For healthy potatoes - Bayer CropScience

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Azoles inhibit fungal sterol synthesis Azoles are organic chemical compounds containing a five-membered ring structure, including at least one nitrogen atom. If the ring contains three nitrogen atoms and two carbon atoms, one speaks of a triazole. In the strictest sense, triadimefon, triadimenol, tebuconazole and all of the other azole fungicides Bayer has brought onto the market belong to the class of triazoles. Because of their mode of action, azole fungicides are classified as DMIs, sterol demethylation inhibitors. They block fungal biosynthesis of sterols, components of fungal cell membranes that are indispensable for their stability and function. No functional sterols – no intact cell membrane – no fungal growth. Pharmaceutical azoles act on the same principle. The invention of tebuconazole meant a further leap forward in azole development. Like the older azole fungicides, tebuconazole interferes with sterol biosynthesis, but it is active against more fungal pathogens in a greater number of crops than the earlier azoles. Back in August 1981, nobody in the Bayer pharmacology labs anticipated that the substance would eventually take the market by storm. But Bayer had wisely patented tebuconazole in European countries and the USA soon after synthesis. Years of development work followed, now under the aegis of plant protection specialists in Monheim. Finally, in 1988, the time was ripe for market launch: the foliar fungicide Folicur ® made its debut. Tailored products from the Folicur family Folicur started as a fungicide intended mainly for cereals. But, step by step, the product became ever more diversified in terms of formulation, application range and mixtures. Today, it is registered and sold in some 100 countries and applied to more than 90 different crops. Various formulations and mixtures are tailored to the special needs of each crop and country. Whether for tropical fruits such as mango or banana, coffee or tea, vegetables in temperate climates, potatoes, grapes, soybean or oilseed rape – with its extraordinary spectrum of activity, Folicur reliably protects all of these crops against fungal diseases. As indicated by the Folicur slogan “It works. Year after year”, DMI fungicides have been proving their efficacy for 30 years now. To preserve the current spectrum-of-control and the performance of azoles, guidelines on Resistance Management should be followed. One tool for proactively managing resistance is the alternation or combination of DMIs with fungicides from other classes of active ingredients with different modes of action. For example, the product Nativo ® combines tebuconazole with the strobilurine fungicide trifloxystrobin, which acts as a respiration inhibitor in the pathogen. Many other Bayer CropScience products containing tebuconazole in mixture with other fungicides that inhibit different targets are sold around the world. To name only a few, examples include Folicur Multi, Falcon ® , Teldor ® combi and Pronto ® Plus. As this huge product range only accounts for foliar fungicides. At the same time, tebuconazole is being used very successfully in seed treatment. In the early 1990s, Bayer introduced these products under the brand of Raxil ® . Today, Raxil is sold in some 50 countries around the globe for the control of all of the major soil- and seed-borne diseases of wheat and barley seedlings. In Raxil Ultra, tebuconazole comes at a double concentration; in other seed treatment products, the fungicide is mixed with the blockbuster insecticide imidacloprid. Heavyweights on the fungicide market Whether used as a spray, as a seed treatment or for special applications such as turf protection or as a wood preservative, tebuconazole is still a world-class fungicide – even 25 years after first synthesis. “Folicur and Raxil can be rightly regarded as milestones in fungicide development”, says Horst Stauff, Brand Communication Manager Fungicides with Bayer CropScience in Monheim. “And although nearly twenty years on the market, both products still represent the state of the art”, Stauff adds. With more than 300 million Euro sales in 2005, Folicur is number two in the Bayer CropScience portfolio, surpassed only by the insecticide Confidor ® . “The massive occurrence of Asian soybean rust in Brazil gave Folicur another boost quite recently”, explains Karin Wieczorek, Product Manager Fungicides. Taking the share of the world fungicide market as a marker of success, Bayer Crop- Science scores very well. Tebuconazole is one of the world’s best-selling triazoles. These days, triazoles constitute the most important group of fungicides, accounting for around 25 percent of the world market. Bayer CropScience is highly engaged in this market, and has constantly been launching new azoles. After the success of 4 COURIER 2/06
Countries in which tebuconazole-containing products are registered for use in a wide range of crops. Bayleton and Baytan, the company introduced bitertanol, sold as the foliar fungicide Baycor ® for use in fruit, vegetables and flowers or as Sibutol ® for seed treatment in wheat. Tebuconazole was followed by the development of several other triazoles, e.g. fluquinconazole, the basis for products such as Flamenco ® , Palisade ® and Galmano ® . The success story goes on The track record of triazole fungicides made by Bayer CropScience has certainly not come to an end yet: the latest development, leading to the new chemical class of triazolinthiones, is called prothioconazole. This new molecule has an extremely broad spectrum of activity. A wide application window, rapid uptake of the active substance by the plant, good rainfastness and long-lasting activity combine to create a new dimension in the effective control of plant diseases. Since 2004, the substance has been sold in several countries under the trade name Proline ® , a spray fungicide, and Redigo ® , a seed treatment product. Prothioconazole was first approved in Germany under the trademark Proline for spray application and rapidly secured a large market share there. Since then, users in a further 16 countries have become convinced by the outstanding protective and curative activity of the product. Bayer CropScience received marketing authorization for prothioconazole in France in mid- 2006. Fandango ® , a combination of prothioconazole with the strobilurin fungicide fluoxastrobin, has been launched in some European countries and is already wellestablished, particularly in barley. In 2005, the prothioconazole-containing seed treatment product Redigo was first launched in the UK. It is an easy-tohandle formulation and meets all of the requirements and safety standards expected of a modern crop protection product. Scenic ® combines prothioconazole, fluoxastrobin and tebuconazole, and was primarily created for the premium market in Europe. Lamardor ® is a new highly-concentrated formulation containing prothioconazole and tebuconazole that has been developed especially for Central and Eastern Europe. Increasing spectrum-of-use Although already a leader in triazoles, Bayer CropScience is committed to further improving its fungicides. For new challenges arising in farming can always call for new solutions. For instance, Fusarium spp. has only relatively recently gained significant importance in cereals. Fusarium diseases reduce both harvest quantity and the quality of grains; but most importantly, several Fusarium species are capable of producing dangerous mycotoxins that can affect human and animal health. For optimal control of Fusarium diseases, Bayer CropScience has developed Prosaro ® , a combination of the recentlydeveloped prothioconazole with the wellestablished tebuconazole. The rapid initial efficacy of tebuconazole, along with the long-lasting efficacy of prothioconazole, leads to a convincing solution against Fusarium. So what is the conclusion Tebuconazole works, year after year, even after 25 years. ■ 2/06 CORREO 5
Page 1 and 2: COURIER The Bayer CropScience Magaz
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Page 9 and 10: Extreme stress: many plants suffer
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Page 17 and 18: Hugely successful in corn, the use
Page 19 and 20: The Strengths of Arize Hybrid Rice
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Page 23 and 24: pests are controlled, whilst their
Page 25 and 26: future Globally farming faces giant
Page 27 and 28: A soil structure with the optimum s
Page 29 and 30: Fusarium ear blight Snow mould in w
Page 31 and 32: ment. This can only occur if the re

For healthy potatoes - Bayer CropScience

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