barcelona . spain - European Association for the Study of the Liver

BARCELONA . SPAIN
66 POSTGRADUATE COURSE SYLLABUS ALCOHOLIC LIVER DISEASE 67
APRIL 18 - 19/2012 THE INTERNATIONAL LIVER CONGRESS TM 2012
Figure 3
The Fibrotest® (Biopredictive, Paris, France) score was determined using the following equation:22 4.467
log [A2M (g/L)] - 1.357 log [haptoglobin (g/L)] + 1.017 log [GGT (IU/L)] + 0.0281 x [age (years)] + 1.737 x
log [bilirubin (μmol/L] - 1.184 x [Apo-A1 (g/L)] + 0.301 x gender (female = 0, male = 1) - 5.540.
The Fibrometer® (BioLiveScale, Angers, France) score was calculated as follows:6 -0.169 PT (%) + 0.015
A2M (mg/dL) + 0.032 HA (μg/L) - 0.140 age (years) + 16.541.
The PGA & -PGAA indices were calculated by adding the 4 laboratory parameters (PT, GGT, Apo-A1 and
A2M) scored on a 0-4 scale according to published methods.3,13
The APRI was calculated as described elsewhere.16
Blood hyualuronic acid levels were measured with a immunoenzymatic assay.
Lastly, the Hepascore logistic regression model was calculated using the following equation:18 y = exp
[-4.185818 - (0.0249 x age) + (0.7464 x gender) + (1.0039) x A2M) + (0.0302 x HA) + (0.0691 x bilirubin) -
(0.012 x GGT)]. The Hepascore is defined as y/1+y.
Figure 4
Figure 6
Figure 5