Faculty of Pharmacy

(ECZ728) FORMULATION DESIGN AND QUALITY CONTROL PROCESS OF
HERBAL MEDICINAL DRUGS (T)
HOUR/WEEK :1, ECTS:1
Preparation methods of herbal medicinal drugs (as liquid dosage forms, capsules, tablets,
transdermal formulations, particular dosage forms, compress and bolus), Biopharmaceutical
characterization of herbal medicinal drugs, Standardization of herbal medicinal drugs, Bioavailability
of herbal medicinal drugs, Stability of herbal medicinal drugs, Quality assurance of herbal medicinal
drugs, Dosage forms of herbal medicinal drugs and GMP.
(ECZ729) BASIC PHARMACEUTICAL PROCESSES (T)
HOUR/WEEK :1, ECTS:1
Selection of parameters to investigate, depending on the dosage form to be developed. Selection of
parameters to investigate, depending on active agent. Selection of parameters to investigate,
depending on polymer and excipients. Solubility and dissolution rate mechanism and determination
in media and polymer. Determination of diffusion coefficient and its importance in bioavailability.
Determination of partition coefficient and its importance in formulation. Particle size analysis and its
importance in formulation.
(ECZ730) DRUG SAFETY AND RISK ASSESSMENT IN DRUG USE (T)
HOUR/WEEK: 2, ECTS:2
Introduction of drug safety; Role of risk assessment in risk management; Constituting risk
information during clinical trials; Special issues that must be taken into consideration during risk
assessment; Pre-clinic and clinic studies before approval stage of drug; Adverse drug reactions (ADRs)
and pharmacovigilance; Importance of pharmacovigilance and ADR monitoring centers; Importance
of adverse drug reactions (ADR) in terms of patient harm and deaths; Post-marketing monitoring and
reports of ADR; Withdrawal of drugs from market due to toxic effects; Classification of adverse drug
effects and type A adverse reactions; Type B adverse reactions: Idiosyncratic reactions and
underlying factors; ADRs not dependent to dose; Hypersensitivity; Allergy; Allergic drug reactions,
anaphylaxis and serious dermal reactions; Photoallergy; Hepatotoxicity and blood discrasies;
Induction and inhibition; Safety of vegetal drugs; Adverse effects due to genetic polymorphism in
drug metabolizing enzymes; Polymorphism of Cytochrome P450 (CYP) and Phase II enzymes; Drug
safety in future
(ECZ731) GENETIC FACTORS IN EFFICIENT DRUG USE (T)
HOUR/WEEK:1, ECTS:1
Role of interindividual genetic differences in drug use; Mechanisms of interindividual genetic
differences in drug use; The toxicity originated from interindividual genetic differences in drug use;