Current issues in Hereditary Angioedema (HAE) - Ipopi
Current issues in Hereditary Angioedema (HAE) - Ipopi Current issues in Hereditary Angioedema (HAE) - Ipopi
Icatibant (Firazyr) • Subcutaneous bradykinin inhibitor – Local pain & swelling ‘giant bee-sting’ – Almost anyone can learn – Risks: large swelling, patient with frequent attacks • Ideal for self administration • Speed of onset of relief and resolution broadly equivalent to C1 inhibitor t=0 min t=30 min
Icatibant (Firazyr) • Recurrent attacks – Usually slow onset – May occasionally be fast – 10% need retreatment • Risk of recurrence increased if: – Large swelling/severe attack – Late in course of attack – Very frequent attacks (>1/week) Always have second syringe available- will be effective
- Page 1 and 2: Current issues in Hereditary Angioe
- Page 3 and 4: What is HAE (Hereditary • HAE 1 o
- Page 5 and 6: C1 inhibitor controls inflammation
- Page 7 and 8: What have we learnt about the new
- Page 9 and 10: • Berinert (C1 inhibitor) trials
- Page 11: Treatment of C1 inhibitor deficienc
- Page 15 and 16: Living with hereditary angioedema:
- Page 17 and 18: L’s story: 25 year old with HAE
- Page 19 and 20: L’s story •15 th March 2010- 2
- Page 21 and 22: Treatment of C1 inhibitor deficienc
- Page 23 and 24: Self administration C1 ınhıbıtor
- Page 25 and 26: C1 inhibitor controls local Healthy
- Page 27: Rational use of steroids….
- Page 30 and 31: Mr B 15 years • Unwilling to trai
- Page 32 and 33: Mrs B 42 years • Danazol 100 mg a
- Page 34 and 35: Need to control acute attacks
- Page 36 and 37: What does everyone want • Patient
- Page 38: Recent initiatives • World consen
Icatibant (Firazyr)<br />
• Recurrent attacks<br />
– Usually slow onset<br />
– May occasionally be fast<br />
– 10% need retreatment<br />
• Risk of recurrence <strong>in</strong>creased if:<br />
– Large swell<strong>in</strong>g/severe attack<br />
– Late <strong>in</strong> course of attack<br />
– Very frequent attacks (>1/week)<br />
Always have second syr<strong>in</strong>ge available- will be effective
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