Sodium Pantothenate

Sodium Pantothenate
C9H16NNaO5 Mol. Wt. 241.2
monosodium (R)-N-(2,4-dihydroxy-3,3-dimethylbutyl)-3-aminopropanoate75033-16-8
Content Sodium Pantothenate, when calculated on the dried basis, contains 5.6
6.0% of nitrogen (N=14.01) and 9.39.7% of sodium (Na=22.99).
Description Sodium Pantothenate occurs as a white powder. It is odorless and
has a slightly acid taste.
Identification (1) Proceed as directed under Identification (1) and (2) for
Calcium Pantothenate.
(2) Sodium Pantothenate solution (1 20) responds to all tests for Sodium Salt
as described in the Qualitative Tests.
α : +25.05 +28.5 (previously dried, 1.25 g,
Purity (1) Specific rotation [ ] 20
D
water, 25 ml).
(2) pH 9.010.0.
Weigh 2.0 g of Sodium Pantothenate, add water to make 10 ml, and measure.
(3) Calcium Weigh 1.0 g of Sodium Pantothenate, dissolve in 10 ml of water,
and add 0.5 ml of diluted acetic acid (1 20) and 0.5 ml of ammonium oxalate
solution (1 25). No precipitate is formed.
(4) Heavy metals Not more than 20µg/g as Pb (1.0 g, Method 1, Control
solution Lead Standard Solution 2.0 ml).
(5) Arsenic Not more than 4.0µg/g as As2O3 (0.50 g, Method 1, Apparatus B).
(6) Alkaloid Proceed as directed under Purity (5) for Calcium Pantothenate.
Loss on Drying Not more than 5.0% (reduced pressure, 24 hours).
Assay (1) Nitrogen Weigh accurately about 50 mg of Sodium Pantothenate,
proceed as directed under the Semi-micro Kjeldahl Method in Nitrogen Determination,
and calculate on the dried basis.
(2) Sodium Weigh accurately about 0.6 g of Sodium Pantothenate, dissolve in 50
ml of acetic acid, and titrate with 0.1 mol/l perchloric acid (indicator: 1 ml of crystal
violetacetic acid TS) until the color of the solution changes from purple through blue
to green. Perform a blank test in the same manner, make any necessary correction,
and calculate on the dried basis.

1 ml of 0.1 mol/l perchloric acid = 2.2990 mg of Na