Brandi K. Ormerod, PhD - Biomedical Engineering - University of ...

Brandi K. Ormerod, PhD
Assistant Professor
J. Crayton Pruitt Family Department of Biomedical Engineering
Room JG296, Biomedical Sciences Building
University of Florida
Gainesville, FL, 32611
Phone: 352-273-8125, Fax: 352-273-9221
Web: stemcell.bme.ufl.edu, Email: bormerod@bme.ufl.edu
Employment
Assistant Professor (Tenure Track)
Director – Ormerod Laboratory of Stem Cell Research
J. Crayton Pruitt Family Department of Biomedical Engineering
Joint Faculty in Neuroscience
Since November 2006
Research in the Ormerod Laboratory strives to regenerate or repair neural circuits damaged by disease or
injury using endogenous or transplantable stem cells to reverse the associated cognitive deficits. Projects in
the Ormerod Laboratory employ culture systems to understand how to generate appropriate neural cell
subtypes using stem cells and to promote their functional integration into damaged neural circuits. Animal
models are employed to understand and engineer the niches that promote neuron production in the adult brain
and the relationship between neuron addition and cognition.
Techniques used include histology, immunohistochemistry, confocal and fluorescent/transmitted light microscopy, realtime
PCR, cell isolation/culture (stem cell assays, microelectrode array assays, vascular/NPC co-cultures), proteomics
(Bioplex multiplex fluorokine assays), statistical analyses, behavioral assays, animal models of human disease.
Education and Research Experience
Michael J. Fox Foundation and NSERC Postdoctoral Fellow
Mentor: Dr. Theo D. Palmer
Laboratory of Stem Cell Sciences, Neurosurgery Department, Stanford University, Palo Alto, CA, USA
05/2003 – 11/2006
Main Project: Disentangled the positive and negative impacts of neuroinflammation on the behavior of
endogenous and transplantable/transplanted neural progenitor cells and the impact of the effects on cognition.
Techniques used include, immunohistochemistry, histology, confocal and light microscopy, cell isolation/culture (human
and non-human primate and rodent neural progenitors, endothelial cells, smooth muscle cells, neurons and astrocytes),
real-time PCR, rodent stereotaxic surgery, Barnes maze, water maze, exploration, posturing, rotation.
NSERC, Killam and Alzheimers predoctoral fellow
PhD in Neuroscience
Mentor: Dr. Liisa Galea
Behavioral Neuroendocrinology Laboratory, Psychology Department and Neuroscience Program,
The University of British Columbia, Vancouver, BC, Canada
09/1998 – 05/2003
Thesis: Characterized the effects of estradiol and other systemic factors on the production and survival of new
neurons in produced in the hippocampal dentate gyri of adult rodents and their effects on cognition.
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Techniques used include immunohistochemistry, confocal and light microscopy, gonadectomy/adrenalectomy,
endocrinology, stereotaxic surgery, water maze, radial maze, porsolt swim test, t-maze.
Bachelor of Science (Honours) in Biopsychology
Mentor: Dr Richard Beninger
Neurotransmitter and Behavior Lab, Department of Psychology, Queen’s University, Kingston, ON, Canada
09/1996 – 08/1998
Thesis: Water maze versus radial maze: differential performance of rats in a spatial delayed match-to-position
task and response to scopolamine. This work examined the impact of manipulating memory systems on
performances across tasks and other work investigated the neuropharmacology of reward-related learning.
Techniques used include stereotaxic surgery, histology, water maze, radial maze, conditioned place preference, operant
memory task, conditioned reward, double-Y maze.
Undergraduate Research Assistant
Mentor: Dr. Ronald Weisman
Laboratory of Avian Bioacoustics, Queen’s University, Kingston, ON
05/1997-05/1998
Experience: Investigated the development of song in black-capped chickadees and zebra finches using
immunohistochemical analysis, song analysis software and isolate chick rearing.
Peer Reviewed Journal Articles
1. Maden, M, Manwell, LA, Ormerod BK (Epub 2013). Proliferation zones in the axolotl brain and
regeneration of the telencephalon. Neural Development. JCR Impact Factor 3.700.
2. Speisman, RB, Kumar A, Rani A, Pastoriza JM, Severance JE, Foster TC and Ormerod BK (2013).
Environmental enrichment restores neurogenesis and rapid acquisition in aged rats. Neurobiology
of Aging, 34(1):263-274. JCR Impact Factor 6.634.
3. Bañuelos, C, LaSarge, CL, McQuail J, Hartman JJ, Gilbert RJ, Ormerod BK, Bizon JL (2013). Agerelated
changes in rostral basal forebrain cholinergic and GABAergic projection neurons:
relationship with spatial impairment.Neurobiology of Aging, 34:845-862. JCR Impact Factor 6.634.
4. Ogle,WO, Speisman, RB, and Ormerod BK, (2013). Potential of treating age-related depression
and cognitive decline with nutraceutical approaches: A mini-review. Gerontology, 59:23-31. Current
JCR Impact Factor 2.203.
5. Speisman, RB, Kumar A, Rani A, Foster TC and Ormerod BK (2013). Daily exercise improves
memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune
cytokines in aging rats. Brain, Behavior and Immunity, 28:25-43. JCR Impact Factor 4.720.
6. Lee SW, Haditsch U, Cord BJ, Guzman R, Kim SJ, Boettcher C, Priller J, Ormerod BK, Palmer TD
(Epub 2012). Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial
irradiation. Brain Behav Immun. JCR Impact Factor 4.720.
7. Ormerod BK, Hanft SJ, Asokan A, Haditsch U, Lee SW, Palmer TD (Epub 2012). PPARγ activation
prevents impairments in spatial memory and neurogenesis following transient illness. Brain,
Behavior and Immunity. JCR Impact Factor 4.720.
8. Speisman, RB, Kumar A, Rani A, Foster TC and Ormerod BK (2013). Daily exercise improves
memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune
cytokines in aging rats. Brain, Behavior and Immunity, 28:25-43. JCR Impact Factor 4.720.
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9. Munikoti VV, Hoang-Minh, LB and Ormerod BK (2012). Enzymatic digestion improves the purity of
harvested cerebral microvessels.. Journal of Neuroscience Methods 207:80-85. JCR Impact Factor
2.100.
10. Stephens CL, Toda H., Palmer TD, DeMarse TB, Ormerod BK (2012). Adult neural progenitor cells
reactivate superbursting in mature neural networks. Experimental Neurology, 234:20-30. JCR
Impact Factor 4.436.
11. Bruijnzeel AW, Bauzo RM, Munikoti VV, Yamada H, Ormerod BK, Fornal CA, Jacobs BL (2011).
Tobacco smoke diminishes neurogenesis and promotes gliogenesis in the dentate gyrus of
adolescent rats. Brain Research. 1413:32-42. JCR Impact Factor 2.263.
12. Chen Z, Phillips LK, Gould E, Campisi J, Lee SW, Ormerod BK, Zwierzchoniewska M, Martinez
OM, Palmer TD (2011). MHC mismatch inhibits neurogenesis and neuron maturation in stem cell
allografts. PLoS One 6:e14787. JCR Impact Factor 4.411.
