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barcelona . spain - European Association for the Study of the Liver

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BARCELONA . SPAIN<br />

110 POSTGRADUATE COURSE SYLLABUS ALCOHOLIC LIVER DISEASE 111<br />

APRIL 18 - 19/2012 THE INTERNATIONAL LIVER CONGRESS TM 2012<br />

Gassul MA, Short- and long-term outcome <strong>of</strong> severe alcohol-induced hepatitis treated with<br />

steroids or enteral nutrition: a multicenter randomized trial. Hepatology, 2000. 32: p. 36-42.<br />

Hart, C.L., et al., Effect <strong>of</strong> body mass index and alcohol consumption on liver disease:<br />

analysis <strong>of</strong> data from two prospective cohort studies. BMJ, 2010. 340: p. c1240.<br />

Mendenhall CL, A.S., Garcia-Pont P, Goldberg S, Kiernan T, Seef LB, Sorrell M,<br />

Tamburro C, Weesner R, Zetterman R, Chedid A, Chen T, Rabin L, Short-term and<br />

long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone.<br />

N Engl J Med, 1984. 311: p. 1464-1470.<br />

Mathurin P, O.G.J., Cari<strong>the</strong>rs RL, Phillips M, Louvet A, Mendenhall CL, Ramond MJ,<br />

Naveau S, Maddrey WC, Morgan TR, Corticosteroids improve short-term survival in patients<br />

with severe alcoholic hepatitis: meta-analysis <strong>of</strong> individual patient data. Gut, 2011. 60: p. 255-260.<br />

Daures JP, P.P., Bories P, Blanc P, Youfsi A, Michel H, Gremy F., Place de la corticothérapie<br />

dans le traitement des hépatites alcooliques aiguës. Résultats d’une méta-analyse.<br />

Gastroenterol Clin Biol, 1991. 15: p. 223-8.<br />

Imperiale TF, M.A., Do corticosteroids reduce mortality from alcoholic hepatitis<br />

Ann Intern Med, 1990. 113: p. 299-307.<br />

Reynolds TB, Corticosteroid <strong>the</strong>rapy <strong>of</strong> alcoholic hepatitis: how many studies it will take<br />

Hepatology, 1990. 12: p. 619-621.<br />

Imperiale TF, O.C.J., McCullough AJ, Corticosteroids are effective in patients with severe<br />

alcoholic patients. Am J Gastroenterol, 1999. 94: p. 3066-3067.<br />

Akriviadis E, B.R., Briggs W, Han S, Reynolds T, Shakil O, Pentoxifylline improves<br />

short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled<br />

trial. Gastroenterology, 2000. 119: p. 1637-1648.<br />

Lebrec D, T.D., Oberti F, Perarnau JM, Condat B, Barraud H, Saliba F, Carbonell N,<br />

Renard P, Ramond MJ, Moreau , Poynard T, Pentoxifylline does not decrease short-term<br />

mortality but does reduce complications in patients with advanced cirrhosis. Gastroenterology,<br />

2010. 138(5): p. 1755-1762.<br />

Krishna De B, G.S., Dutta D, Baksi SD, Pani A, Ghosh P, Pentoxifylline versus prednisolone<br />

<strong>for</strong> severe alcoholic hepatitis: a randomized controlled trial. World J Gastroenterol, 2009. 15(13):<br />

p. 1613-1619.<br />

Louvet A, D.E., Dharancy S, Coevoet H, Texier F, Thévenot T, Deltenre P, Canva V,<br />

Plane C, Mathurin P, Early switch to pentoxifylline in patients with severe alcoholic<br />

hepatitis is inefficient in non-responders to corticosteroids J Hepatol 2008. 48: p. 465-470.<br />

Spahr L, R.-B.L., Pugin J, Giostra E, Frossard JL, Borisch B, Hadengue A, Rapid changes<br />

in alcoholic hepatitis histology under steroids: correlation with soluble intercellular<br />

adhesion molecule-1 in hepatic venous blood. J Hepatol, 2001. 35: p. 582-589.<br />

Naveau S, C.-M.S., Dharancy S, Mathurin P, Jouet P, Piquet MA, Davion T, Oberti F, Broët P,<br />

Emilie D, A double blind randomized controlled trial <strong>of</strong> infliximab associated with prednisolone<br />

in acute alcoholic hepatitis. Hepatology, 2004. 39: p. 1390-1397.<br />

Boetticher NC, P.C., Kwo P, Abrams GA, Patel T, Aqel B, Boardman L, Gores GJ, Harmsen<br />

WS, McClain CJ, Kamath PS, Shah VH, A randomized, double-blinded, placebo-controlled<br />

multicenter trial <strong>of</strong> etanercept in <strong>the</strong> treatment <strong>of</strong> alcoholic hepatitis. Gastroenterology,<br />

2008. 135(6): p. 1953-60.<br />

Moreno C, L.P., Hittelet A, Lasser L, Degre D, Evrard S, Colle I, Lemmers A, Deviere J,<br />

Le Moine O, Enteral nutrition with or without N-acetylcysteine in <strong>the</strong> treatment <strong>of</strong> severe<br />

acute alcoholic hepatitis: a randomized multicenter controlled trial. J Hepatol, 2010. 53(6):<br />

p. 1117-1122.<br />

Nguyen-Khac E, T.T., Piquet MA, Benferhat S, Goria O, Chatelain D, Tramier B,<br />

Dewaele F, Ghrib S, Rudler M, Carbonell N, Tossou H, Bental A, Bernard-Chabert B,<br />

Dupas JL, Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis. N Engl J Med,<br />

2011. 365(19): p. 1781-1789.<br />

Dew, M.A., et al., Meta-analysis <strong>of</strong> risk <strong>for</strong> relapse to substance use after transplantation<br />

<strong>of</strong> <strong>the</strong> liver or o<strong>the</strong>r solid organs. <strong>Liver</strong> Transpl, 2008. 14(2): p. 159-72.<br />

Mathurin P, M.C., Samuel D, Dumortier J, Salleron J, Durand F, Castel H, Duhamel A,<br />

Pageaux GP, Leroy V, Dharancy S, Louvet A, Boleslawski E, Lucidi V, Gustot T,<br />

Francoz C, Letoublon C, Castaing D, Belghiti J, Donckier V, Pruvot FR, Duclos-Vallee JC,<br />

Early liver transplantation <strong>for</strong> severe alcoholic hepatitis. N Engl J Med, 2011. 365(19): p. 1790-800.<br />

Figure 1<br />

Meta-analysis <strong>of</strong> individual patient data (n=418) from five RCTs comparing corticosteroid treatment with<br />

placebo, enteral nutrition or an antioxidant cocktail. Estimated 28-day survival according to treatment in<br />

(A) complete responders to corticosteroids (Lille score 0.56). From Mathurin P et al. Gut 2011 [25] with permission.

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