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HP Newsletter - Hospice Pharmacia

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Passionate for the Appropriate Use of Medication<br />

Volume 5 | Issue 3<br />

An Omnicare Company<br />

“Proven and Safer...”<br />

Application of Evidence-based Algorithms Increases Quality Measures and<br />

Reduces Medication Costs in <strong>Hospice</strong> Patients<br />

- Calvin H Knowlton, RPh, MDiv, PhD, CEO<br />

In This Issue<br />

excelleRx Institute Update<br />

2<br />

Medication Use Guidelines<br />

3<br />

excelleRx Supports Care<br />

Coordination Solutions<br />

Forum for WHCoA<br />

4<br />

<strong>Hospice</strong> Fund Raisers<br />

4<br />

Dear Laura<br />

5<br />

<strong>HP</strong> Update<br />

6<br />

Clinical Pharmacology via<br />

Xeris<br />

7<br />

Research Update<br />

7<br />

IT Corner<br />

8<br />

The steady stream of reports about medication<br />

misadventuring and the burgeoning public health<br />

crisis related to patient safety consistently lead us at<br />

<strong>Hospice</strong> <strong>Pharmacia</strong> to strengthen our resolve toward<br />

evidence-based pharmaceutical care, and to act on our<br />

insights in “real-time.”<br />

For instance, in a recent JAMA article, Drs. Lucian<br />

Leape and Donald Berwick, well-known vanguards<br />

of patient safety and quality improvement, reported<br />

on progress in the five years following the Institute of<br />

Medicine (IOM) report on patient safety titled, “To<br />

Err is Human.” 1,2 Leape and Berwick noted that,<br />

although formidable barriers to progress in systemwide<br />

patient safety exist, the health care industry is<br />

well positioned to increase the velocity of systemwide<br />

improvements. One of the four key strategies<br />

they cited is “wide diffusion of proven and safe<br />

practices.” Towards that end, <strong>Hospice</strong> <strong>Pharmacia</strong><br />

