Mondobiotech Holding AG Company presentation

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Scientific Snapshot Information: DK-0112-01 §� Sarcoidosis is a systemic, chronic, inflammatory, granulomatous disease of unknown origin, primarily affecting the lungs but it can affect almost all organs of the body, including the skin. It is often followed by, progressive fibrosis, leading to a need for transplantation. Sarcoid Lung §� Mechanism of Action: Healthy Lung DK-0112 is synthetically produced 5 amino acid peptide. It acts via binding to MHC class II molecules present on T cells and NK cells, increasing NK cell activity and regulating T cell growth and differentiation. §� Key data (in vivo human PoC data): Clinical PoC has been demonstrated in cutaneous sarcoidosis, atopic dermatitis, and rheumatoid arthritis. DK-0112 also reduced itching, oedema, scaling and thickening, and clearing of erythroderma and cell infiltrates in patients with Sézary syndrome (cutaneous Tcell lymphoma). Before after DK-0112 Before after DK-0112 Sézary syndrome 48
Scientific Snapshot Information: DK-0014-01 §� HCC is a liver cancer with a high mortality and morbidity rate. This type of cancer is mainly caused by Hepatitis B Virus (HBV) or Hepatitis C Virus (HCV) infection - insults that cause long-term inflammation, fibrosis and cirrhosis of the liver - and alcohol abuse. §� Mechanism of Action: Synthetically produced 36 amino acid peptide, Cterminally amidated. It acts via activating 5 different G protein-coupled receptors, which are expressed in the brain, heart, gut, liver, kidney and blood vessels. These receptors signal through the GTP binding proteins Gi/Go, inhibiting gastric acid secretion, small bowel and colonic chloride secretion, and pancreatic insulin secretion. §� Key data (in vivo animal model data): DK-0014 inhibits growth of hepatomas in nude mice -ve control DK-0014 49
Page 1 and 2: Mondobiotech Holding AG Company pre
Page 3 and 4: mondoBIOTECH at a glance • Headqu
Page 5 and 6: Board of Directors Robert Edward Pa
Page 7 and 8: Our approach to drug discovery •
Page 9 and 10: Introduction to the Search&Match me
Page 11 and 12: The Model • Knowledge from litera
Page 13 and 14: The Search and Match Software Platf
Page 15 and 16: Match • Any path through the know
Page 17 and 18: Match - a multi-technique approach
Page 19 and 20: Bio-Mathematical Technology Platfor
Page 21 and 22: Match - Project DK-0112-01 21
Page 23 and 24: Match - Project DK-1001-01 23
Page 25 and 26: MPC Validation: the mondoBIOTECH Co
Page 27 and 28: Set up of new projects PROJECT SET
Page 29 and 30: Intellectual Property Strategy & Cu
Page 31 and 32: mondoBIOTECH’s IP Strategy Two in
Page 33 and 34: mondoBIOTECH’s IP Strategy: Two I
Page 35 and 36: Orphan Drug Designations 10 Granted
Page 37 and 38: Why Peptides Peptides characteristi
Page 40 and 41: Diversifying the Risk in Drug Disco
Page 42 and 43: Current Pipeline DasKloster 1000-01
Page 46: Scientific Snapshot Information: DK
Page 51 and 52: Products licensed DasKloster 1001-0
Page 53 and 54: Licensed Products • Aviptadil pla
Page 55: mondoBIOTECH holding AG DasKloster

Mondobiotech Holding AG Company presentation

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