28.01.2015 Views

Prioritizing new malaria vaccine candidates for further development

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<strong>Prioritizing</strong> through defining/managing uncertainty:<br />

controlled human <strong>malaria</strong> infections<br />

Experimental medicine<br />

Translational<br />

research<br />

Challenge<br />

model(s)<br />

Product <strong>development</strong><br />

Translational<br />

<strong>development</strong><br />

Challenge<br />

model(s)<br />

Phase1<br />

Control<br />

Vaccine 1<br />

Vaccine 2<br />

Infected mosquitoes<br />

Aseptic sporozoites<br />

Blood-stage parasites<br />

Time after challenge<br />

27

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