Dr Ashwini Mital - Uckkr.org

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Research projects (Collaborative work; 2007 – 2009) 1. Role of cytokines in skeletal muscule Atrophy (NIH funded, USA) Tumor Necrosis Factor-related Weak Inducer of Apoptosis is a potent muscle-wasting cytokine which induces atrophy in cultured skeletal muscle cells. Worked as a Postdoc fellow 2. Specific adrenergic receptors and PKC/ERKs isoforms in cerebral arterial contraction and their role in cerebral blood flow (NIH funded, USA) – Worked as a Postdoc fellow Other Research Contributions (2005-2007) Study of Dipeptidylaminopeptidases/ cathepsins/ xylanase enzymes by using different sources i.e. plants; microbial and animal brain for the purpose of its purification, enzyme kinetics and inhibition studies. Inhibition kinetics with some anti-tuberculous, anti-inflammatory and anti-leprotic drugs on cathepsins. “Immobilization of DPP IV and its application in Bio-transformation” (UGC funded Project, Delhi-India, 2006-2007). Current Research Project: (2012 – 2015) Effect of S-allyl cysteine on inflammatory and oxidative response in skeletal muscle metabolism (Funded by UGC, New Delhi, India – Rs 15 lacs) Representative publications Published Papers (http://www.refdoc.fr/NoticeresultatNoticeresultat2nbPageP=1 ) THE REFERENCE IN SCIENTIFIC DOCUMENT SUPPLY (refdoc) (http://www.ncbi.nlm.nih.gov/pubmed) Bhatnagar S*, Mittal A* (first author), Gupta SK, Kumar A. TWEAK causes myotube atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases. J Cell Physiol. 2012, 227(3).1042-51. PMID: 21567392. Aggarwal R, Sumran G, Kumar V, Mittal A. Copper(II) chloride mediated synthesis and DNA photocleavage activity of 1-aryl/heteroaryl-4-substituted-1,2,4-triazolo[4,3-a]quinoxalines. Eur J Med Chem. 2011, 46(12), 6083-8. PMID: 22051064 Mittal A, Mandal TK, Bindal R and Dabur R. Cathepsin B is a negative regulator in pulmonary aspergillosis. IJBBB, 2011, 1(2): 125-130. Mittal A, Bhatnagar S, Kumar A, Paul PK, Kuang S and Kumar A. Genetic Ablation of TWEAK Augments Regeneration and Post-Injury Growth of Skeletal Muscle in Mice. American Journal of Pathology. 2010, Aug 19. [Epub ahead of print], PMID: 20724600 Mittal A, Bhatnagar S, Kumar A, Lach-Trifilieff E, Wauters S, Li H, Makonchuk DY, Glass DJ, Kumar A. The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice. J Cell Biol. 2010 Mar 22;188(6):833-49. PMID: 20308426. Goyal R, Mittal A, Chu N, Arthur RA, Zhang L, Longo LD. Maturation and Long-Term Hypoxia-
Induced Acclimatization Responses in PKC-Mediated Signaling Pathways in Ovine Cerebral Arterial Contractility. Am J Physiol Regul Integr Comp Physiol. 2010 Aug 11. [Epub ahead of print] PMID: 20702800. Goyal R, Mittal A, Chu N, Zhang L, Longo LD. Alpha(1)-Adrenergic receptor subtype function in fetal and adult cerebral arteries. Am J Physiol Heart Circ Physiol. 2010, 298(6):H1797-806. PMID: 20348219. Gheorghe CP, Goyal R, Mittal A, Longo LD. Gene expression in the placenta: maternal stress and epigenetic responses. Int J Dev Biol. 2010; 54(2-3):507-23. Review. PMID: 19876832. Sanghi A, Garg N, Gupta VK, Mittal, A, Kuhad RC. One-step Purification and Characterization of cellulase-free Xylanase Produced by Alkalophilic Bacillus Subtilis Ash. Brazilian Journal of Microbiology, 2010, 41(2), 467-476. Li H, Mittal A, Makonchuk DY, Bhatnagar S, Kumar A. Matrix Metalloproteinase-9 Inhibition Ameliorates Pathogenesis and Improves Skeletal Muscle Regeneration in Muscular Dystrophy. Hum Mol Genet. 2009 Apr 28. PMID: 19401296 Li H, Mittal A, Paul PK, Kumar M, Srivastava DS, Tyagi SC, and Kumar A. Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase-9 production (MMP- 9) in skeletal muscle through the activation of nuclear factor-kappa B-inducing kinase and p38 mitogen-activated protein kinase: A potential role of MMP-9 in myopathy. J Biol Chem. 2009 284(7):4439-50. PMID: 19074147 Goyal R, Mittal A, Chu N, Shi L, Zhang L, Longo LD. Maturation and the role of PKC-mediated contractility in ovine cerebral arteries. Am J Physiol Heart Circ Physiol. 2009, 11. [Epub ahead of print] PMID: 19749163 Goyal R, Galffy A, Field SA, Gheorghe CP, Mittal A, Longo LD. Maternal protein deprivation: changes in systemic renin-angiotensin system of the mouse fetus. Reprod Sci. 2009 16(9): 894- 904. PMID: 19516079 Kumar M, Makonchuk DY, Li H, Mittal A, and Kumar A. Tumor Necrosis Factor-like Weak Inducer of Apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta activating kinase 1. J Immunol. 2009; 182(4):2439- 48. PMID: 19201899. Sharma S, Mittal A, Gupta VK and Singh H. 2007. "Improved stabilization of microencapsulated Cathepsin B in harsh conditions" Enz Microb Tech, 40, 337-342. Sharma S, Mittal A, Gupta VK and Singh H. 2006. "Stabilization of immobilized Cathepsin L in Non-aqueous medium". Biocatalysis and Biotransformation, 18(2), 1-7. Sharma J, Singh A, Mittal A, Kumar A. 2006. Partial purification of an alkaline protease from a new strain of Aspergillus oryzae AWT 20 and its enhanced stabilization in entrapped Ca-alginate beads. Internet J Microbiology, 2(2). Mittal A, Singh H and Kamboj RC. 2005 "Characterization of Dipeptidyl Peptidase IV (DPP IV) in Ca-alginate beads. Enz Microb Tech, 37, 318-323. Sadana R, Mittal A, Khurana S, Singh H and Kamboj R C. 2003. Purification and characterization of cathepsin L-Iike from goat brain. Ind. J Biochem. Biophys. 40, 315-323 Kamboj RC, Raghav N, Mittal A, Khurana S, Sadana R and Singh H. 2003. Effects of Some Antituberculous and AntiLeprotic Drugs on Cathepsins B, H and L. Ind. J. Clin. Biochem.18 (2),39-47.
Page 1: Ashwani Mittal, M.Sc. Ph.D (Protein
Page 5 and 6: Li H, Mittal A, Makonchuk DY, Bhatn
Page 7: ‣ 88 th Indian Science Congress A

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