(<strong>HP</strong>) is immersed in the evolution of three key service<br />

components that will generate an even more robust<br />

evidence base for the proven and safe practices that<br />

Leape and Berwick champion. These innovations<br />

include <strong>HP</strong>’s:<br />

1) Peer-reviewed, evidence-based Medication Use<br />

Guidelines (MUGs);<br />

2) Collaborative Practice model for pharmaceutical<br />

care management; and<br />

3) Risk stratification engine, “advisoRx,” that<br />

allows the immediate identification of patients<br />

at greatest risk for medication related problems<br />

(MRPs), enabling an expedient resolution<br />

through nurse/prescriber communication<br />

followed by aggressive monitoring.<br />

Most hospice clinicians are familiar with <strong>HP</strong>’s<br />

Medication Use Guidelines, a tool that has grown in<br />

scope and sophistication over the past nine years.<br />

Many of your hospice colleagues have been involved<br />

in the review of the MUGs and are keenly aware of<br />

the excelleRx pharmacist/authors’ year long labor of<br />

primary literature review. What you may not know is<br />

that our research team conducts a variety of studies,<br />

drawing on our ever-growing patient database to<br />

validate these guidelines.<br />

In a recently completed study to evaluate the<br />

effectiveness of <strong>HP</strong>’s Collaborative Practice model and<br />

select symptom management protocols, we examined<br />

differences in symptom scores between two groups<br />

of randomly selected patients: a) those who received<br />

selected first line MUG therapies for pain, insomnia,<br />

or nausea and b) those who received medications<br />

prescribed outside of Collaborative Practice and the<br />

MUGs to treat the same symptoms (N=50/group for<br />

each symptom protocol comparison). Outcomes were<br />

patients’ self-reported measures of symptom intensity<br />

using a 0-10 numeric analog scale. Highlights from<br />

this study include:<br />

• Pain: 28% of patients receiving either sustainedrelease<br />

morphine or oxycodone achieved a<br />

complete response, as compared with 24% of<br />

patients prescribed fentanyl.<br />

- This finding suggests that transdermal opioids<br />

are no more effective in treating pain than<br />

less expensive sustained-release oral agents,<br />

which supports <strong>HP</strong>’s position that transdermal<br />

fentanyl should be reserved for those patients<br />

who require transdermal administration of<br />

an opioid medication due to dysphagia, GI<br />

absorption problems, etc.<br />

continued on page 8<br />

www.hospicepharmacia.com


2<br />

Passionate for the Appropriate Use of Medication<br />

Education Corner<br />

- Jillian N. Prusakowski, PharmD, Education Manager<br />

The excelleRx Institute is committed to<br />

collaborating with hospices to enhance<br />

pharmacotherapy outcomes for patients<br />

through education, research and participation<br />

in public policy. As a benefit to hospices, we<br />

provide palliative care educational programs to<br />

enhance practice and career growth for health<br />

care professionals.<br />

“Introduction to Non-opioid and Opioid Pain<br />

Therapy” was offered as a web teleconference<br />

in February. There were 173 hospices<br />

registered for this program. Over 440 health<br />

care professionals received credit for this<br />

continuing education session. This program is<br />

now available online as an independent study.<br />

“Beyond Opioids: Adjuvant Drug Therapy”<br />

was conduced in May. There were 116<br />

hospices registered and over 312 health care<br />

professionals received continuing education<br />

credit for the program!<br />

Most recently in August, we presented<br />

“Pharmacotherapy for the Anxious and<br />

Agitated Patient.” Approximately 200<br />

hospices registered and roughly 900 health<br />

care professionals requested to participate!<br />

Other CNE modules available online are listed<br />

below. Please visit the recently updated CNE<br />

website www.hospicepharmacia.com. The<br />

programs available include:<br />

Palliative Sedation in <strong>Hospice</strong> Patients<br />

Palliative Care in Amyotrophic Lateral<br />

Sclerosis<br />

Palliative Care in Patients with<br />

Dementia<br />

Palliative Care in Huntington’s<br />

Disease<br />

Palliative Treatment of Dyspnea<br />

Management of Seizures in<br />

End of Life Care<br />

The Palliative Management of<br />

Insomnia<br />

Introduction to Non-opioid and<br />

Opioid Pain Therapy<br />

Beyond Opioids: Adjuvant<br />

Drug Therapy<br />

Pharmacotherapy for the Anxious<br />

and Agitated Patient<br />

“Management of Common Gastrointestinal<br />

Complaints at the End of Life,”<br />

will be held on:<br />

• November 8, 2005 at 9:00am EST<br />

• November 9, 2005 at 12:00pm EST<br />

• November 10, 2005 at 3pm EST<br />

Laura Scarpaci, PharmD is the speaker.<br />

She is the Palliative Care Pharmacy Practice<br />

Resident at the University of Maryland,<br />

School of Pharmacy.<br />

This CE program is designed to equip nurses<br />

with the tools needed to manage common<br />

gastrointestinal symptoms encountered at<br />

