Fall/Winter 2006 - University of Rochester Medical Center

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“The University of Rochester and the School of Medicine increasingly will be known as one of the places for conducting translational research and for training successful academic researchers.” David Guzick, M.D., Ph.D. U.S. Senator Charles E. Schumer, a New York Democrat, saluted the School of Medicine and Dentistry. “When the National Institutes of Health scoured the nation for the best universities to improve medical care, they made a bee-line to Rochester,” Schumer said. “We are blessed to have world-class medical research facilities here at the University of Rochester, and this grant rightfully recognizes Rochester as a national leader in clinical research. Through this program, the University of Rochester will remain at the cutting edge of health care improvements and innovations.” U.S. Rep. James T. Walsh, a Republican whose district stretches from the Rochester area to Syracuse, said: “ This is fantastic news for the University of Rochester and will energize the scientific research community throughout Central New York. This announcement ensures that the University of Rochester will continue to be at the forefront of new scientific advances that will dramatically improve the quality of our medical care for generations to come.” A new type of scientist NIH defines clinical research as studies and trials that involve human subjects. Translational research includes the process of applying discoveries made in the laboratory, testing them in animals, and developing trials and studies for humans and research that enhances the adoption of best treatment practices in the medical community. Clinical and translational studies are being hampered by increases in costs and complexity, a dearth of information systems, and increases in the regulatory burden, Zerhouni has said. “An explosion in clinical-service demands and reduced financial margins have sharply cut protected research time for many clinical and translational researchers and diluted the time and attention devoted to the research mission of academic institutions,” he wrote in The New England Journal of Medicine. “The inevitable result of these changes has been, for example, difficulties in the recruitment and retention of human subjects in clinical trials and, ultimately, considerable delay in the completion of critical studies.” The complex resources needed to conduct modern clinical and translational research are either missing or scattered, Zerhouni said. Bioinformatics, bench-to-bedside laboratories, and statistical cores are not integrated in an efficient way. Researchers increasingly target chronic disease, whose treatment consumes about 75 percent of the nation’s health care resources, and this requires more research on human populations. “Today, there is good reason to believe that the scope of knowledge and expertise needed to be an effective translational or clinical scientist can no longer be acquired on the job, as was done in the past,” Zerhouni said. Thomas Pearson, M.D., M.P.H., Ph.D., co-director of Rochester’s new Institute and senior associate dean for clinical research and chair of the Department of Community and 6 ROCHESTER MEDICINE
Left: Press conference announcing largest NIH gift ever to the University with University President Joel Seligman, Bradford C. Berk, M.D., Ph.D., David Guzick, M.D., Ph.D., and Thomas Pearson, M.D., M.P.H., Ph.D. Right: Thomas Pearson, M.D., M.P.H., Ph.D., and David Guzick, M.D., Ph.D., will lead the new Institute. Preventive Medicine, says translational research “requires a new type of scientist —a scientist with a solid knowledge of basic bench sciences and the skills to apply the discoveries of science to the health care needs of people. Such researchers are in short supply.” The School of Medicine will designate a significant part of the NIH award for the education and training of physicians and researchers. The new Institute will sponsor programs to educate translational researchers at a variety of levels. Three new graduate degrees will be offered: Master of Science in Clinical Investigation, Master of Science in Translational Research and Doctor of Translational Biomedical Research. The education and training programs, which begin in medical school, will foster multidisciplinary research and collaboration. A new program will support scientists in the beginning of their faculty careers so they can concentrate on translational research. The coursework will expand clinical knowledge. An extra year of laboratory experience will enhance skills. Regional dynamo Under Pearson’s leadership, the School of Medicine also will organize a consortium known as the Upstate New York Translational Research Network. In addition to the School of Medicine, the proposed members are: State University of New York (SUNY) at Buffalo, SUNY Upstate Medical University in Syracuse, SUNY Binghamton, Cornell University Division of Nutritional Sciences, Ordway Research Institute, Albany Medical College, Albany College of Pharmacy, Bassett Healthcare System in Cooperstown, and Guthrie Healthcare System in Sayre, Pa. The Upstate Network will give members a way to share expensive sophisticated research technologies. It will provide a vehicle for training scientists from member institutions for clinical and translational sciences, again addressing the shortage in this field. The Network also will vastly expand the area for recruitment of people to participate in clinical trials while the Institute will provide expertise to all members in the regulation and ethics of conducting trials. “The Network will promote collaboration among scientists from member institutions and across disciplines — the kind of interaction that does not occur frequently enough, yet is conducive to Continued on page 68 In addition to Rochester’s School of Medicine and Dentistry, the initial award recipients in the National Institute of Health’s translational science initiative are: Columbia University Health Sciences, Duke University, Mayo Clinic College of Medicine, Oregon Health and Science University, Rockefeller University, University of California at Davis, University of California at San Francisco, University of Pennsylvania, University of Pittsburgh, University of Texas Health Science Center at Houston and Yale University. FALL / WINTER 2006 7
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Fall/Winter 2006 - University of Rochester Medical Center

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