HP Newsletter - Hospice Pharmacia

HP Newsletter - Hospice Pharmacia HP Newsletter - Hospice Pharmacia

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Passionate for the Appropriate Use of Medication Volume 5 | Issue 3 An Omnicare Company “Proven and Safer...” Application of Evidence-based Algorithms Increases Quality Measures and Reduces Medication Costs in Hospice Patients - Calvin H Knowlton, RPh, MDiv, PhD, CEO In This Issue excelleRx Institute Update 2 Medication Use Guidelines 3 excelleRx Supports Care Coordination Solutions Forum for WHCoA 4 Hospice Fund Raisers 4 Dear Laura 5 HP Update 6 Clinical Pharmacology via Xeris 7 Research Update 7 IT Corner 8 The steady stream of reports about medication misadventuring and the burgeoning public health crisis related to patient safety consistently lead us at Hospice Pharmacia to strengthen our resolve toward evidence-based pharmaceutical care, and to act on our insights in “real-time.” For instance, in a recent JAMA article, Drs. Lucian Leape and Donald Berwick, well-known vanguards of patient safety and quality improvement, reported on progress in the five years following the Institute of Medicine (IOM) report on patient safety titled, “To Err is Human.” 1,2 Leape and Berwick noted that, although formidable barriers to progress in systemwide patient safety exist, the health care industry is well positioned to increase the velocity of systemwide improvements. One of the four key strategies they cited is “wide diffusion of proven and safe practices.” Towards that end, Hospice Pharmacia (HP) is immersed in the evolution of three key service components that will generate an even more robust evidence base for the proven and safe practices that Leape and Berwick champion. These innovations include HP’s: 1) Peer-reviewed, evidence-based Medication Use Guidelines (MUGs); 2) Collaborative Practice model for pharmaceutical care management; and 3) Risk stratification engine, “advisoRx,” that allows the immediate identification of patients at greatest risk for medication related problems (MRPs), enabling an expedient resolution through nurse/prescriber communication followed by aggressive monitoring. Most hospice clinicians are familiar with HP’s Medication Use Guidelines, a tool that has grown in scope and sophistication over the past nine years. Many of your hospice colleagues have been involved in the review of the MUGs and are keenly aware of the excelleRx pharmacist/authors’ year long labor of primary literature review. What you may not know is that our research team conducts a variety of studies, drawing on our ever-growing patient database to validate these guidelines. In a recently completed study to evaluate the effectiveness of HP’s Collaborative Practice model and select symptom management protocols, we examined differences in symptom scores between two groups of randomly selected patients: a) those who received selected first line MUG therapies for pain, insomnia, or nausea and b) those who received medications prescribed outside of Collaborative Practice and the MUGs to treat the same symptoms (N=50/group for each symptom protocol comparison). Outcomes were patients’ self-reported measures of symptom intensity using a 0-10 numeric analog scale. Highlights from this study include: • Pain: 28% of patients receiving either sustainedrelease morphine or oxycodone achieved a complete response, as compared with 24% of patients prescribed fentanyl. - This finding suggests that transdermal opioids are no more effective in treating pain than less expensive sustained-release oral agents, which supports HP’s position that transdermal fentanyl should be reserved for those patients who require transdermal administration of an opioid medication due to dysphagia, GI absorption problems, etc. continued on page 8 www.hospicepharmacia.com

Passionate for the Appropriate Use of Medication<br />

Volume 5 | Issue 3<br />

An Omnicare Company<br />

“Proven and Safer...”<br />

Application of Evidence-based Algorithms Increases Quality Measures and<br />

Reduces Medication Costs in <strong>Hospice</strong> Patients<br />

- Calvin H Knowlton, RPh, MDiv, PhD, CEO<br />

In This Issue<br />

excelleRx Institute Update<br />

2<br />

Medication Use Guidelines<br />

3<br />

excelleRx Supports Care<br />

Coordination Solutions<br />

Forum for WHCoA<br />

4<br />

<strong>Hospice</strong> Fund Raisers<br />

4<br />

Dear Laura<br />

5<br />

<strong>HP</strong> Update<br />

6<br />

Clinical Pharmacology via<br />

Xeris<br />

7<br />

Research Update<br />

7<br />

IT Corner<br />

8<br />

The steady stream of reports about medication<br />

misadventuring and the burgeoning public health<br />

crisis related to patient safety consistently lead us at<br />

<strong>Hospice</strong> <strong>Pharmacia</strong> to strengthen our resolve toward<br />

evidence-based pharmaceutical care, and to act on our<br />

insights in “real-time.”<br />

For instance, in a recent JAMA article, Drs. Lucian<br />

Leape and Donald Berwick, well-known vanguards<br />

of patient safety and quality improvement, reported<br />

on progress in the five years following the Institute of<br />

Medicine (IOM) report on patient safety titled, “To<br />

Err is Human.” 1,2 Leape and Berwick noted that,<br />

although formidable barriers to progress in systemwide<br />

patient safety exist, the health care industry is<br />

well positioned to increase the velocity of systemwide<br />

improvements. One of the four key strategies<br />

they cited is “wide diffusion of proven and safe<br />

practices.” Towards that end, <strong>Hospice</strong> <strong>Pharmacia</strong><br />

