PART 5_2 Chemical contaminants and ecotoxicology
PART 5_2 Chemical contaminants and ecotoxicology
PART 5_2 Chemical contaminants and ecotoxicology
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Protective biochemical response<br />
PHASE 1 REACTION.<br />
• Organic pollutants could also be metabolized <strong>and</strong><br />
detoxified by Cytochrome P450 enzymes<br />
(Microsomal Monoxygenase; MMO).<br />
PHASE 2 REACTION<br />
• The metabolites undergo conjugation with<br />
endogenous molecules e.g. GSH.<br />
• For some chemicals the metabolites/conjugated<br />
form are more toxic than the parent compound <strong>and</strong><br />
can lead to cancer formation.
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