13. Seifert AW, Ormerod BK, Cohn MJ (2010). Sonic hedgehog controls growth of external genitalia by
regulating cell cycle kinetics. Nature Communications. 1:23. Estimated JCR Impact Factor 15.
14. Stratmann G, May LD, Sall JW, Alvi RS, Bell JS, Ormerod BK, Rau V, Hilton JF, Dai R, Lee MT,
Visrodia KH, Ku B, Zusmer EJ, Guggenheim J, Firouzian A (2009). Effect of hypercarbia and
isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats. Anesthesiology,
110:849-861. Current JCR Impact Factor 5.486.
15. Keravala A, Ormerod B.K., Palmer TD, Calos M (2008). Long-term gene expression in mouse
neural progenitor cells modified with PhiC31 integrase. Journal of Neuroscience Methods, 173:299-
305. Current JCR Impact Factor 2.100.
16. Ormerod BK., Palmer TD and Caldwell MA (2008). Neurodegeneration and cell replacement.
Philosophical Transactions of the Royal Society B: Biological Sciences, 363; 153-170. Current JCR
Impact Factor 6.05.
17. Buckwalter MS, Yamane M., Coleman B.S., Ormerod BK, Chin J.T., Palmer TD, Wyss-Coray T.
(2006). Chronically increased transforming growth factor-beta1 strongly inhibits hippocampal
neurogenesis in aged mice. American Journal of Pathology, 169:154-164. Current JCR Impact
Factor 5.224.
18. Nagy AI, Ormerod BK, Mazzucco C. and Galea LAM. (2006) Estradiol-Induced Enhancement in
Cell Proliferation is mediated through Estrogen Receptors in the Dentate Gyrus of Adult Female
Rats. Drug Development Research, 66; 1-8. Current JCR Impact Factor 1.109.
19. Hill MN, Patel S, Carrier EJ, Rademacher DJ, Ormerod BK, Hillard CJ, Gorzalka BB (2005)
Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable
stress. Neuropsychopharmacology. 30:508-15 Current JCR Impact Factor 6.685.
20. Ormerod BK, Lee TT-Y and Galea LAM (2004) Estradiol enhances neurogenesis in the dentate gyri
of adult male meadow voles by increasing the survival of young neurons. Neuroscience, 128: 645-
654. Current JCR Impact Factor 3.215.
21. Ormerod BK, Falconer EM and Galea LAM (2003). NMDA receptor activity and estradiol: Separate
regulation of cell proliferation in the dentate gyrus of adult female meadow voles. Endocrinology,
179:155-163. Current JCR Impact Factor 4.993.
22. Ormerod BK and Galea LAM (2003). Reproductive status influences the survival but not production
of new cells in the dentate gyrus of adult male meadow voles. Neurosci Letters, 346:25-28. Current
JCR Impact Factor 2.055.
23. Ormerod BK, Lee TT-Y and Galea LAM (2003). Estradiol enhances but subsequently suppresses
(via adrenal steroids) granule cell proliferation in the dentate gyrus of adult female rats. J Neurobio
(now Developmental Biology), 55, 247-260. Current JCR Impact Factor 4.094.
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24. Ormerod BK, Beninger RJ (2002). Water maze versus radial maze: differential performance of rats
in a spatial delayed match-to-position task and response to scopolamine. Behav Brain Res, 128,
139-152. Current JCR Impact Factor 3.393.
25. Ormerod BK and Galea LAM (2001). Reproductive status regulates cell proliferation and survival in
the dentate gyrus of adult female meadow voles: A possible role for estradiol. Neurosci, 102, 369-
379. Current JCR Impact Factor 3.215.
26. Galea LAM, Wide JK, Paine TA, Holmes MM, Ormerod BK, and Floresco SB (2001). High levels of
estradiol disrupt conditioned placed preference learning, stimulus response learning and reference
memory but have limited effects on working memory. Behav Brain Res, 126, 115-126 Current JCR
Impact Factor 3.393.
27. Beauchamp M., Ormerod BK, Jhamandas K, Boegman RJ and Beninger RJ (2000). Neurosteroids
and reward: Allopregnanolone produces a conditioned place aversion in rats. Pharm, Biochem,
Behav, 67, 29-35. Current JCR Impact Factor 2.624.
28. Galea LAM, Ormerod BK, Sampath S, Kostaras X, Wilkie D.M. and Phelps M. (2000). Spatial
working memory and hippocampal size across pregnancy in rats. Hormones and Behavior, 37, 86-
95. Current JCR Impact Factor 4.218.
Book Chapters
1. Peltier J, Ormerod B.K. and Schaffer D.V. (2010). Isolation of adult hippocampal neural progenitors.
In Irina Conboy, David Shaffer, Mary Helen Barcellos-Hof, Song Li (Eds.) Methods in Molecular
Biology, 621:57-63.
2. Ormerod B.K. and Galea L.A.M. (2001). Mechanisms and function of neurogenesis in the adult. In
C. A. Shaw and J. C. McEachern (Eds.) Toward a Theory of Neuroplasticity. Taylor and
Francis:Philadelphia. Chapter 8; pages 85-100.
3. Ormerod B.K., Falconer E.M. and Galea L.A.M. (2002). Neurogenesis in adult animals. In Lynn
Nadel (Ed.). Encyclopedia of Cognitive Sciences, Chapter 389; pages 299-305. Macmillan
Publishers Ltd (Nature Publishing Group): England.
Invited Talks
1. Ormerod, BK (2012) Central and circulating cytokine correlates of neurogenesis and cognition in
young and aged rodents. Annual Winter Conference on Neural Plasticity (Frigate Bay, St. Kitts and
Nevis).
2. Ormerod BK (2012) – Neuroinflammation, Neurogenesis and Cognition Across Lifespan. Neurology
Department (University of Florida, FL).
3. Ormerod BK (2012) - Preserving cognitive function: biomarkers of cognitive decline. Annual
University of Florida McKnight Foundation Research Symposium (Gainesville, FL).
4. Ormerod BK (2011) - Recent advances in adult hippocampal neurogenesis research.
Developmental Neurobiology GMS 6073 graduate class (Gainesville, FL).
5. Ormerod BK (2011) - An introduction to adult hippocampal neurogenesis. Developmental
Neurobiology GMS 6029 graduate class (Gainesville, FL).
6. Ormerod BK (2010) - Neuroinflammation influences neural progenitor cell fate early after division.
Duke University Neurology Department (Durham, NC).
7. Ormerod BK (2010) - So now you are a graduate student – now what? BME Graduate Student
Orientation (Gainesville, FL).
8. Ormerod, BK (2009). PPARу Activation prevents defects in spatial memory and hippocampal
neurogenesis following transient illness. Sir Wilfred Laurier Department of Psychology Behavioral
Neuroscience (Seminar Kitchener-Waterloo, Canada).
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9. Ormerod BK (2009) - Developing biomarkers for unsuccessful cognitive aging. Annual University of
Florida McKnight Foundation Research Symposium (Gainesville, FL).