(<strong>HP</strong>) is immersed in the evolution of three key service<br />

components that will generate an even more robust<br />

evidence base for the proven and safe practices that<br />

Leape and Berwick champion. These innovations<br />

include <strong>HP</strong>’s:<br />

1) Peer-reviewed, evidence-based Medication Use<br />

Guidelines (MUGs);<br />

2) Collaborative Practice model for pharmaceutical<br />

care management; and<br />

3) Risk stratification engine, “advisoRx,” that<br />

allows the immediate identification of patients<br />

at greatest risk for medication related problems<br />

(MRPs), enabling an expedient resolution<br />

through nurse/prescriber communication<br />

followed by aggressive monitoring.<br />

Most hospice clinicians are familiar with <strong>HP</strong>’s<br />

Medication Use Guidelines, a tool that has grown in<br />

scope and sophistication over the past nine years.<br />

Many of your hospice colleagues have been involved<br />

in the review of the MUGs and are keenly aware of<br />

the excelleRx pharmacist/authors’ year long labor of<br />

primary literature review. What you may not know is<br />

that our research team conducts a variety of studies,<br />

drawing on our ever-growing patient database to<br />

validate these guidelines.<br />

In a recently completed study to evaluate the<br />

effectiveness of <strong>HP</strong>’s Collaborative Practice model and<br />

select symptom management protocols, we examined<br />

differences in symptom scores between two groups<br />

of randomly selected patients: a) those who received<br />

selected first line MUG therapies for pain, insomnia,<br />

or nausea and b) those who received medications<br />

prescribed outside of Collaborative Practice and the<br />

MUGs to treat the same symptoms (N=50/group for<br />

each symptom protocol comparison). Outcomes were<br />

patients’ self-reported measures of symptom intensity<br />

using a 0-10 numeric analog scale. Highlights from<br />

this study include:<br />

• Pain: 28% of patients receiving either sustainedrelease<br />

morphine or oxycodone achieved a<br />

complete response, as compared with 24% of<br />

patients prescribed fentanyl.<br />

- This finding suggests that transdermal opioids<br />

are no more effective in treating pain than<br />

less expensive sustained-release oral agents,<br />

which supports <strong>HP</strong>’s position that transdermal<br />

fentanyl should be reserved for those patients<br />

who require transdermal administration of<br />

an opioid medication due to dysphagia, GI<br />

absorption problems, etc.<br />

continued on page 8<br />

www.hospicepharmacia.com


2<br />

Passionate for the Appropriate Use of Medication<br />

Education Corner<br />

- Jillian N. Prusakowski, PharmD, Education Manager<br />

The excelleRx Institute is committed to<br />

collaborating with hospices to enhance<br />

pharmacotherapy outcomes for patients<br />

through education, research and participation<br />

in public policy. As a benefit to hospices, we<br />

provide palliative care educational programs to<br />

enhance practice and career growth for health<br />

care professionals.<br />

“Introduction to Non-opioid and Opioid Pain<br />

Therapy” was offered as a web teleconference<br />

in February. There were 173 hospices<br />

registered for this program. Over 440 health<br />

care professionals received credit for this<br />

continuing education session. This program is<br />

now available online as an independent study.<br />

“Beyond Opioids: Adjuvant Drug Therapy”<br />

was conduced in May. There were 116<br />

hospices registered and over 312 health care<br />

professionals received continuing education<br />

credit for the program!<br />

Most recently in August, we presented<br />

“Pharmacotherapy for the Anxious and<br />

Agitated Patient.” Approximately 200<br />

hospices registered and roughly 900 health<br />

care professionals requested to participate!<br />

Other CNE modules available online are listed<br />

below. Please visit the recently updated CNE<br />

website www.hospicepharmacia.com. The<br />

programs available include:<br />

Palliative Sedation in <strong>Hospice</strong> Patients<br />

Palliative Care in Amyotrophic Lateral<br />

Sclerosis<br />

Palliative Care in Patients with<br />

Dementia<br />

Palliative Care in Huntington’s<br />

Disease<br />

Palliative Treatment of Dyspnea<br />

Management of Seizures in<br />

End of Life Care<br />

The Palliative Management of<br />

Insomnia<br />

Introduction to Non-opioid and<br />

Opioid Pain Therapy<br />

Beyond Opioids: Adjuvant<br />

Drug Therapy<br />

Pharmacotherapy for the Anxious<br />