the end of life such as nausea, vomiting and<br />

diarrhea.<br />

An overview of recent advances will<br />

be provided in addition to a review<br />

of pharmacological agents and nonpharmacological<br />

techniques typically used<br />

in the management of these troubling<br />

symptoms. The presentation will also<br />

incorporate several cases to demonstrate<br />

how the material can be applied to real-life<br />

situations.<br />

After participation in the program, the<br />

audience will be able to:<br />

1. Identify common etiologies associated<br />

with nausea, vomiting, and diarrhea at<br />

the end of life.<br />

2. Differentiate between the available<br />

pharmacological agents for the<br />

treatment of common end-of-life<br />

gastrointestinal symptoms with regards<br />

to their mechanism of action, side<br />

effects, and indications.<br />

3. Create an appropriate drug regimen<br />

based on patient-specific factors and<br />

clinical appropriateness for managing<br />

common end-of-life gastrointestinal<br />

symptoms.<br />

If you would like to learn more about the<br />

excelleRx Institute educational programs,<br />

please contact Dr. Jill Pfeiffenberger,<br />

Director of Education for the excelleRx<br />

Institute, by calling 877.882.7822, ext<br />

1677 or by emailing jillp@excellerx.com.<br />

Register now for<br />

education regarding<br />

<strong>HP</strong>’s Seventh Edition<br />

of the Medication Use<br />

Guidelines!<br />

www.hospicepharmacia.com


Passionate for the Appropriate Use of Medication 3<br />

<strong>HP</strong>’s Seventh Edition of the Medication Use Guidelines<br />

- Douglas J. Weschules, PharmD, BCPS, VP of Clinical Services<br />

<strong>HP</strong> announces the release of the seventh<br />

edition of the Medication Use Guidelines<br />

(MUGs)! excelleRx has been hard at work<br />

for the past twelve months creating this new<br />

volume, and we cannot wait to place it in<br />

your hands. The workload assumed by the<br />

MUGs committee was the most aggressive in<br />

excelleRx’s history, with over 500 hours spent<br />

in the authorship of guidelines, protocols<br />

and monographs alone. Over 40 different<br />

topics were included in the development<br />

of this seventh edition of the MUGs, 28 of<br />

which were suitable for external review. <strong>HP</strong><br />

sincerely thanks each of the 34 development<br />

clinicians and 11 internal review editors and<br />

staff for rising to this challenge.<br />

The changes associated with the seventh<br />

edition of the MUGs are not limited to just<br />

the review topics themselves, however. The<br />

process associated with MUGs development<br />

also continues to mature every year.<br />

Noteworthy examples of this evolution<br />

this year include the development and use<br />

of guideline templates for Development<br />

Clinicians (authors) to follow, as well as the<br />

grading of evidence associated with these<br />

documents.<br />

So, what will you see in this new edition?<br />

Completely new guidelines include:<br />

• Urinary Incontinence<br />

• Bowel Obstruction<br />

• Failure to Thrive/Debility, Unspecified<br />

New medications and therapy options for<br />

existing guidelines include:<br />

• Roxicodone tablets, 15 and 30 mg<br />

• Valproic acid-based SeizureKit<br />

Additional detail and enhancements have<br />

also been added to the following guidelines:<br />

• Alzheimer’s Disease<br />

• Anxiety<br />

• Agitation<br />

• Congestive Heart Failure<br />

• COPD<br />

• Nociceptive Pain<br />

• Urinary Tract Infections<br />

Many medications were reviewed but not<br />

added to the seventh edition of the MUGs,<br />

either because of a lack of evidence to<br />

support their use in the hospice population<br />

or because MUG alternatives exist that are<br />

comparable and/or more cost effective.<br />

Medications included in the external review<br />

process that were not added to the MUGs are<br />

outlined below by reason:<br />

Not enough evidence to support their<br />

addition to the MUGs:<br />

• Antihypertensives for the palliation of<br />

end stage CVA<br />

• Donepezil (Aricept®)<br />

• Galantamine (Razadyne®)<br />

• Hydromorphone sustained-release<br />

(Palladone®)<br />

• Memantine (Namenda®)<br />

• Nebulized dexamethasone for COPD or<br />

dyspnea<br />

• Nebulized lidocaine for cough<br />

• Pregabalin (Lyrica®)<br />

• Tiagabine (Gabitril®)<br />

• Tiotropium (Spiriva®)<br />

• Valproic acid for the management of<br />

agitation associated with dementia<br />

A comparable MUG medication already exists<br />

and/or is more cost-appropriate:<br />

• Albuterol sulfate/ipratropium bromide<br />

(DuoNeb®)<br />

• Citalopram (Celexa®)<br />

• Clopidogrel (Plavix®)<br />

• Dalteparin (Fragmin®)<br />

• Enoxaparin (Lovenox®)<br />

• Levetiracetam (Keppra®)<br />

• Morphine sulfate sustained-release<br />

capsule (Avinza®)<br />

• Olanzapine (Zyprexa®)<br />

• Torsemide (Demadex®)<br />

• Tramadol (Ultram®)<br />

In addition, the following medications were<br />

reviewed internally, but were not part of the<br />

external review process:<br />

• Acetylcysteine (Mucomyst®)<br />

• Carvedilol (Coreg®)<br />

• Magnesuim oxide (Mag Ox®)<br />

