV Ch.2
Page 29: Congenital Myasthenic Syndromes Pal

Physiology and Pathophysiology of Neuromuscular Transmission

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