and Agitated Patient<br />

“Management of Common Gastrointestinal<br />

Complaints at the End of Life,”<br />

will be held on:<br />

• November 8, 2005 at 9:00am EST<br />

• November 9, 2005 at 12:00pm EST<br />

• November 10, 2005 at 3pm EST<br />

Laura Scarpaci, PharmD is the speaker.<br />

She is the Palliative Care Pharmacy Practice<br />

Resident at the University of Maryland,<br />

School of Pharmacy.<br />

This CE program is designed to equip nurses<br />

with the tools needed to manage common<br />

gastrointestinal symptoms encountered at<br />

the end of life such as nausea, vomiting and<br />

diarrhea.<br />

An overview of recent advances will<br />

be provided in addition to a review<br />

of pharmacological agents and nonpharmacological<br />

techniques typically used<br />

in the management of these troubling<br />

symptoms. The presentation will also<br />

incorporate several cases to demonstrate<br />

how the material can be applied to real-life<br />

situations.<br />

After participation in the program, the<br />

audience will be able to:<br />

1. Identify common etiologies associated<br />

with nausea, vomiting, and diarrhea at<br />

the end of life.<br />

2. Differentiate between the available<br />

pharmacological agents for the<br />

treatment of common end-of-life<br />

gastrointestinal symptoms with regards<br />

to their mechanism of action, side<br />

effects, and indications.<br />

3. Create an appropriate drug regimen<br />

based on patient-specific factors and<br />

clinical appropriateness for managing<br />

common end-of-life gastrointestinal<br />

symptoms.<br />

If you would like to learn more about the<br />

excelleRx Institute educational programs,<br />

please contact Dr. Jill Pfeiffenberger,<br />

Director of Education for the excelleRx<br />

Institute, by calling 877.882.7822, ext<br />

1677 or by emailing jillp@excellerx.com.<br />

Register now for<br />

education regarding<br />

<strong>HP</strong>’s Seventh Edition<br />

of the Medication Use<br />

Guidelines!<br />

www.hospicepharmacia.com


Passionate for the Appropriate Use of Medication 3<br />

<strong>HP</strong>’s Seventh Edition of the Medication Use Guidelines<br />

- Douglas J. Weschules, PharmD, BCPS, VP of Clinical Services<br />

<strong>HP</strong> announces the release of the seventh<br />

edition of the Medication Use Guidelines<br />

(MUGs)! excelleRx has been hard at work<br />

for the past twelve months creating this new<br />

volume, and we cannot wait to place it in<br />

your hands. The workload assumed by the<br />

MUGs committee was the most aggressive in<br />

excelleRx’s history, with over 500 hours spent<br />

in the authorship of guidelines, protocols<br />

and monographs alone. Over 40 different<br />

topics were included in the development<br />

of this seventh edition of the MUGs, 28 of<br />

which were suitable for external review. <strong>HP</strong><br />

sincerely thanks each of the 34 development<br />

clinicians and 11 internal review editors and<br />

staff for rising to this challenge.<br />

The changes associated with the seventh<br />

edition of the MUGs are not limited to just<br />

the review topics themselves, however. The<br />

process associated with MUGs development<br />

also continues to mature every year.<br />

Noteworthy examples of this evolution<br />

this year include the development and use<br />

of guideline templates for Development<br />

Clinicians (authors) to follow, as well as the<br />

grading of evidence associated with these<br />

documents.<br />

So, what will you see in this new edition?<br />

Completely new guidelines include:<br />

• Urinary Incontinence<br />

• Bowel Obstruction<br />

• Failure to Thrive/Debility, Unspecified<br />

New medications and therapy options for<br />

existing guidelines include:<br />

• Roxicodone tablets, 15 and 30 mg<br />

• Valproic acid-based SeizureKit<br />

Additional detail and enhancements have<br />

also been added to the following guidelines:<br />

• Alzheimer’s Disease<br />

• Anxiety<br />

• Agitation<br />

• Congestive Heart Failure<br />

• COPD<br />

• Nociceptive Pain<br />

• Urinary Tract Infections<br />

Many medications were reviewed but not<br />

added to the seventh edition of the MUGs,<br />

either because of a lack of evidence to<br />

support their use in the hospice population<br />

or because MUG alternatives exist that are<br />

comparable and/or more cost effective.<br />

Medications included in the external review<br />

process that were not added to the MUGs are<br />

outlined below by reason:<br />

Not enough evidence to support their<br />

addition to the MUGs:<br />

• Antihypertensives for the palliation of<br />