• Oral ketamine (Ketalar®)<br />

• Quinine sulfate<br />

As you can see, the external review process<br />

was robust. Many clinicians from partnering<br />

hospices and programs participated in<br />

this process. The vast majority of external<br />

reviewers agreed that each document they<br />

reviewed provided a thorough analysis of<br />

each topic, a complete literature review, and<br />

agreed with the findings of the author. A few<br />

questions and concerns were highlighted<br />

throughout this process, all of which helped<br />

to influence the MUGs committee’s ultimate<br />

decisions for the seventh edition of the<br />

MUGs. If you are interested in participating<br />

in the external review process in the future,<br />

please let us know!<br />

The Seventh Edition of the MUGs will be<br />

mailed to <strong>Hospice</strong> <strong>Pharmacia</strong> partners in<br />

the next several weeks and will be effective<br />

on November 1st, 2005. Information<br />

regarding the preparatory teleconferences<br />

is available on our website.<br />

If you have any questions regarding the<br />

release of the MUGs, or about any of<br />

its content, please contact the MUGs<br />

committee at MUGs@excellerx.com.<br />

www.hospicepharmacia.com


4<br />

Passionate for the Appropriate Use of Medication<br />

excelleRx Supports Care Coordination Solutions Forum for WHCoA<br />

- Diane Jones, MSW, Director of excelleRx Institute<br />

excelleRx joined several national fundraising<br />

organizations in supporting a critical White<br />

House Conference on Aging (WHCoA)<br />

Solutions Forum, Care Coordination<br />

Across the Continuum. The event focused<br />

on articulating cutting edge solutions<br />

rather than repeating the many well-known<br />

problems associated with our current<br />

healthcare system. Held at the Russell Senate<br />

Office Building on July 19, 2005, an expert<br />

panel of 15 luminaries spoke to an audience<br />

comprised of policy makers, non-government<br />

organizations, healthcare industry leaders<br />

and the press.<br />

The Care Coordination Across the Continuum<br />

Solutions Forum was among hundreds of<br />

grass roots events that have been held across<br />

the country over the past year and a half for the<br />

purpose of making recommendations to the<br />

WHCoA Policy Committee for consideration.<br />

The recommendations presented by the<br />

Care Coordination event specifically deal<br />

with healthcare in the final years of life and<br />

envision a healthcare system with seamless<br />

coordination of comprehensive, reliable, and<br />

readily accessible medical care and supportive<br />

services over time and across settings.<br />

Adherence to evidence-based standards and<br />

guidelines for treatments, medication therapy<br />

management, and services, was one of several<br />

critical elements of optimal coordinated care<br />

advanced by the Solutions Forum.<br />

The full report from the Care Coordination<br />

Across the Continuum Solutions Forum can<br />

be downloaded at www.medicaring.org/<br />

whcoa. For information about other activities<br />

of the White House Conference on Aging go<br />

to www.whcoa.gov. If implemented, these<br />

recommendations could have sweeping<br />

impact on the delivery of health care for the<br />

next decade.<br />

JoAnne Reifsnyder, PhD, SVP of Research<br />

and Innovation at excelleRx and Diane Jones,<br />

MSW, Director of the excelleRx Institute<br />

were members of the planning committee.<br />

Jones also coordinated the event.<br />

The White House Conference on Aging<br />

occurs once a decade to make aging policy<br />

recommendations to the President and<br />

Congress, and to assist the public and<br />

private sectors in promoting dignity, health,<br />

independence and economic security of<br />

current and future generations of older<br />

persons. The upcoming White House<br />

Conference on Aging will be the first one<br />

of the 21st century and is scheduled to<br />

take place December 11 – 14, 2005 in<br />

Washington, DC.<br />

Here are two specific steps you can take to<br />

get your voice heard:<br />

• Call the offices of your Congressperson<br />

and Senator, and be sure that their<br />

health staffers are on board. You can<br />

use the online Congressional Directory<br />

to find contact information.<br />

• Use the WHCoA online contact<br />

form and tell them how important it<br />

is that they pay attention to serious<br />

chronic illness, continuity, and<br />

caregiving - and that they follow at<br />

least the recommendations of the Care<br />

Coordination Across the Continuum<br />

Solutions Forum.<br />

HOSPICE FUND-RAISERS...<br />

Attention non-for-profi t hospices and for for-profi t hospice<br />

foundations that are looking for a turn-key fund-raising event: “A<br />

Good Idea” fund-raiser event, featuring singer-song writer Karen-<br />

Taylor Good, may work for you!<br />

If you are unfamiliar with Ms. Good’s talents and abilities either, visit<br />

www.hospicepharmacia.com and click on “<strong>Hospice</strong> Fund-Raiser” or,<br />

attend our annual <strong>Hospice</strong> Appreciation Dinner on Friday September<br />

