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Prioritizing new malaria vaccine candidates for further development

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Sources and management of uncertainty and risk<br />

in <strong>vaccine</strong> <strong>development</strong> (PTRS)<br />

Strategic<br />

goal<br />

Biological<br />

Immunity<br />

Malaria <strong>vaccine</strong>s<br />

Safety/<br />

Tolerability<br />

Technical (R&D)<br />

CMC Clinical Regulatory<br />

Uncertainty --- --- Uncertainty Uncertainty<br />

Vaccine Uncertainty Uncertainty Both Risk Both<br />

<strong>Prioritizing</strong> through<br />

defining/managing<br />

uncertainty<br />

26

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