end stage CVA<br />

• Donepezil (Aricept®)<br />

• Galantamine (Razadyne®)<br />

• Hydromorphone sustained-release<br />

(Palladone®)<br />

• Memantine (Namenda®)<br />

• Nebulized dexamethasone for COPD or<br />

dyspnea<br />

• Nebulized lidocaine for cough<br />

• Pregabalin (Lyrica®)<br />

• Tiagabine (Gabitril®)<br />

• Tiotropium (Spiriva®)<br />

• Valproic acid for the management of<br />

agitation associated with dementia<br />

A comparable MUG medication already exists<br />

and/or is more cost-appropriate:<br />

• Albuterol sulfate/ipratropium bromide<br />

(DuoNeb®)<br />

• Citalopram (Celexa®)<br />

• Clopidogrel (Plavix®)<br />

• Dalteparin (Fragmin®)<br />

• Enoxaparin (Lovenox®)<br />

• Levetiracetam (Keppra®)<br />

• Morphine sulfate sustained-release<br />

capsule (Avinza®)<br />

• Olanzapine (Zyprexa®)<br />

• Torsemide (Demadex®)<br />

• Tramadol (Ultram®)<br />

In addition, the following medications were<br />

reviewed internally, but were not part of the<br />

external review process:<br />

• Acetylcysteine (Mucomyst®)<br />

• Carvedilol (Coreg®)<br />

• Magnesuim oxide (Mag Ox®)<br />

• Oral ketamine (Ketalar®)<br />

• Quinine sulfate<br />

As you can see, the external review process<br />

was robust. Many clinicians from partnering<br />

hospices and programs participated in<br />

this process. The vast majority of external<br />

reviewers agreed that each document they<br />

reviewed provided a thorough analysis of<br />

each topic, a complete literature review, and<br />

agreed with the findings of the author. A few<br />

questions and concerns were highlighted<br />

throughout this process, all of which helped<br />

to influence the MUGs committee’s ultimate<br />

decisions for the seventh edition of the<br />

MUGs. If you are interested in participating<br />

in the external review process in the future,<br />

please let us know!<br />

The Seventh Edition of the MUGs will be<br />

mailed to <strong>Hospice</strong> <strong>Pharmacia</strong> partners in<br />

the next several weeks and will be effective<br />

on November 1st, 2005. Information<br />

regarding the preparatory teleconferences<br />

is available on our website.<br />

If you have any questions regarding the<br />

release of the MUGs, or about any of<br />

its content, please contact the MUGs<br />

committee at MUGs@excellerx.com.<br />

www.hospicepharmacia.com


4<br />

Passionate for the Appropriate Use of Medication<br />

excelleRx Supports Care Coordination Solutions Forum for WHCoA<br />

- Diane Jones, MSW, Director of excelleRx Institute<br />

excelleRx joined several national fundraising<br />

organizations in supporting a critical White<br />

House Conference on Aging (WHCoA)<br />

Solutions Forum, Care Coordination<br />

Across the Continuum. The event focused<br />

on articulating cutting edge solutions<br />

rather than repeating the many well-known<br />

problems associated with our current<br />

healthcare system. Held at the Russell Senate<br />

Office Building on July 19, 2005, an expert<br />

panel of 15 luminaries spoke to an audience<br />

comprised of policy makers, non-government<br />

organizations, healthcare industry leaders<br />

and the press.<br />

The Care Coordination Across the Continuum<br />

Solutions Forum was among hundreds of<br />

grass roots events that have been held across<br />

the country over the past year and a half for the<br />

purpose of making recommendations to the<br />

WHCoA Policy Committee for consideration.<br />

The recommendations presented by the<br />

Care Coordination event specifically deal<br />

with healthcare in the final years of life and<br />

envision a healthcare system with seamless<br />

coordination of comprehensive, reliable, and<br />

readily accessible medical care and supportive<br />

services over time and across settings.<br />

Adherence to evidence-based standards and<br />

guidelines for treatments, medication therapy<br />

management, and services, was one of several<br />

critical elements of optimal coordinated care<br />

advanced by the Solutions Forum.<br />

The full report from the Care Coordination<br />

Across the Continuum Solutions Forum can<br />

be downloaded at www.medicaring.org/<br />

whcoa. For information about other activities<br />

of the White House Conference on Aging go<br />

to www.whcoa.gov. If implemented, these<br />

recommendations could have sweeping<br />

impact on the delivery of health care for the<br />

next decade.<br />

JoAnne Reifsnyder, PhD, SVP of Research<br />

and Innovation at excelleRx and Diane Jones,<br />

MSW, Director of the excelleRx Institute<br />

were members of the planning committee.<br />