23rd, where Karen will highlight components of her fundraising ideas.<br />

If you would like to share a good idea for a hospice fund-raiser, send<br />

your idea to <strong>HP</strong>Partners@excelleRx.com!<br />

www.hospicepharmacia.com


Passionate for the Appropriate Use of Medication 5<br />

Dear Laura,<br />

I use <strong>HP</strong>’s Xeris on-line tools often and recently noticed two new<br />

icons on the toolbar. Can you explain what these are for?<br />

Lori<br />

Lori,<br />

I’m glad to hear that you are enjoying the benefits of Xeris<br />

enough to realize its multitude of functions! The first new icon<br />

(the second one up from the bottom on the toolbar) links you<br />

to Gold Standard Multimedia’s Clinical Pharmacology clinical<br />

information database. This on-line database provides extensive<br />

drug information, such as general drug descriptions, product<br />

identification, and patient education. Please refer to the related<br />

article in this newsletter.<br />

The second new icon, which is the very last one on the toolbar, is<br />

our Xeris Help link. This link will provide a demonstration on how<br />

to perform different functions in Xeris. Currently, a demonstration<br />

of the admissions process is posted. We will be adding<br />

demonstrations on profiling medications, discharging patients,<br />

refilling medications, Xeris <strong>Hospice</strong> Administrator functions, and<br />

more! Stay Tuned!<br />

Thanks!<br />

Dear Laura,<br />

I was trying to refill a medication through your Automated<br />

Refill and Discharge System (ARDS) and it prompted me<br />

to enter my PIN after I keyed in my patient’s social security<br />

number. I don’t have a PIN and can’t remember my<br />

password for Xeris. What should I do?<br />

Gwen<br />

Gwen,<br />

The Xeris <strong>Hospice</strong> Administrator (XHA) at your hospice<br />

has enabled your Xeris account for PIN since the system<br />

is prompting you for one. That was the correct thing to<br />

do since you are a nurse and will be using the Medication<br />

Management Support Center (MMSC) and its services.<br />

Please see your XHA so that he or she can reset your<br />

password. You can then use this new temporary password<br />

to login to Xeris and create a PIN. You will need your PIN<br />

any time you call <strong>HP</strong> or use the telephone automation for<br />

one of your patients on service. Please let your XHA know<br />

if you have any questions on the process.<br />

Thanks!<br />

Laura<br />

Laura<br />

Laura Lutz is the Client Development Manager at <strong>Hospice</strong> <strong>Pharmacia</strong>. She is responsible for coordinating implementations<br />

and for supporting new hospice partners as they transition from their current pharmacy providers to <strong>HP</strong>. Laura also helps<br />

with the planning and organization of <strong>HP</strong>’s educational programs, including monthly Xeris training and orientation webteleconferences.<br />

Laura can be reached by emailing <strong>HP</strong>Partners@excelleRx.com.<br />

<strong>Hospice</strong> <strong>Pharmacia</strong> is a service of excelleRx, Inc., an Omnicare Company.<br />

© Copyright 2005 Xeris, Predictive Pharmacotherapy Outcomes System (PPOS), Prospective Medication Management, Medication Use Guidelines (MUGs), ComfortPak, SeizureKit,<br />

<strong>Hospice</strong> <strong>Pharmacia</strong> Collaborative Practice (<strong>HP</strong>CP), and all Xeris products and their respective logos are Trademarks of excelleRx, Inc. All rights reserved. No part of the information<br />

contained herein may be reproduced, duplicated, or copied without permission. Please inquire if you are not sure. PPOS and Xeris are Patent Pending.<br />

www.hospicepharmacia.com


6<br />

Passionate for the Appropriate Use of Medication<br />

<strong>HP</strong> Continues to Enhance Quality While Adding Opportunities for Savings<br />