10. Ormerod (2009) - Studying stem cell strategies for brain repair. University of Florida HHMI Science
for Life Seminar Series (Gainesville, FL).
11. Ormerod BK (2009) – How to succeed in graduate school. BME Graduate Student Orientation
(Gainesville, FL).
12. Ormerod BK (2008) - NSAIDs rescue hippocampal neurogenesis and memory: Implications for
stem cell strategies and neurodegenerative disease. Case Western Reserve Regenerative
Medicine Program (Cleveland, Ohio).
13. Ormerod, BK (2008) - NSAID treatment can reverse inflammation-induced deficits in adult
neurogenesis and spatial memory. International Behavioral Neuroscience Society Meeting (St.
Thomas, USVI).
14. Ormerod BK (2008) - Adult neurogenesis and hippocampus-dependent memory can be rescued
from the effects of neuroinflammation by the appropriate NSAID. University of Florida Neuroscience
Department (Gainesville, FL).
15. Ormerod BK (2008) - Neural progenitor cells, neuroinflammation and NSAIDs: Implications for
treating neurodegenerative disease. Annual University of Florida Biomedical Engineering Inductrial
Advisory Board Committee Meeting (Gainesville, FL).
16. Ormerod BK (2008) – Graduate work and research. University of Florida Biomedical Engineering
Society Student Brown Bag Lunch (Gainesville, FL).
17. Ormerod BK (2007) – Things to know as a new assistant professor at the University of Florida.
College of Engineering New Faculty Orientation Workshop (Gainesville, FL).
18. Ormerod BK (2007) - Stem cells and brain repair. Annual University of Florida Biomedical
Engineering Industrial Advisory Board Meeting (Gainesville, FL).
19. Ormerod BK (2007) - The appropriate NSAID treatment protects hippocampal neurogenesis and
memory from neuroinflammation. Conference on Data Mining, Systems Analysis and Optimization
in Biomedicine (University of Florida, FL).
20. Ormerod BK (2006) - Long-term consequences of transient illness on adult neurogenesis and
memory can be prevented by NSAID treatment. University of Florida Regenerative Medicine
Program (Gainesville, FL).
21. Ormerod BK (2006) - Stem Cells and Neurodegenerative Disease. Department of Biomedical
Engineering Seminar Series. (Gainesville, FL).
22. Ormerod BK (2006) – Regenerating the brain. University of Florida Biomedical Engineering Invited
to present to the Biomedical Engineering Department (Gainesville, FL).
23. Ormerod (2005) - Behavior: What’s neurogenesis got to do with it? Presented at the Quarterly Ben
Barres, Irv Weissman, Joint Alvarez-Buylla and Palmer Stem Cell Research Lab Meeting
(University of San Francisco, CA).
24. Ormerod BK (2004) – Neuroinflammaton ablates neurogenesis in the adult CNS and impairs
behavior: Implications for inducing neurogenesis in the substantia nigra. Annual Michael J. Fox
Foundation Advisory Board Fellows Meeting (New York, NY).
25. Ormerod BK (2003) – Inflammation and the neurogenic niche. Annual Michael J. Fox Foundation
Advisory Board Fellows Meeting (New York, NY).
26. Ormerod BK (2003) - Do estradiol-induced changes in neurogenesis affect hippocampusdependent
behaviour? Stanford Biology Department (Palo Alto, CA).
27. Ormerod, BK (2002) - Estradiol influences the production and survival of new neurons in the
dentate gyrus of adult rodents. Neurosurgery Department, Stanford University (Palo Alto, CA).
28. Ormerod BK (2002) - Hormones, stress and adult neurogenesis: Do more new neurons mean better
learning? Presented by LAM Galea, JK Wide, BK Ormerod and EM Falconer as a UBC
Neuroscience Laboratory Colloquium (Vancouver, BC).
29. Ormerod BK and Galea LAM (2000) - Reproductive status regulates cell proliferation in the dentate
gyrus of adult female meadow voles, probably through estradiol. Presented by Ormerod at the
International Behavior Development Society Meeting (Minot, ND).
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30. Ormerod BK (2000) - Both cell proliferation and cell survival are influenced by reproductive status in
the dentate gyrus of adult female meadow voles. Workshop on Neurogenesis in Natural
Populations (Toronto, Ont).
Proceedings
1. Seifert AW, Ormerod BK, Cohn MJ (2010). Sonic hedgehog regulates cell cycle kinetics during
morphogenesis. Developmental Biology 331:498.
2. Zachrisson O, Andersson A, Isacson R, Jeldes S, Mercer A, Nielsen E, Patrone C, Ronnholm H,
Wikstrom LB, Di Monte DA, McCormack AL, Ormerod BK, Palmer TD, Zhao M, Delfani KK, Janson
Lang AM and Haegerstrand A (2008). Neurorestorative effects of PDGF-BB in models of Parkinson s
disease through stimulation of cell proliferation. Movement Disorders, 23:S155-163.
Published Abstracts
1. Speisman RB, Asokan A, Rani A, Kumar A, Foster TC, and Ormerod BK (2012). Age related changes in
central and circulating cytokines and their relationship to learning and memory. Annual Society for
Neuroscience Meeting, Vol. 37: 243.07 (New Orleans, LA).
2. Hoang-Minh, L.B., Posada, A.M. and Ormerod B.K. (2011). Day- versus night-induced variations in adult
female mouse hippocampal neurogenesis may be related to changes in gene expression between day
and night. Society for Neuroscience Abstr Vol 36. 858.01.
3. Stephens C.L., DeMarse, T.B. and Ormerod, B.K. (2011). Adult neural progenitor cells influence cell
survival and ensemble activity following oxygen-glucose deprivation on microelectrode arrays. Society
for Neuroscience Abstr Vol 36. 331.21.
4. Speisman R.B., Kumar A., Rani, A., Foster T.C., and Ormerod B.K. (2011). Circulating and central
inflammatory cytokines linked to hippocampal neurogenesis; both modified by running in aged rats.
Society for Neuroscience Abstr Vol 36. 331.20.
5. Asokan, A., Ball, A., Laird C., Hermer, L., Ormerod B.K. (2011). The fast acting anti-depressant
desvenlafaxine promotes new granule neuron maturation in the dentate gyrus of adult rats. Society for
Neuroscience Abstr Vol 36. 331.19.
6. Speisman RB, Kumar A, Rani A, Foster TC, and Ormerod BK. (2011). Running alters cytokine levels in
the blood serum, cortex and hippocampus of aged rats. International Brain Research Organization
World Congress Abstracts. Florence, Italy.
7. Sandhu, M.S., Ross, H.H., Dougherty, Laywell E.D. Ormerod BK, Reier, P.J, Fuller D.D. (2010).
Respiratory changes following transplantation of post-natal neural precursors into high cervical
hemilesions of the adult rat. Society for Neuroscience Abstr Vol 35. 469.8.