Jones also coordinated the event.<br />

The White House Conference on Aging<br />

occurs once a decade to make aging policy<br />

recommendations to the President and<br />

Congress, and to assist the public and<br />

private sectors in promoting dignity, health,<br />

independence and economic security of<br />

current and future generations of older<br />

persons. The upcoming White House<br />

Conference on Aging will be the first one<br />

of the 21st century and is scheduled to<br />

take place December 11 – 14, 2005 in<br />

Washington, DC.<br />

Here are two specific steps you can take to<br />

get your voice heard:<br />

• Call the offices of your Congressperson<br />

and Senator, and be sure that their<br />

health staffers are on board. You can<br />

use the online Congressional Directory<br />

to find contact information.<br />

• Use the WHCoA online contact<br />

form and tell them how important it<br />

is that they pay attention to serious<br />

chronic illness, continuity, and<br />

caregiving - and that they follow at<br />

least the recommendations of the Care<br />

Coordination Across the Continuum<br />

Solutions Forum.<br />

HOSPICE FUND-RAISERS...<br />

Attention non-for-profi t hospices and for for-profi t hospice<br />

foundations that are looking for a turn-key fund-raising event: “A<br />

Good Idea” fund-raiser event, featuring singer-song writer Karen-<br />

Taylor Good, may work for you!<br />

If you are unfamiliar with Ms. Good’s talents and abilities either, visit<br />

www.hospicepharmacia.com and click on “<strong>Hospice</strong> Fund-Raiser” or,<br />

attend our annual <strong>Hospice</strong> Appreciation Dinner on Friday September<br />

23rd, where Karen will highlight components of her fundraising ideas.<br />

If you would like to share a good idea for a hospice fund-raiser, send<br />

your idea to <strong>HP</strong>Partners@excelleRx.com!<br />

www.hospicepharmacia.com


Passionate for the Appropriate Use of Medication 5<br />

Dear Laura,<br />

I use <strong>HP</strong>’s Xeris on-line tools often and recently noticed two new<br />

icons on the toolbar. Can you explain what these are for?<br />

Lori<br />

Lori,<br />

I’m glad to hear that you are enjoying the benefits of Xeris<br />

enough to realize its multitude of functions! The first new icon<br />

(the second one up from the bottom on the toolbar) links you<br />

to Gold Standard Multimedia’s Clinical Pharmacology clinical<br />

information database. This on-line database provides extensive<br />

drug information, such as general drug descriptions, product<br />

identification, and patient education. Please refer to the related<br />

article in this newsletter.<br />

The second new icon, which is the very last one on the toolbar, is<br />

our Xeris Help link. This link will provide a demonstration on how<br />

to perform different functions in Xeris. Currently, a demonstration<br />

of the admissions process is posted. We will be adding<br />

demonstrations on profiling medications, discharging patients,<br />

refilling medications, Xeris <strong>Hospice</strong> Administrator functions, and<br />

more! Stay Tuned!<br />

Thanks!<br />

Dear Laura,<br />

I was trying to refill a medication through your Automated<br />

Refill and Discharge System (ARDS) and it prompted me<br />

to enter my PIN after I keyed in my patient’s social security<br />

number. I don’t have a PIN and can’t remember my<br />

password for Xeris. What should I do?<br />

Gwen<br />

Gwen,<br />

The Xeris <strong>Hospice</strong> Administrator (XHA) at your hospice<br />

has enabled your Xeris account for PIN since the system<br />

is prompting you for one. That was the correct thing to<br />

do since you are a nurse and will be using the Medication<br />

Management Support Center (MMSC) and its services.<br />

Please see your XHA so that he or she can reset your<br />

password. You can then use this new temporary password<br />

to login to Xeris and create a PIN. You will need your PIN<br />

any time you call <strong>HP</strong> or use the telephone automation for<br />

one of your patients on service. Please let your XHA know<br />

if you have any questions on the process.<br />

Thanks!<br />

Laura<br />

Laura<br />

Laura Lutz is the Client Development Manager at <strong>Hospice</strong> <strong>Pharmacia</strong>. She is responsible for coordinating implementations<br />

and for supporting new hospice partners as they transition from their current pharmacy providers to <strong>HP</strong>. Laura also helps<br />

with the planning and organization of <strong>HP</strong>’s educational programs, including monthly Xeris training and orientation webteleconferences.<br />

