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HP Newsletter - Hospice Pharmacia

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Passionate for the Appropriate Use of Medication 3<br />

<strong>HP</strong>’s Seventh Edition of the Medication Use Guidelines<br />

- Douglas J. Weschules, PharmD, BCPS, VP of Clinical Services<br />

<strong>HP</strong> announces the release of the seventh<br />

edition of the Medication Use Guidelines<br />

(MUGs)! excelleRx has been hard at work<br />

for the past twelve months creating this new<br />

volume, and we cannot wait to place it in<br />

your hands. The workload assumed by the<br />

MUGs committee was the most aggressive in<br />

excelleRx’s history, with over 500 hours spent<br />

in the authorship of guidelines, protocols<br />

and monographs alone. Over 40 different<br />

topics were included in the development<br />

of this seventh edition of the MUGs, 28 of<br />

which were suitable for external review. <strong>HP</strong><br />

sincerely thanks each of the 34 development<br />

clinicians and 11 internal review editors and<br />

staff for rising to this challenge.<br />

The changes associated with the seventh<br />

edition of the MUGs are not limited to just<br />

the review topics themselves, however. The<br />

process associated with MUGs development<br />

also continues to mature every year.<br />

Noteworthy examples of this evolution<br />

this year include the development and use<br />

of guideline templates for Development<br />

Clinicians (authors) to follow, as well as the<br />

grading of evidence associated with these<br />

documents.<br />

So, what will you see in this new edition?<br />

Completely new guidelines include:<br />

• Urinary Incontinence<br />

• Bowel Obstruction<br />

• Failure to Thrive/Debility, Unspecified<br />

New medications and therapy options for<br />

existing guidelines include:<br />

• Roxicodone tablets, 15 and 30 mg<br />

• Valproic acid-based SeizureKit<br />

Additional detail and enhancements have<br />

also been added to the following guidelines:<br />

• Alzheimer’s Disease<br />

• Anxiety<br />

• Agitation<br />

• Congestive Heart Failure<br />

• COPD<br />

• Nociceptive Pain<br />

• Urinary Tract Infections<br />

Many medications were reviewed but not<br />

added to the seventh edition of the MUGs,<br />

either because of a lack of evidence to<br />

support their use in the hospice population<br />

or because MUG alternatives exist that are<br />

comparable and/or more cost effective.<br />

Medications included in the external review<br />

process that were not added to the MUGs are<br />

outlined below by reason:<br />

Not enough evidence to support their<br />

addition to the MUGs:<br />

• Antihypertensives for the palliation of<br />

end stage CVA<br />

• Donepezil (Aricept®)<br />

• Galantamine (Razadyne®)<br />

• Hydromorphone sustained-release<br />

(Palladone®)<br />

• Memantine (Namenda®)<br />

• Nebulized dexamethasone for COPD or<br />

dyspnea<br />

• Nebulized lidocaine for cough<br />

• Pregabalin (Lyrica®)<br />

• Tiagabine (Gabitril®)<br />

• Tiotropium (Spiriva®)<br />

• Valproic acid for the management of<br />

agitation associated with dementia<br />

A comparable MUG medication already exists<br />

and/or is more cost-appropriate:<br />

• Albuterol sulfate/ipratropium bromide<br />

(DuoNeb®)<br />

• Citalopram (Celexa®)<br />

• Clopidogrel (Plavix®)<br />

• Dalteparin (Fragmin®)<br />

• Enoxaparin (Lovenox®)<br />

• Levetiracetam (Keppra®)<br />

• Morphine sulfate sustained-release<br />

capsule (Avinza®)<br />

• Olanzapine (Zyprexa®)<br />

• Torsemide (Demadex®)<br />

• Tramadol (Ultram®)<br />

In addition, the following medications were<br />

reviewed internally, but were not part of the<br />

external review process:<br />

• Acetylcysteine (Mucomyst®)<br />

• Carvedilol (Coreg®)<br />

• Magnesuim oxide (Mag Ox®)<br />

• Oral ketamine (Ketalar®)<br />

• Quinine sulfate<br />

As you can see, the external review process<br />

was robust. Many clinicians from partnering<br />

hospices and programs participated in<br />

this process. The vast majority of external<br />

reviewers agreed that each document they<br />

reviewed provided a thorough analysis of<br />

each topic, a complete literature review, and<br />

agreed with the findings of the author. A few<br />

questions and concerns were highlighted<br />

throughout this process, all of which helped<br />

to influence the MUGs committee’s ultimate<br />

decisions for the seventh edition of the<br />

MUGs. If you are interested in participating<br />

in the external review process in the future,<br />

please let us know!<br />

The Seventh Edition of the MUGs will be<br />

mailed to <strong>Hospice</strong> <strong>Pharmacia</strong> partners in<br />

the next several weeks and will be effective<br />

on November 1st, 2005. Information<br />

regarding the preparatory teleconferences<br />

is available on our website.<br />

If you have any questions regarding the<br />

release of the MUGs, or about any of<br />

its content, please contact the MUGs<br />

committee at MUGs@excellerx.com.<br />

www.hospicepharmacia.com

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