8. Asokan A, Chandran M., Khargonekar P.P. and Ormerod B.K. (2010). A combined multiplex
experimental and modeling approach reveals candidate neuroinflammatory cytokines that affect
hippocampal progenitor cell behavior in adult mice. Society for Neuroscience Abstr Vol 35. 638.9.
9. Hoang-Minh L. and Ormerod B.K. (2010). Day/night variations in neurogenesis may be due to changes
in cell cycle kinetics in the dentate gyrus of adult. Society for Neuroscience Abstr Vol 35. 638.19.
10. Speisman R.B., Kumar, A. Rani A., Severence J.E, Foster T.C., Ormerod B.K. (2010). Enrichment
concomitantly improves hippocampal neurogenesis and spatial memory in aged rats. Society for
Neuroscience Abstr Vol 35. 710.10.
11. Stephens CL, DeMarse TB, Ormerod BK (2010). Adult neural progenitor cell addition after oxygenglucose
deprivation on microelectrode arrays influences recovery of network activity. Society for
Neuroscience Abstr Vol 35; 760.8.
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12. Munikoti VV, Asokan A and Ormerod BK (2010). Hippocampal neurogenesis and laminin expression
are inversely regulated by lipopolysaccharide-induced neuroinflammation in adult female mice. Society
for Neuroscience Abstr Vol 35; 839.15.
13. Seifert AW, Ormerod BK, Cohn MJ (2009) Sonic hedgehog controls growth of external genitalia by
regulating cell cycle kinetics. Dev Bio, 331: 498.
14. Stephens CL, DeMarse TB, Ormerod BK (2009). Spontaneous activity patterns of fetal and adult neural
networks are altered by the addition of adult neural progenitor cells. Soc Neurosci Abstr Vol 34, 324.13.
15. Asokan A and Ormerod BK. (2009). Lipopolysaccharide induced activation of circulating inflammatory
molecules exert a negative influence on hippocampal progenitor cell differentiation in the adult brain.
Soc for Neurosci Abstr Vol 34.
16. Hanft S, Ormerod BK, Lee SW, Palmer TD (2009). The promise of NSAID therapy in patients receiving
cranial radiation: is there hope for cognitive sparing? American Association of Neurological Surgeons
Annual Meeting. San Diego, CA.
17. Ormerod BK, Speisman RB, Kumar A, and Foster TC. (2009) Biomarkers predict successful versus
unsuccessful aging in rats. Society for Neuroscience Abstr Vol 34. 535.14. 1.
18. Seifert A, Ormerod BK, Cohn MC (2008). Shh controls growth by regulating cell cycle kinetics. Dev
Biology Meeting. Annual Latin American Society for Developmental Biology Meeting, Buenos Aires.
19. Ormerod BK, Hoang-Minh L, Kelly P, Jones BE, Palmer TD (2008). Is there a circadian effect on cell
production in extra-hippocampal adult brain regions? Society Neuroscience Abstracts, Vol 33. 324.1.
20. Asokan A, Ormerod BK (2008) A bioplex strategy for identifying candidate molecules that affect adult
hippocampal neurogenesis. Society Neuroscience Abstracts, Vol 33. 423.25.
21. Stephens CL, DeMarse TB, Ormerod BK (2008). Neural progenitor cells influence and are influenced
by the activity of primary neurons cultured on microelectrode arrays. Society Neuroscience Abstracts,
Vol 33. 738.8.
22. Zachrisson O, Andersson A, Isacson R, Jeldes S, Mercer A, Nielsen E, Patrone C, Ronnholm H,
Wikstrom LB, Di Monte DA, McCormack AL, Ormerod BK, Palmer TD, Zhao M, Delfani KK, Janson
Lang AM and Haegerstrand A. (2008). Neurorestorative effects of PDGF-BB in models of Parkinson s
disease through stimulation of cell proliferation. Presented by Zachrisson at The Movement Disorder
Society. Chicago, IL.
23. Zachrisson O, Andersson A, Isacson R, Jeldes S, Mercer A, Nielsen E, Patrone C, Ronnholm H,
Wikstrom LB, Di Monte DA, McCormack AL, Ormerod BK, Palmer TD, Zhao M, Delfani KK, Janson
Lang AM and Haegerstrand A. (2007). Neurorestorative effects of PDGF-BB in rodent models of
Parkinson s disease through stimulation of cell proliferation. Society Neuroscience Abstracts, Vol 32.
797.1.
24. Ferguson MC, Rani A, Kumar A, Foster TC, Ormerod BK (2007). Neurogenesis is enhanced in the
hippocampus of young and aged rats exposed to an enriched versus impoverished environment.
Society Neuroscience Abstracts, Vol 32. 566.70.
25. Stephens CL, DeMarse TB, Ormerod BK (2007). Fetal and adult neural progenitor cells develop
network-wide activity: a 60 channel microelectrode array analysis. Society Neuroscience Abstracts Vol
32. 344.80.
26. Ormerod BK., Lee SW, Cord BJ, Palmer TD (2006). Absence of monocyte chemoattractant protein-1
protects neurogenesis in response to cranial irradiation. Society Neuroscience Abstracts Vol 31.
385.16.
27. Meltzer L, Ormerod B., Palmer T, Deisseroth K (2005). Driving activity-dependent neurogenesis via L-
Type Calcium Channels: Circuit-level and behavioral consequences. Society Neuroscience Abstracts
Vol 31. 141.69.
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28. Ormerod BK, Hanft S, Palmer TD (2005). NSAID treatment protects adult hippocampal neurogenesis
and hippocampus-dependent behavior from the deleterious effects of neuroinflammation. Soc Neurosci
Abstr Vol 31., 141.70.
29. Price RO. Chang THT, Gandal MJ, Ormerod, BK, Palmer T.D. (2005). Fetal cortical neurogenesis is
disrupted by maternal inflammation. Annual Meeting of the International Society for Stem Cell Research
(San Francisco, CA). Volume 4.
30. Ormerod BK, Hanft SJ, Palmer TD (2005). Neuroinflammatory blockade rescues inflammation-induced
deficits in adult hippocampal neurogenesis and hippocampus-dependent memory. Annual Meeting of
the International Society for Stem Cell Research (San Francisco, CA). Volume 4.
31. Price RO, Ormerod BK, Palmer TD (2004). Maternal inflammation during fetal brain development
disrupts cortical neurogenesis. Soc. Neurosci. Abstr Vol. 30., 831.90.
32. Hill MN, Carrier E, Patel S, Ormerod BK, Hillard C, Gorzalka BB (2003). Chronic stress elicits
differential regulation of cannabinoid type 1 (CB1) receptor binding and expression in the hippocampus
and limbic forebrain. Soc. Neurosci. Abstr., Vol 29., 829.18.
33. Ormerod BK, Falconer EM and Galea LAM (2003). More new neurons survive in the dentate gyrus of
adult estradiol- versus vehicle-treated female meadow voles. Soc. Neurosci. Abstr., Vol 29., 671.13.
34. Nagy AI, Ormerod BK, Mazzucco C.M. and Galea L.A.M. (2003). Estradiol-induced enhancement of
granule cell proliferation is mediated via the ERa. Soc. Neurosci. Abstr., Vol 29., 348.50.