Streamlined Performance Incentive Program, Added Discount on AWP for Medications Outside<br />

of Protocol, and the Lowest Annual Price Adjustment Ever<br />

- Calvin H. Knowlton, RPh, MDiv., PhD, CEO<br />

<strong>Hospice</strong> <strong>Pharmacia</strong> is very pleased to<br />

announce an enhanced and simplified<br />

Performance Incentive Program (PIP),<br />

effective October 1, 2005, simultaneous<br />

with the launch of the new edition (VII) of<br />

the Medication Use Guidelines. There are<br />

two components to this new PIP, which will<br />

be assessed each month and automatically<br />

applied to your monthly statement.<br />

1. Earn a 0.50% discount for having 85%<br />

of your home care patients assessed for<br />

ComfortPaks.<br />

2. Earn a 0.75% discount for having<br />

a functional interface between your<br />

software and <strong>HP</strong>’s Xeris software. A<br />

functional interface means either an FTP<br />

or HL7 interface whereby >75% of your<br />

referrals/admissions are communicated<br />

successfully via the electronic interface.<br />

We have removed the PIN, outcomes<br />

reporting, and automated refills performance<br />

benchmarks as we have found the reporting<br />

functionality, especially reporting by nurse,<br />

is already a great incentive for hospices to<br />

encourage their staff to use their PIN. The<br />

automated refill system will become much<br />

easier with the introduction of voice to text<br />

technology (targeted for 4q05) where the<br />

nurse may say the patient’s phone number,<br />

the PIN, and the refill number, instead of<br />

having to use the telephone key pad.<br />

Additionally, with the recent merger, wherein<br />

excelleRx became a division of Omnicare, we are<br />

able to take advantage of enhanced purchasing<br />

power on medications that were traditionally<br />

low volume for our organization—basically<br />

the non-MUG medications. Therefore, also<br />

effective October 1, 2005, we will be reducing<br />

the medication price on our non-MUG<br />

medications. Certainly, this is not to encourage<br />

the use of non-MUGs!<br />

<strong>HP</strong>’s per diems are set based upon a hospice’s<br />

percentage of patients with cancer (vs. noncancer)<br />

diagnoses. We have very specific and<br />

detailed information correlating increased<br />

<strong>HP</strong> encounters and medication mix with<br />

higher cancer rates. While we monitor this<br />

information on a quarterly basis, this year has<br />

been significant in that dozens of our hospices<br />

have received a per diem reduction letter from<br />

<strong>HP</strong> because their cancer rate has dropped to<br />

a lower bracket for two consecutive quarters<br />

(e.g., from 45% to 35%).<br />

Finally, every October is when most of our<br />

hospice clients receive an annual per diem<br />

price adjustment. This October will be the<br />

lowest price adjustment in <strong>HP</strong>’s nine year<br />

history—less than half of the 4.4% Producer<br />

Price Index for Opioids (which is what<br />

we use as our upper threshold each year).<br />

Specifically, the <strong>HP</strong> per diem will increase<br />

less than 2%, effective October 1, 2005.<br />

Because AWP (Average Wholesale Price) is<br />

adjusted by pharmaceutical manufacturers,<br />

hospices are left without any controls on drug<br />

pricing in the fee-for-service environment.<br />

<strong>HP</strong>’s documented ability to help hospices<br />

control costs is exemplary considering the<br />

continued double-digit pharmacy increases<br />

experienced in the healthcare industry<br />

today.<br />

So, in addition to our system for Prospective<br />

Medication Therapy Management, our new<br />

economies of scale are helping to hold down<br />

your total pharmacy costs!<br />

“I appreciate all that hospice pharmacia does for us.<br />

I have been involved in hospice care for six years and<br />

I think that <strong>Hospice</strong> <strong>Pharmacia</strong> does a wonderful<br />

job helping the nursing staff to understand what can<br />

sometimes make us feel so lost. Many thanks.”<br />

Partnering <strong>Hospice</strong> Nurse<br />

August, 2005<br />

www.hospicepharmacia.com


Passionate for the Appropriate Use of Medication 7<br />

Research Update<br />

- Terri Maxwell, RN, PhD(c)<br />

Clinical Pharmacology<br />

via Xeris<br />

As you may have read in our last newsletter,<br />

<strong>HP</strong> has entered into a partnership with Gold<br />

Standard Multi-Media. The outcome of this<br />

partnership is that Clinical Pharmacology is<br />

now available through a special subscription<br />

to Xeris users! <strong>Hospice</strong> <strong>Pharmacia</strong> partners<br />

can enjoy a 90-day free trial, that began<br />

August 1, 2005.<br />

With several studies underway, and several in the pipeline, there is a lot happening in the<br />