Laura can be reached by emailing <strong>HP</strong>Partners@excelleRx.com.<br />

<strong>Hospice</strong> <strong>Pharmacia</strong> is a service of excelleRx, Inc., an Omnicare Company.<br />

© Copyright 2005 Xeris, Predictive Pharmacotherapy Outcomes System (PPOS), Prospective Medication Management, Medication Use Guidelines (MUGs), ComfortPak, SeizureKit,<br />

<strong>Hospice</strong> <strong>Pharmacia</strong> Collaborative Practice (<strong>HP</strong>CP), and all Xeris products and their respective logos are Trademarks of excelleRx, Inc. All rights reserved. No part of the information<br />

contained herein may be reproduced, duplicated, or copied without permission. Please inquire if you are not sure. PPOS and Xeris are Patent Pending.<br />

www.hospicepharmacia.com


6<br />

Passionate for the Appropriate Use of Medication<br />

<strong>HP</strong> Continues to Enhance Quality While Adding Opportunities for Savings<br />

Streamlined Performance Incentive Program, Added Discount on AWP for Medications Outside<br />

of Protocol, and the Lowest Annual Price Adjustment Ever<br />

- Calvin H. Knowlton, RPh, MDiv., PhD, CEO<br />

<strong>Hospice</strong> <strong>Pharmacia</strong> is very pleased to<br />

announce an enhanced and simplified<br />

Performance Incentive Program (PIP),<br />

effective October 1, 2005, simultaneous<br />

with the launch of the new edition (VII) of<br />

the Medication Use Guidelines. There are<br />

two components to this new PIP, which will<br />

be assessed each month and automatically<br />

applied to your monthly statement.<br />

1. Earn a 0.50% discount for having 85%<br />

of your home care patients assessed for<br />

ComfortPaks.<br />

2. Earn a 0.75% discount for having<br />

a functional interface between your<br />

software and <strong>HP</strong>’s Xeris software. A<br />

functional interface means either an FTP<br />

or HL7 interface whereby >75% of your<br />

referrals/admissions are communicated<br />

successfully via the electronic interface.<br />

We have removed the PIN, outcomes<br />

reporting, and automated refills performance<br />

benchmarks as we have found the reporting<br />

functionality, especially reporting by nurse,<br />

is already a great incentive for hospices to<br />

encourage their staff to use their PIN. The<br />

automated refill system will become much<br />

easier with the introduction of voice to text<br />

technology (targeted for 4q05) where the<br />

nurse may say the patient’s phone number,<br />

the PIN, and the refill number, instead of<br />

having to use the telephone key pad.<br />

Additionally, with the recent merger, wherein<br />

excelleRx became a division of Omnicare, we are<br />

able to take advantage of enhanced purchasing<br />

power on medications that were traditionally<br />

low volume for our organization—basically<br />

the non-MUG medications. Therefore, also<br />

effective October 1, 2005, we will be reducing<br />

the medication price on our non-MUG<br />

medications. Certainly, this is not to encourage<br />

the use of non-MUGs!<br />

<strong>HP</strong>’s per diems are set based upon a hospice’s<br />

percentage of patients with cancer (vs. noncancer)<br />

diagnoses. We have very specific and<br />

detailed information correlating increased<br />

<strong>HP</strong> encounters and medication mix with<br />

higher cancer rates. While we monitor this<br />

information on a quarterly basis, this year has<br />

been significant in that dozens of our hospices<br />

have received a per diem reduction letter from<br />

<strong>HP</strong> because their cancer rate has dropped to<br />

a lower bracket for two consecutive quarters<br />

(e.g., from 45% to 35%).<br />

Finally, every October is when most of our<br />

hospice clients receive an annual per diem<br />

price adjustment. This October will be the<br />

lowest price adjustment in <strong>HP</strong>’s nine year<br />

history—less than half of the 4.4% Producer<br />

Price Index for Opioids (which is what<br />

we use as our upper threshold each year).<br />

Specifically, the <strong>HP</strong> per diem will increase<br />

less than 2%, effective October 1, 2005.<br />

Because AWP (Average Wholesale Price) is<br />

adjusted by pharmaceutical manufacturers,<br />

hospices are left without any controls on drug<br />

pricing in the fee-for-service environment.<br />

<strong>HP</strong>’s documented ability to help hospices<br />

control costs is exemplary considering the<br />

continued double-digit pharmacy increases<br />

experienced in the healthcare industry<br />

today.<br />

So, in addition to our system for Prospective<br />

Medication Therapy Management, our new<br />

economies of scale are helping to hold down<br />

your total pharmacy costs!<br />

“I appreciate all that hospice pharmacia does for us.<br />

I have been involved in hospice care for six years and<br />

I think that <strong>Hospice</strong> <strong>Pharmacia</strong> does a wonderful<br />