35. Wide J.K, Ormerod BK and Galea LAM (2002). Chronic estradiol treatment does not influence cell
proliferation in the dentate gyrus of adult female rats. Soc. Neurosci. Abstr., Vol 28, 470.11.
36. Ormerod B.K., Lee T.T-Y and Galea L.A.M. (2002). Adult male meadow voles with estradiol-enhanced
numbers of young neurons exhibit better spatial memory. Soc. Neurosci. Abstr., Vol 28, 470.10.
37. Ormerod B.K., Lee T.T-Y. and Galea L.A.M. (2001). Estradiol initially enhances but subsequently
suppresses (via adrenal steroids) cell proliferation in the dentate gyrus of adult female rats. Soc.
Neurosci. Abstr., Vol 27, 587.6.
38. Ormerod B.K., Witheford M and Galea L.A.M. (2001). Estradiol enhances the survival of 6-10 day old
neurons in the dentate gyrus of adult male meadow voles. P05-013 Stem Cells in the Mammalian
Brain.
http://www.neuroscion.com/forum/discussions?action=browse&col=stemcells&group=stemcells.poster5
&expanded=&fromthr=11&tothr=16
39. Hofmann C.E., Piaseczna M.A., Ormerod B.K., Floresco S.B., Holmes M.M. and Galea L.A.M. (2000).
Caudate but not hippocampus lesions impair acquisition on a cued arm task. Soc. Neurosci. Abstr., Vol
26, 650.4.
40. Ormerod B.K. and Galea L.A.M. (2000). Estradiol initially enhances but subsequently suppresses cell
proliferation in the dentate gyrus of adult female meadow voles. Soc. Neurosci. Abstr., Vol 26, 847.12.
41. Galea LAM, Paine TA, Piaseczna M and Ormerod B.K. (1999). Estradiol inhibits learning in a
hippocampal-dependent task but enhances learning in a hippocampal-independent task and promotes
cell survival in the dentate gyrus. Soc. Neurosci. Abstr., Vol 25, 863.5.
42. Ormerod BK and Galea LAM (1999). Survival of newly born cells in the dentate gyrus of adult meadow
voles, Microtus pennsylvanicus, is influenced by reproductive status. Soc. Neurosci. Abstr., Vol 25,
863.4.
43. Westly JK, Ormerod BK and Beninger RJ (1998). Inhibition of protein kinase in the nucleus accumbens
impairs amphetamine-produced enhancement of responding for conditioned reward. Soc. Neurosci.
Abstr., Vol 24, 72.8.
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Other Scientific Presentations
1. Munikoti VV, Fonts JA, Ormerod BK (2012). Neuroinflammation-induced vascular remodeling may
compromise neuronal differentiation. Annual Biomedical Engineering Society Meeting (Atlanta,
Georgia).
2. Ormerod BK, Stephens CL, DeMarse TB (2012). Adult neural progenitor cells partially protect
mature MEA-plated neuronal networks from OGD-induced death and silencing. Annual Biomedical
Engineering Society Meeting (Atlanta, Georgia).
3. Speisman RB, Asokan A, Rani A, Kumar A, Foster TC, and Ormerod BK (2012). A Multiplex
Approach for Designing a Biomarker Assay for Age-related Cognitive Decline. Annual Biomedical
Engineering Society Meeting (Atlanta, Georgia).
4. Speisman RB, Asokan A, Rani A, Kumar A, Foster TC, and Ormerod BK (2012). Age related
changes in central and circulating cytokines and their relationship to learning and memory. Evelyn
F. McKnight Brain Research Foundation Poster Reception at the Society for Neuroscience 07 (New
Orleans, LA).
5. Munikoti VV and Ormerod BK (2012). Neuroinflammation may compromise hippocampal
neurogenesis through its effects on vasculature. Pruitt Research Day at the University of Florida
Biomedical Engineering Department (Gainesville, FL).
6. Hoang-Minh L and Ormerod BK (2012). Sleep/wake changes in gene expression may mediate
sleep/wake changes in hippocampal neurogenesis in adult mice. Pruitt Research Day at the
University of Florida Biomedical Engineering Department (Gainesville, FL).
7. Asokan A and Ormerod BK (2012). Lipopolysaccharide-induced neuroinflammation impacts central
and circulating cytokines and hippocampal neurogenesis in adult mice. Pruitt Research Day at the
University of Florida Biomedical Engineering Department (Gainesville, FL).
8. Speisman RB, Rani A, Kumar A, Foster TC, and Ormerod BK (2012). Daily exercise improves
memory, increases hippocampal neurogenesis and modulates immune and neuroimmune
cytokines. McKnight Brain Institute Spotlight on Aging Research (Gainesville, FL).
9. Posada AM, Hoang-Minh LB, Ormerod BK (2012). Pyknotic cell death does not affect differences in
the number of dividing NPCs quantified during the night versus day. HHMI Undergraduate
Research Conference (Gainesville, FL).
10. Speisman RB, Rani A, Kumar A, Foster TC, and Ormerod BK. (2011). Circulating and central
inflammatory cytokines linked to hippocampal neurogenesis; both modified by running in aged rats.
Evelyn F. McKnight Brain Research Foundation Poster Reception at the Society for Neuroscience
(Washington, DC).
11. Speisman RB, Kumar A, Rani A, Foster TC, and Ormerod BK (2011). Exercise stimulates
hippocampal neurogenesis and modulates circulating and central cytokines in aged rats. Society for
Developmental Biology Southeast Regional Meeting abstracts. Gainesville, Fl.
12. Speisman RB, Kumar A, Rani A, Foster TC, and Ormerod BK. (2011). Running alters cytokine
levels in the blood serum, cortex and hippocampus of aged rats. International Brain Research
Organization World Congress Abstracts (Florence, Italy).
13. Speisman RB, Kumar A, Foster TC, and Ormerod BK. (2011). Enrichment concomitantly improves
hippocampal neurogenesis and spatial memory in aged rats. University of Florida Graduate Student
Council Interdisciplinary Research Conference (Gainesville, FL).
14. Zheng Z, Evans K, Garcia C, Ormerod BK, Cohn MJ (2010). Genetic basis of sexual dimorphism in
external genitalia and brain development. 2nd World Conference on the Hormonal and Genetic
Basis of Sexual Differentiation Disorders and hot Topics in Endocrinology. Miami, FL.
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15. Speisman RB, Kumar A, Foster TC, and Ormerod BK. (2010). Identifying Biomarkers to Predict
Cogntive Aging in Rats. University of Florida Graduate Student Council Interdisciplinary Research
Conference (Gainesville, FL).
16. Noutong, SA, Su J, Hoang-Minh, LB, Ormerod BK (2010). Astrocyte quantification in the white and
gray matter of the mouse brain. HHMI Undergraduate Research Conference (Gainesville, FL).
17. Speisman RB, Kumar A, Rani A, Pastoriza JM, Severence JE, Foster TC and Ormerod BK. (2010).
New granule neuron number relates to mnemonic performance in control but not all enriched rats.