Research Department. Current study topics include:<br />

• Examining patient response to long-acting opioids measured on a 0-10 pain rating scale;<br />

• Testing and evaluating our “Patient Reported Outcomes Measures” (PROM) system<br />

that uses innovative IVR technology;<br />

• Evaluating the effects of prospective medication therapy management on patient<br />

hospitalizations and after-hours nursing visits in hospice;<br />

• Evaluating factors that predispose hospice patients to experiencing a fall; and<br />

• Describing groups of hospice patients: pediatric patients, patients with heart failure,<br />

and patients with dementia.<br />

We look forward to sharing the findings from these studies in upcoming newsletters.<br />

After the trial period, hospice partners may<br />

continue their access through a discount<br />

program that translates to a savings of up to<br />

75% for any hospice with greater than four<br />

users!<br />

Clinical Pharmacology provides the most<br />

up to date and accurate drug information<br />

available, and features:<br />

• Medication Monographs<br />

• Therapeutic Class Overviews<br />

• Search Capabilities (for medications by<br />

brand/generic, indication, therapeutic<br />

classification, contraindication, adverse<br />

reaction)<br />

• Drug Interaction Reports<br />

• Adverse Reaction Reports<br />

• Product Identification<br />

• Patient Education<br />

Founded in 1993, Gold Standard is a leading<br />

developer of drug information databases,<br />

software, and clinical information solutions.<br />

<strong>HP</strong> is pleased to be able to provide you with<br />

even more resources to facilitate the best<br />

possible patient care.<br />

For more information on this special offering,<br />

email <strong>HP</strong>Partners@excelleRx.com.<br />

Calling All <strong>Hospice</strong> Medical Directors and<br />

Clinical Research Staff:<br />

JOIN US FOR A RESEARCH TELECONFERENCE!<br />

Title: Building the Evidence Base for <strong>Hospice</strong> Symptom<br />

Management: A Research Teleconference for<br />

<strong>Hospice</strong> Medical Directors and Clinicians<br />

Date: Monday, October 24, 2005<br />

Time: 12 pm-1 pm EDT<br />

Objectives:<br />

• Identify gaps in the evidence base for common<br />

symptoms experienced at the end of life.<br />

• Discuss challenges associated with documentation of<br />

outcomes in hospice.<br />

• Describe findings from recent investigations related<br />

to symptom control, epidemiology, and medication<br />

selection in hospice.<br />

Facilitator: Richard Stefanacci DO, MGH, MBA, AGSF,<br />

CMD, Executive Director, University of the Sciences in<br />

Philadelphia Health Policy Institute<br />

www.hospicepharmacia.com


8<br />

Passionate for the Appropriate Use of Medication<br />

“Proven and Safer...”<br />

continued from page 1<br />

“I forgot my PIN!”<br />

- Mark Schreiber, Technical Support<br />

Manager<br />

We are delighted that more than 80%<br />

of our hospice clients are participating<br />

in the PIN (Personal Identification<br />

Number) program. The purpose of the<br />

PIN program is to comply with HIPAA’s<br />

Privacy Rule.<br />

Just a reminder: Even if a hospice team<br />

member does not use Xeris, he or she<br />

still needs a Xeris account in order to<br />

obtain a PIN number, as we establish<br />

and keep record of nurse profiles in<br />

Xeris. Every <strong>HP</strong> hospice has selected<br />

a Xeris <strong>Hospice</strong> Administrator (XHA)<br />

who serves as the Xeris security liaison<br />

between the hospice and <strong>HP</strong>. The XHA<br />

is authorized to create Xeris accounts<br />

and reset Xeris passwords. Since PIN<br />

is managed through Xeris, your XHA is<br />

authorized to reset your PIN, should you<br />

forget it what it is.<br />

You may also consult the Xeris Reference<br />

Manual with questions. An updated<br />

version of this manual may be found<br />

on the Xeris Welcome Page in the “<strong>HP</strong><br />

Announcements” section.<br />