job helping the nursing staff to understand what can<br />

sometimes make us feel so lost. Many thanks.”<br />

Partnering <strong>Hospice</strong> Nurse<br />

August, 2005<br />

www.hospicepharmacia.com


Passionate for the Appropriate Use of Medication 7<br />

Research Update<br />

- Terri Maxwell, RN, PhD(c)<br />

Clinical Pharmacology<br />

via Xeris<br />

As you may have read in our last newsletter,<br />

<strong>HP</strong> has entered into a partnership with Gold<br />

Standard Multi-Media. The outcome of this<br />

partnership is that Clinical Pharmacology is<br />

now available through a special subscription<br />

to Xeris users! <strong>Hospice</strong> <strong>Pharmacia</strong> partners<br />

can enjoy a 90-day free trial, that began<br />

August 1, 2005.<br />

With several studies underway, and several in the pipeline, there is a lot happening in the<br />

Research Department. Current study topics include:<br />

• Examining patient response to long-acting opioids measured on a 0-10 pain rating scale;<br />

• Testing and evaluating our “Patient Reported Outcomes Measures” (PROM) system<br />

that uses innovative IVR technology;<br />

• Evaluating the effects of prospective medication therapy management on patient<br />

hospitalizations and after-hours nursing visits in hospice;<br />

• Evaluating factors that predispose hospice patients to experiencing a fall; and<br />

• Describing groups of hospice patients: pediatric patients, patients with heart failure,<br />

and patients with dementia.<br />

We look forward to sharing the findings from these studies in upcoming newsletters.<br />