NSF Research Day at the University of Florida (Gainesville, FL).
18. Speisman RB, Kumar A, Foster TC, and Ormerod BK. (2009). Using biomarkers to predict
successful versus unsuccessful aging in rats. Annual Florida Genetics Meeting (CGRC, Gainesville,
FL).
19. Asokan A, Ormerod BK (2009). Discovering cytokines that affect adult hippocampal neurogenesis.
J Crayton Pruitt department of Biomedical engineering graduate student recruitment day poster
session (Gainesville, FL).
20. Asokan A. and Ormerod BK. (2009). Candidate inflammatory molecules that affect adult
hippocampal neurogenesis. University of Florida Graduate Student Council Interdisciplinary
Research Conference (Gainesville, FL).
21. Hoang-Minh L, Palmer TD and Ormerod BK (2009). Effects of the Circadian Cycle on Neurogenesis
in the Hippocampus and Substantia nigra. University of Florida Graduate Student Council
Interdisciplinary Research Conference (Gainesville, FL).
22. Stephens CS, Ormerod BK, DeMarse TB (2009). The Addition of Adult Neural Progenitor Cells
Influences Network Activity. University of Florida Graduate Student Council Interdisciplinary
Research Conference (Gainesville, FL). **Stephens won a $500 first place poster award.
23. Pastoriza JM, Ferguson M, Kumar A, Foster TC, Ormerod BK (2009). Exposure to an enriched
environment increases neurogenesis in elderly rats. HHMI Celebration of Undergraduate Creativity
in the Arts & Sciences Conference (Gainesville, Fl).
24. Kojic Z, Ogle WO, Foster TC, Ormerod BK (2009). Can exposure to an enriched environment
reverse possible age-associated changes in mitochondrial number and status? HHMI Celebration of
Undergraduate Creativity in the Arts & Sciences, (Gainesville, Fl).
25. Garcia CV, Zheng P, Ormerod BK (2009). The effects of endocrine-disrupting chemicals on brain
development. University Scholars Program Symposium. (Gainesville, FL).
26. Asokan A and Ormerod BK (2009). Candidate inflammatory molecules that affect adult
hippocampal neurogenesis. University of Florida Graduate Student Council Interdisciplinary
Research Conference (Gainesville, FL).
27. Stephens CS, DeMarse TB, Ormerod BK (2008). Adult neural progenitor cells influence network
activity. Annual Florida Genetics Meeting (CGRC, Gainesville, FL).
28. Munikoti V, Ormerod BK (2008). Is adult neurogenesis a product of the vascular environment?
Annual Florida Genetics Symposium (CGRC, Gainesville, FL).
29. Stephens CS, DeMarse TB, Ormerod BK (2008). Functional neurons derived from adult neural
progenitors influence primary neural networks: A 60-channel microelectrode array analysis.
University of Florida Graduate Student Council Interdisciplinary Research Conference. Gainesville,
FL.
30. Asokan A, Ormerod BK (2008). LPS-induced inflammation produces neuroinflammation that
influences neural progenitor cell behavior. University of Florida Graduate Student Council Research
Day Conference. Gainesville, FL.
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31. Hill M.N., Gorzalka B.B., Carrier E., Patel S., Ormerod B.K., Hillard C. (2003). Enhancement of
responsiveness to cannabinoid agonists following chronic stress. Annual Meeting of the Canadian
Society for Brain, Behaviour and Cognitive Sciences (Hamilton, Ont).
32. Hill M.N., Patel S., Carrier E., Gorzalka B.B., Ormerod B.K., Hillard C. (2003). Chronic stress
sensitizes the anxiogenic response induced by acute cannabinoid administration. 13th Annual
Meeting of the International Cannabinoid Research Society.
33. Nagy A., Ormerod B.K., and Galea L.A.M. (2003) Estradiol enhances neurogenesis in the dentate
gyrus of adult female rats through the ER. Annual Meeting of the Canadian Society for Brain,
Behaviour and Cognitive Sciences.
34. Ormerod B.K., Lee T.T-Y. and Galea L.A.M. (2002). Estradiol increases the number of 6-10 day old
hippocampal neurons and improves memory in adult male rodents. Annual Meeting of the Canadian
Society for Brain, Behaviour and Cognitive Sciences.
35. Ormerod B.K. and Galea L.A.M. (2001). Estrogen influences the birth and survival of new neurons
in the hippocampus of adult rodents. Annual Meeting of the Canadian Society for Brain, Behaviour
and Cognitive Sciences (Vancouver, BC).
36. Ormerod B.K. and Galea L.A.M. (1999). Photoperiod and reproductive status influence cell
proliferation rate in the dentate gyrus of adult meadow voles, Microtus Pennsylvanicus. Annual
Meeting of the Canadian Society for Brain, Behaviour and Cognitive Science (Quebec, Ontario).
37. Ormerod B.K. and Beninger R.J. (1998). Spatial delayed match-to-position: A comparison of the
water and radial mazes. Annual Meeting of the Canadian Society for Brain, Behaviour and
Cognitive Science (Ottawa, Ontario).
Press Releases
2011 – Discovery News Interview. “'Brain in a dish' may lead way to stroke recovery”. Interview was based on
Stephens et al., 2012. http://www.msnbc.msn.com/id/43593811/ns/technology_and_science-science/t/braindish-may-lead-way-stroke-recovery/
2010 - Press Release. "Sluggish cell division may help explain genital defects." ScienceDaily, 1 Jun. 2010.
Web. 6 Jun. 2012. Based on Seifert et al., 2010
http://www.sciencedaily.com/releases/2010/06/100601124133.htm.
Teaching Experience
Classroom
Undergraduate
BME 3323L/5052L “Cellular Engineering Laboratory”
(developed Module 1 in 2011/taught Spring terms since 2011)
Module 1 (8 weeks-long) consisted of a 50min lecture, 2-3h laboratory sessions and a 30-min cell feeding
session weekly. Students cultured neural stem cells for the experiment that they designed, executed and wrote
up in IEEE Transactions in BME format. Lectures exposed the students to academic and industrial BME
culture systems, laboratory safety, human and animal cell regulatory oversight, aseptic technique and Good
Manufacturing Practice. Lab notebook write-ups, research homework, group discussions/presentations, an
exam and final written reports were graded. With ABET accreditation in mind, I generated lectures,
laboratories, a laboratory manual and a teaching manual.
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EML 4930 “An Introduction to Biomedical Engineering”
(developed Summer 2007/ co-taught Fall 2007).
EML 4930 introduced undergraduate students to BME research topics. BME Faculty members introduced a
BME topic in 2 lectures and then their related research in a 3rd lecture. Weekly assignments describing lecture
material promoted regular attendance and exams tested the students’ understanding of both lecture and
textbook material. I believe that had we re-taught this course, improved organization, presenter flow and
communication of course objectives would have improved student evaluations.
Graduate
BME 6938a – “Foundations of Neural Engineering – BME Repair Strategies”
(developed spring 2008/taught each Fall)
This course was designed to introduce neural-track BME graduate students to the brain and behavioral
neuroscience because many were repeating the advanced courses offered by the Neuroscience Department.
