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barcelona . spain - European Association for the Study of the Liver

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BARCELONA . SPAIN<br />

134 POSTGRADUATE COURSE SYLLABUS ALCOHOLIC LIVER DISEASE 135<br />

APRIL 18 - 19/2012 THE INTERNATIONAL LIVER CONGRESS TM 2012<br />

a transplant, even after excluding patients who are still actively drinking 13 . In this study, HCC was not<br />

significantly associated with adherence to guidelines. The potential prejudice <strong>of</strong> <strong>the</strong> general public and<br />

<strong>of</strong> some medical pr<strong>of</strong>essionals towards <strong>the</strong>se patients probably induces a generally worse prognosis <strong>for</strong><br />

alcohol-related HCC compared to virally-related HCC.<br />

Figure 3: Simplified scheme <strong>of</strong> <strong>the</strong> mechanisms involved in ALD -related carcinogenesis (adapted from<br />

Seitz H.K. et al. 9 )<br />

Figure 1: Total <strong>of</strong> adults (aged 15+) per capita consumption <strong>of</strong> alcohol (L <strong>of</strong> pure alcohol), in 2005 2<br />

REFERENCES<br />

Figure 2: Odds ratio <strong>for</strong> HCC according to alcohol intake and <strong>the</strong> presence <strong>of</strong> HBV or HCV, obtained by<br />

fitting spline regression models that included age and residence as covariates, in <strong>the</strong> Brasilia HCC study 7 .<br />

Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.<br />

Global status report on alcohol and death. www.who.int/substance.../global_alcohol<br />

report/msbgsrupr<strong>of</strong>iles.pdf, 2011.<br />

Contains major reference about alcohol consumption in <strong>the</strong> world and by country.<br />

Cochrane J, Chen H, Conigrave KM, et al. Alcohol use in China. Alcohol Alcohol 2003;38:537-42.<br />

Corrao G, Ferrari P, Zambon A, et al. Are <strong>the</strong> recent trends in liver cirrhosis mortality affected<br />

by <strong>the</strong> changes in alcohol consumption Analysis <strong>of</strong> latency period in <strong>European</strong> countries.<br />

J Stud Alcohol 1997;58:486-94.<br />

Hepatitis B. http://www.who.int/csr/disease/hepatitis/whocdscsrlyo20022/en/index.html, 2002.<br />

Deuffic-Burban S, Deltenre P, Louvet A, et al. Impact <strong>of</strong> viral eradication on mortality related<br />

to hepatitis C: a modeling approach in France. J Hepatol 2008;49:175-83.<br />

Donato F, Tagger A, Gelatti U, et al. Alcohol and hepatocellular carcinoma: <strong>the</strong> effect<br />

<strong>of</strong> lifetime intake and hepatitis virus infections in men and women. Am J Epidemiol 2002;155:<br />

323-31.<br />

Contains pro<strong>of</strong> <strong>of</strong> dose effect <strong>for</strong> alcohol consumption and additive effect <strong>of</strong> HCV<br />

or HBV infection.<br />

Bosch FX, Ribes J, Diaz M, et al. Primary liver cancer: Worldwide incidence<br />

and trends. Gastroenterology 2004;127:S5-S16.<br />

Seitz HK, Stickel F. Molecular mechanisms <strong>of</strong> alcohol-mediated carcinogenesis.<br />

Nat Rev Cancer 2007;7:599-612.<br />

Major review about molecular mechanism <strong>of</strong> alcohol-related carcinogenesis.<br />

Hernandez-Vargas H, Lambert MP, Le Calvez-Kelm F, et al. Hepatocellular carcinoma<br />

displays distinct DNA methylation signatures with potential as clinical predictors.<br />

PLoS One 2010;5:e9749.<br />

Derambure C, Coulouarn C, Caillot F, et al. Genome-wide differences in hepatitis C- vs<br />

alcoholism-associated hepatocellular carcinoma. World J Gastroenterol 2008;14:1749-58.<br />

Herold C, Regn S, Ganslmayer M, et al. Can quantitative tests <strong>of</strong> liver function discriminate<br />

between different etiologies <strong>of</strong> liver cirrhosis Dig Dis Sci 2002;47:2669-73.<br />

Julapalli VR, Kramer JR, El-Serag HB. Evaluation <strong>for</strong> liver transplantation: adherence to<br />

AASLD referral guidelines in a large Veterans Affairs center. <strong>Liver</strong> Transpl 2005;11:1370-8.

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