After the trial period, hospice partners may<br />

continue their access through a discount<br />

program that translates to a savings of up to<br />

75% for any hospice with greater than four<br />

users!<br />

Clinical Pharmacology provides the most<br />

up to date and accurate drug information<br />

available, and features:<br />

• Medication Monographs<br />

• Therapeutic Class Overviews<br />

• Search Capabilities (for medications by<br />

brand/generic, indication, therapeutic<br />

classification, contraindication, adverse<br />

reaction)<br />

• Drug Interaction Reports<br />

• Adverse Reaction Reports<br />

• Product Identification<br />

• Patient Education<br />

Founded in 1993, Gold Standard is a leading<br />

developer of drug information databases,<br />

software, and clinical information solutions.<br />

<strong>HP</strong> is pleased to be able to provide you with<br />

even more resources to facilitate the best<br />

possible patient care.<br />

For more information on this special offering,<br />

email <strong>HP</strong>Partners@excelleRx.com.<br />

Calling All <strong>Hospice</strong> Medical Directors and<br />

Clinical Research Staff:<br />

JOIN US FOR A RESEARCH TELECONFERENCE!<br />

Title: Building the Evidence Base for <strong>Hospice</strong> Symptom<br />

Management: A Research Teleconference for<br />

<strong>Hospice</strong> Medical Directors and Clinicians<br />

Date: Monday, October 24, 2005<br />

Time: 12 pm-1 pm EDT<br />

Objectives:<br />

• Identify gaps in the evidence base for common<br />

symptoms experienced at the end of life.<br />

• Discuss challenges associated with documentation of<br />

outcomes in hospice.<br />

• Describe findings from recent investigations related<br />

to symptom control, epidemiology, and medication<br />

selection in hospice.<br />

Facilitator: Richard Stefanacci DO, MGH, MBA, AGSF,<br />

CMD, Executive Director, University of the Sciences in<br />

Philadelphia Health Policy Institute<br />

www.hospicepharmacia.com


8<br />

Passionate for the Appropriate Use of Medication<br />

“Proven and Safer...”<br />

continued from page 1<br />

“I forgot my PIN!”<br />

- Mark Schreiber, Technical Support<br />

Manager<br />

We are delighted that more than 80%<br />

of our hospice clients are participating<br />

in the PIN (Personal Identification<br />

Number) program. The purpose of the<br />

PIN program is to comply with HIPAA’s<br />

Privacy Rule.<br />

Just a reminder: Even if a hospice team<br />

member does not use Xeris, he or she<br />

still needs a Xeris account in order to<br />

obtain a PIN number, as we establish<br />

and keep record of nurse profiles in<br />

Xeris. Every <strong>HP</strong> hospice has selected<br />

a Xeris <strong>Hospice</strong> Administrator (XHA)<br />

who serves as the Xeris security liaison<br />

between the hospice and <strong>HP</strong>. The XHA<br />

is authorized to create Xeris accounts<br />

and reset Xeris passwords. Since PIN<br />

is managed through Xeris, your XHA is<br />

authorized to reset your PIN, should you<br />

forget it what it is.<br />

You may also consult the Xeris Reference<br />

Manual with questions. An updated<br />

version of this manual may be found<br />

on the Xeris Welcome Page in the “<strong>HP</strong><br />

Announcements” section.<br />

Your Regional Director of Client<br />

Development (RDCD) is available to<br />

assist with any of the above steps. If you<br />

have any further questions regarding<br />

PIN, please contact your RDCD, or email<br />

<strong>HP</strong>Partners@excelleRx.com. If you are<br />

an XHA and require technical assistance,<br />

feel free to contact our Technical Support<br />

team at support@excellerx.com.<br />

• Insomnia: A statistically significant<br />

number of patients receiving temazepam<br />

(a first line therapy for insomnia in the<br />

MUGs) achieved a complete response as<br />

compared with zolpidem (52% vs. 22%,<br />

p < 0.05).<br />

- This finding suggests that <strong>HP</strong>’s first<br />

line therapy of temazepam is more<br />

effective in treating insomnia than<br />

zolpidem, a common medication<br />

that is used outside of the insomnia<br />

protocol.<br />

• Nausea: A statistically significant<br />

proportion of patients receiving<br />

prochlorperazine (<strong>HP</strong>’s first line therapy<br />

for nausea) achieved a complete response<br />

as compared to patients taking oral<br />

ondansetron, an expensive alternative<br />

commonly prescribed in the oncology<br />

community (48.9% vs. 26.7%; p < 0.05).<br />

The study also found a striking difference<br />

between patient groups that experienced<br />

worsened nausea control after initiating<br />

therapy (8.9% for prochlorperazine vs.<br />

26.7% for ondansetron, p < 0.05).<br />

- This finding suggests that<br />

ondansetron is not superior to<br />

prochlorperazine, in treating<br />

nausea that is secondary to an<br />

unknown etiology (e.g. not receiving<br />

chemotherapy or radiation).<br />

We launched the aforementioned study<br />

to test the hypothesis that <strong>HP</strong>’s evidencebased<br />

Medication Use Guidelines are<br />

associated with better hospice and patientrelated<br />

outcomes. Our findings suggest<br />

that evidence-based prescribing using the<br />

MUGs produces better patient outcomes<br />

when compared to “preference-based”<br />

prescribing.<br />

In addition, while this study was not<br />

constructed to analyze the cost-effectiveness<br />

of the symptom management medications<br />

selected for analysis, it is noteworthy that<br />

<strong>HP</strong>’s first-line therapies in this study are<br />

less costly than the non-MUG medications<br />

to which they were compared.<br />

These findings support the application of<br />

the MUGs as evidence-based guidelines<br />

that both improve symptom management<br />

and assure cost-appropriate medication<br />

selection for hospice patients, especially<br />

when applied under the prescriberdirected,<br />

pharmacist-driven Collaborative<br />

Practice model.<br />

The bottom line: When the right medication<br />

is selected the first time and the patient is<br />

monitored for therapeutic and potential or<br />

actual adverse effects, patients are not just<br />

more comfortable, they experience greater<br />

safety from untoward adverse medication<br />

outcomes. “Proven and safer”—goals that<br />

should concern every one of us—are within<br />

reach and available to our health care<br />

system’s frailest patients including those<br />

who are receiving hospice care as they<br />

approach the end of life.<br />

1<br />

Leape, L.L. , and Berwick, D.M. (2005). Five years<br />

after To Err is Human: What have we learned? JAMA,<br />

293 (19), 2384-2390.<br />

2<br />

Kohn, K.T., Corrigan, J.M., & Donaldson, M.<br />

(1999). To err is human: Building a safer health care<br />

system. Washington, DC: National Academy Press.<br />

excelleRx <strong>Newsletter</strong> Staff<br />

Editor In Chief:<br />

Orsula Voltis, PharmD, MBA<br />

Chief Marketing Officer<br />

orsula@excelleRx.com<br />

Managing Editor:<br />

Dana Filippoli<br />

Senior Director of Marketing<br />

dfilippoli@excelleRx.com<br />

Layout and Design:<br />

Melissa Morris<br />

Graphic Designer<br />

www.hospicepharmacia.com

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