Mondobiotech Holding AG Company presentation
Mondobiotech Holding AG Company presentation
Mondobiotech Holding AG Company presentation
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Scientific Snapshot Information: DK-0112-01<br />
§� Sarcoidosis is a systemic, chronic, inflammatory,<br />
granulomatous disease of unknown origin, primarily<br />
affecting the lungs but it can affect almost all organs of<br />
the body, including the skin. It is often followed by,<br />
progressive fibrosis, leading to a need for transplantation.<br />
Sarcoid Lung<br />
§� Mechanism of Action:<br />
Healthy Lung<br />
DK-0112 is synthetically produced 5 amino acid peptide.<br />
It acts via binding to MHC class II molecules present on T<br />
cells and NK cells, increasing NK cell activity and<br />
regulating T cell growth and differentiation.<br />
§� Key data (in vivo human PoC data):<br />
Clinical PoC has been demonstrated in cutaneous<br />
sarcoidosis, atopic dermatitis, and rheumatoid arthritis.<br />
DK-0112 also reduced itching, oedema, scaling and<br />
thickening, and clearing of erythroderma and cell<br />
infiltrates in patients with Sézary syndrome (cutaneous Tcell<br />
lymphoma).<br />
Before after DK-0112<br />
Before after DK-0112 Sézary syndrome<br />
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