Your Regional Director of Client<br />

Development (RDCD) is available to<br />

assist with any of the above steps. If you<br />

have any further questions regarding<br />

PIN, please contact your RDCD, or email<br />

<strong>HP</strong>Partners@excelleRx.com. If you are<br />

an XHA and require technical assistance,<br />

feel free to contact our Technical Support<br />

team at support@excellerx.com.<br />

• Insomnia: A statistically significant<br />

number of patients receiving temazepam<br />

(a first line therapy for insomnia in the<br />

MUGs) achieved a complete response as<br />

compared with zolpidem (52% vs. 22%,<br />

p < 0.05).<br />

- This finding suggests that <strong>HP</strong>’s first<br />

line therapy of temazepam is more<br />

effective in treating insomnia than<br />

zolpidem, a common medication<br />

that is used outside of the insomnia<br />

protocol.<br />

• Nausea: A statistically significant<br />

proportion of patients receiving<br />

prochlorperazine (<strong>HP</strong>’s first line therapy<br />

for nausea) achieved a complete response<br />

as compared to patients taking oral<br />

ondansetron, an expensive alternative<br />

commonly prescribed in the oncology<br />

community (48.9% vs. 26.7%; p < 0.05).<br />

The study also found a striking difference<br />

between patient groups that experienced<br />

worsened nausea control after initiating<br />

therapy (8.9% for prochlorperazine vs.<br />

26.7% for ondansetron, p < 0.05).<br />

- This finding suggests that<br />

ondansetron is not superior to<br />

prochlorperazine, in treating<br />

nausea that is secondary to an<br />

unknown etiology (e.g. not receiving<br />

chemotherapy or radiation).<br />

We launched the aforementioned study<br />

to test the hypothesis that <strong>HP</strong>’s evidencebased<br />

Medication Use Guidelines are<br />

associated with better hospice and patientrelated<br />

outcomes. Our findings suggest<br />

that evidence-based prescribing using the<br />

MUGs produces better patient outcomes<br />

when compared to “preference-based”<br />

prescribing.<br />

In addition, while this study was not<br />

constructed to analyze the cost-effectiveness<br />

of the symptom management medications<br />

selected for analysis, it is noteworthy that<br />

<strong>HP</strong>’s first-line therapies in this study are<br />

less costly than the non-MUG medications<br />

to which they were compared.<br />

These findings support the application of<br />

the MUGs as evidence-based guidelines<br />

that both improve symptom management<br />

and assure cost-appropriate medication<br />

selection for hospice patients, especially<br />

when applied under the prescriberdirected,<br />

pharmacist-driven Collaborative<br />

Practice model.<br />

The bottom line: When the right medication<br />

is selected the first time and the patient is<br />

monitored for therapeutic and potential or<br />

actual adverse effects, patients are not just<br />

more comfortable, they experience greater<br />

safety from untoward adverse medication<br />

outcomes. “Proven and safer”—goals that<br />

should concern every one of us—are within<br />

reach and available to our health care<br />

system’s frailest patients including those<br />

who are receiving hospice care as they<br />

approach the end of life.<br />

1<br />

Leape, L.L. , and Berwick, D.M. (2005). Five years<br />

after To Err is Human: What have we learned? JAMA,<br />

293 (19), 2384-2390.<br />

2<br />

Kohn, K.T., Corrigan, J.M., & Donaldson, M.<br />

(1999). To err is human: Building a safer health care<br />

system. Washington, DC: National Academy Press.<br />

excelleRx <strong>Newsletter</strong> Staff<br />

Editor In Chief:<br />

Orsula Voltis, PharmD, MBA<br />

Chief Marketing Officer<br />

orsula@excelleRx.com<br />

Managing Editor:<br />

Dana Filippoli<br />

Senior Director of Marketing<br />

dfilippoli@excelleRx.com<br />

Layout and Design:<br />

Melissa Morris<br />

Graphic Designer<br />

www.hospicepharmacia.com

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