PART 5_2 Chemical contaminants and ecotoxicology
PART 5_2 Chemical contaminants and ecotoxicology
PART 5_2 Chemical contaminants and ecotoxicology
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3. Biomarkers of Susceptibility<br />
Biomarkers of susceptibility indicate individual factors<br />
that can affect response to an environmental toxicant<br />
(Bearer, 1998). They are indicators of inherent or<br />
acquired properties of an organism that may lead to an<br />
increase or decrease in the internal dose of the<br />
xenobiotic or an increased or decreased level of the<br />
response resulting from the exposure.<br />
Genetic polymorphisms fall into this category of<br />
biomarkers.<br />
P450 1A1 induction<br />
Decreases in conjugated enzymes<br />
Inhibit the activity of immune system