The presentation/discussion format lets modify the content difficulty to fit their diverse backgrounds. I employ
power point talks, chalk talks and movies to introduce basic concepts behind the topics we discuss. The
students’ advanced talks incorporated these topics with their engineering backgrounds and published literature
to propose BME strategies for CNS repair.
BME 6938b “Stem Cell Engineering”.
(developed fall 2008/taught each Spring)
Discussion-based Stem Cell Engineering overviews stem/progenitor cells (i.e. embryonic, adult, SCNT-derived
iPSCs), their history and politics, current funding priorities and regulatory policies, stem cell strategies,
preclinical and clinical data and patient-directed approaches. I employ power point slides, chalk talks and
published visual protocols (i.e. JOVE) and then the students then give talks that introduce a specific
stem/progenitor cell (i.e. hematopoietic) and then how to use them to treat a clinical problem (i.e. delivering
vaccine) using BME principles.
BME 8654 – “Problem Based Learning”
(taught fall 2008)
In one of the final 2 BME 8654 sections, I facilitated the independent learning of students tasked with
developing a potentially patentable biomedical device by promoting group discussion and research about
market analysis, patent searches, product design, prototyping and marketing by having them work as a
corporate team. The students cohesively researched, designed and prototyped a lightweight cast for setting
field injuries.
Teaching Assistant Experience
1998 – 2001 Laboratory Instructor for 2 nd year Fall Term Biopsychology Laboratory at UBC
1998 – 2001 Teaching Assistant for 2 nd year Fall and Summer Term Psychology of Gender Course at UBC
1998 – 2001 Teaching Assistant for 3 rd year Spring Term Biopsychology Course at UBC
2001 – 2002 Teaching Assistant for 4 th year Spring Term Neuroplasticity Course at UBC
2001 – 2002 Teaching Assistant for 3 rd year Fall Term Statistics Course at UBC
1997 – 1998 Undergraduate Teaching Assistant for 4th yr Behavioral Pharmacology Course at Queen’s
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Names and Locations of Current and Past Trainees
Current Trainees
Graduate
Vikram Munikoti PhD Expected August 2013
Aditya Asokan PhD Expected August 2013
James McGuiness PhD Expected May 2018
Undergraduate
Chris Lee Since 2011
Anna Denadel Since 2012
Past Trainees
Graduate Students
From Current Position
Robin Price, MD/PhD 2003-2006 Director of Medical Affairs, Covidien
Melissa Ferguson, M.S. 2006-2007 Quality Control R&D Proctor & Gamble
Crystal Stephens, PhD 2006-2012 Systems Engineer Ventana Medical Systems
Lan Hoang-Minh, PhD 2007-2012 Post-doctoral fellow Sarkisian Lab at UF
Rachel Speisman, PhD 2008-2013 Post-doctoral fellow Herkenham Lab at NIH
Ray Kozikowski , PhD 2010-2012 Scientist at Ventana Medical Systems
Alessandro Tovaglieri, MS 2011-2012 Research Assistant Breault Lab at Harvard
Rotating Medical Scholars Trained
Simon Hanft, M.D. 2003-2006 Chief Neurosurgery Resident Columbia
Visiting Scholars Trained
Laurie Manwell, PhD 2010 Wilfred Laurier University, Post Doc
Davide D’Amico, M.Sc. 2007-2008 U Madrid Graduate Prog. in Neuroscience
Magda Mahlstedt, PhD 2004-2005 U Nottingham Stem Cell Prog Fellow
Elizabeth Blackwood, PhD 2005 Genentech
Undergraduate Students Trained
HHMI Science For Life Winner 1 , University Scholars Program Winner 2 , Completed Honors Thesis work under Dr. Ormerod’s Supervision 3
Name
Yrs Trained Current Location
Tracie Paine, PhD 3 1999-2001 Assistant Professor, Oberlin College
Robert Saona, M.D. 1999-2002 Clinical Instructor Medicine, UBC
Jennifer Wide, M.D. 3 1999-2002 Priv. psychiatry practice Vancouver, BC
Miranda Richter, PhD 3 2000-2003 Postdoctoral work, Roskams Lab, UBC
Tiffany Lee, MSc. 2000-2002 PhD Student, Gorzalka Lab, UBC
Lyndsay Murrow, PhD 2004-2006 Research Scientist Lipkowitz Lab NIH
Margaret Lin 3 , B.Sc. 2004-2006 UCSF Medical School
Peter Kelly, B.Sc. 2006-2007 U Maryland Dental School
Jessica Pastoriza1,2,3 B.S. 2007-2009 Albert Einstein Medical School
Britta Jones 1,2 B.S. 2006-2008 UNC Neurology Graduate School
Kelly Jones 2007-2008 UF Engineering Undergrad Program
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Zorana Kojic, B.A. 2007-2009 Graduate Student UF
Cristina Garcia 1,2,3 , B.A. 2007-2010 UCF Medical School
Christina Laird 1 , B.S. 2008-2009 UF Pharmacy Sciences Grad School
Crystal Rocher 1 B.A. 2008-2010 Sanford-Burnham Biotech MSc Program
Ellen Crim, B.S. 2008-2010 Cornell Veterinary School
Christina Bonarrigo 1,2 2008-2010 UF Undergraduate Political Science
Alan Ball 3 , B.A. 2008-2010 Peace Corps
Steven Noutong 1 , B.A. 2009-2011 UF Medical School
Jamie Severence 2009-2010 UF Biology Program
James Su 1 2009-2012 Johns Hopkins BME Graduate Program
Lexi Barrett 2010-2011 UF Undergrad Biology
Donovan Welch 2010-2011 UF Undergrad Engineering Program
Angie Posada 1,2 2011-2012 Interviewing Biotech Master’s Programs
Jordi Fonts3 2010-2012 U Miami Medical School
Rotating Medical and Neuroscience Graduate Students
Colin McLeod 2010 Summer UF Medical School
Steven Chrzanowski 2011 Summer UF MD/PhD Program
Emily Dabe 2011 Fall Neuroscience IDP
Reviewer for Scholarly Journals
Behavioral Processes, Biological Psychiatry, Brain Research Bulletin, Current Medicinal Chemistry (1 this past
year), European Journal of Neuroscience, Experimental Gerontology (2 this past year), Experimental
Neurology (2 this past year), Frontiers in Aging Neuroscience (1 this past year), Genes, Brain and Behavior
International Journal of Developmental Neuroscience (1 this past year), Journal of Alzheimers Disease (1 this
past year), Journal of Developmental Neurobiology, Journal of Neurochemistry (1 this past year), Journal of
Neuroinflammation (1 this past year), Molecular and Cellular Neuroscience, Nature, Neurobiology of Aging (2
this past year), Neuroscience (2 this past year), Neuroscience Letters (1 this past year), Neuroscience
Research, Neuropsychopharmacology, Neurosignals, Neurotoxicology (1 this past year), Nutritional Disorders
and Therapy (1 this past year), Physiology and Behavior, PlosOne (3 this past year), Proceedings of the
National Academy of Sciences, Science
Memberships
Since 1998 - Society For Neuroscience
Since 1998 - Canadian Association for Neuroscience
Since 1998 – Canadian Society for Brain, Behavior and Cognitive Science
Since 1998 – International Brain Research Organization
Since 2000 – Women in Neuroscience
Since 2000 - Cajal Club
Since 2006 – Biomedical Engineering Society
Since 2008 – International Behavioral Neuroscience Society
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Committees
2010/11 Biomedical Engineering Lecturer Search Committee
2011 Biomedical Engineering Health and Safety Committee
Since 2010 Ad Hoc Reviewer for the US-Israel Binational Science Foundation
Since 2010 Ad Hoc Reviewer - Korean Agency for Science, Technology & Research (A*Star)
2010 Biomedical Engineering Awards Committee
2010 Biomedical Engineering New Building Committee
2009 Biomedical Engineering Department New Faculty Search Committee
2009 Biomedical Engineering Department Chair Search Committee
2009 Neuroscience Department New Faculty Search Committee
2008/9 New Equipment Co-ordinator for New Biomedical Sciences Building
(shopped, generated quotes, sole sourced, received and arranged assembly and
training for > $800,000 worth of equipment).
