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Cell-Based Assays for Hepatotoxicity:

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HCS222<br />

Detecting changes in neuron biomarkers due to toxins<br />

Neurons & astrocyte co-culture<br />

untreated (Control)<br />

blue = nuclei<br />

green = III-tubulin (neurons)<br />

red = GFAP (astrocytes)<br />

Neurons & astrocyte co-culture treated<br />

with H 2<br />

O 2<br />

(toxin)<br />

Significant damage to neurons<br />

blue = nuclei<br />

green = III-tubulin (neurons)<br />

red = GFAP (astrocytes)<br />

1mM H 2 O 2

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