2009 Biomedical Engineering New Faculty Search Committee
Since 2009 Ad Hoc Reviewer NSF - Integrative Organismal Systems Section
2007 The Federation of Cloning and Aging webpage content editor
2007 Ad Hoc reviewer for U Washington Alzheimers Disease Research Center Grants
Since 2007 Member Maryland-Funded TEDCO Stem Cell Grant Competition Review Panel
Since 2006 UF Biomedical Engineering Department Blood Borne Pathogens Training Officer
2006–2009 Biomedical Engineering Department Academic Committee
Honors and Awards
1998 Faculty of Graduate Studies Travel Award (UBC; CDN$400)
1999 Natural Sciences and Engineering Research Council of Canada Scholarship A (UBC; $34,600)
2001 Natural Sciences and Engineering Research Council of Canada Scholarship B (UBC; $38,400)
2001 Killam Predoctoral Fellowship (UBC; CDN$44,000 - $24,000 top-up accepted)
2001 Killam Predoctoral Fellowship Travel Award (UBC; CDN$1,500)
2001 Alzheimers Society of Canada Predoctoral Fellowship (UBC; CDN$44,000 – declined)
2002 Invited to introduce UBC president Dr. Martha Piper at the Inaugural Nobel Awardee Michael
Smith Honorary “Women at the Frontiers of EXXcellence” Conference opening ceremony
2003 UBC Brain Research Centre “3D Microscopy of Living Cells Course” scholarship (US$2,250)
2003 Society for Neuroscience Chapters Travel Award (US$735)
2003 Michael J. Fox Foundation Postdoctoral Fellowship (US$78,000)
2003 NSERC of Canada Post Doc Fellowship (Stanford; $40,000)
2003 NIH CHOC Human Embryonic Stem Cell Course (Burnham Institute; Scholarship Bursary; $1,500)
2004-2006 Chair of the Stanford Brain Food Bimonthly Seminar Series
2007 UF College of Engineering Faculty Track Graduate Student Mentor
Current Funding
Existing Research Support
07/10 – 08/14
5R37 AG036800-02 Signaling cascades and memory deficits during aging
The National Institutes of Health (NIA)
Amount - $1,174,210
Ormerod (Co-PI: 2.7 months)
15

Goal: The goal of this research is to understand how age-related changes in circulating and central cytokines
impact NMDA receptor activity and cognition.
03/13 – 03/17
PR121769 - Translational Advancement of Somatostatin Gene Delivery for Disease Modification and Cognitive
Sparing in Intractable Epilepsy
The Department of Pharmacology and Therapeutics – Department of the Army (DoD)
Amount - $1,500,000
Ormerod (multiple PI – 3 months)
Goal: The goal of this research is to investigate the efficacy and safety of centrally delivered somatostatin on
epilepsy in a rat model.
05/12 – 12/12
Light-triggered Carrier Drug Release for Treatment of Disseminated Cancer
Bankhead-Coley
Amount - $78,896
Ormerod – PI (1 month)
09/10 – 09/13
DGE-0802270 Using Biomarkers to predict successful versus unsuccessful aging in rats.
National Science Foundation predoctoral fellowhip to R.B.Speisman
Amount - $90,000
Ormerod (mentor)
05/11 – 08/11
Axolotl neurogenesis following brain injury
NSERC/SSHERC/CIHR Canada Tri-Council Michael Smith Foreign Study Fellowship to L.A. Manwell
Amount - $6,000
Ormerod (mentor)
Pending Research Support
04/13 – 04/17
Proteomic analysis of cytokines modulating adult neurogenesis and memory
Funding Agency – The National Institutes of Health (NIGMS)
Amount - $1,438,059
Ormerod (PI: 3 months)
Goal: The goal of this research is to understand how lipopolysaccharide-stimulated peripheral and central
cytokines impact hippocampal neurogenesis in young mice treated with broad spectrum and specific antiinflammatory
strategies.
02/13 – 02/14
Relationships between olfactory/hippocampal neurogenesis and age-related memory loss
UF McKnight Brain Research Institute – Age-related memory loss panel
Amount - $100,000
Ormerod (PI: 1 month)
16

Goal: The goal of this research is to understand whether olfactory bulb neurogenesis declines concomitantly
with hippocampal neurogenesis in aged rats and whether distinct or common inflammatory correlates can be
identified.
Past Research Support
2010 – 2012
Biomarkers of successful and unsuccessful aging
McKnight Brain Institute – Age-related Memory Loss Panel
Amount - $50,000
Ormerod - PI
The major goal of this award is to explore how neuroinflammation interacts with neurogenesis to produce agerelated
cognitive decline in rodents.
2008 – 2010
Neural stem cells and inflammation: Implications for Alzheimers disease
Ruth K. Broad Biomedical Research Foundation Extramural Award
Amount - $180,000
Ormerod - PI
The major goal of this award is to understand how inflammation is transduced into neuroinflammation and to
identify candidate inflammatory molecules that impact neural progenitor/stem cell behavior.
2007
Construction of the first two-photon based laser scanning epifluorescence microscope at the University of
Florida: A cross-college and multidisciplinary effort.
University of Florida College of Medicine Seed Fund
Amount - $100,000
Ormerod (Co-PI – 5%)
The major goal of this award is complete construction of a system that will stimulate cross disciplinary
collaboration using techniques for imaging live cells otherwise unavailable to UF researchers.
2007-2009
#FF20 - The effects of chromosomal sex and developmental age on cultured and transplanted neural
progenitor cells
McKnight Brain Institute – McKnight Brain Research Foundation
Amount - $50,000
Ormerod - PI
The major goal of this award is to determine parameters that promote optimal engraftment of stem cells into
the diseased or damaged brain with emphasis on minimizing inflammation.
17