to view the CV - Saudi Arabian Cultural Mission

CURRICULUM VITAE 

UNIVERSITY OF TOLEDO COLLEGE OF MEDICINE 

PERSONAL INFORMATION: 

Ragheb A. Assaly, M.D. 

Business Address: 

Home Address: 

3000 Arlington Avenue 6710 Victoria Court 

Toledo, Ohio 43614 Sylvania, OH 43560 

Telephone: 419 383 3543 Telephone: 419 824 7394 

Fax: 419 383 6243 

Email: ragheb.assaly@utoledo.edu 

Spouse: 

Rana 

Children: Akram, Ahmad, Omar 

DOB: 2/13/1959 

Place of Birth: Jerusalem 

EDUCATION AND TRAINING: 

M.D. Medicine & Surgery, University of Romania, Cluj-Napoca; 9/1977 - 9/1984 

POST GRADUATE MEDICAL EDUCATION, FELLOWSHIP: 

1984 -1985 Augusta Victoria Hospital, P.O. Box 19178, East Jerusalem, Rotating Internship 

1985 -1987 Augusta Victoria Hospital, P.O. Box 19178, East Jerusalem, Internal Medicine 

Resident 

1987-1991 Makassed Hospital, P. O. Box 19482, Mount of Olives, East Jerusalem 

Senior Resident and Chief Resident Internal Medicine, Completed requirement 

for Jordanian Board in Internal Medicine 

1990 -1991 Case Western University, 11100 Euclid, Cleveland, Ohio, United States, 

Echocardiography training (three months). 

1991 -1992 Makassed Hospital, P. O. Box 19482, Mount of Olives, Jerusalem, Educational 

Coordinator

1992 -1993 D. C. General Hospital, 19 th & Massachusetts Ave SE, Washington, D. C., United 

States. Internship in Internal Medicine 

1993 -1995 Grady Memorial Hospital, Morehouse School of Medicine, 720 Westview Dr. SW, 

Atlanta, GA. United States, Resident in Internal Medicine 

1995 -1998 Medical College of Ohio, 3000 Arlington Ave, Toledo, Ohio, United States, 

Fellowship in Pulmonary/Critical Care Medicine. 

1999 -2000 Medical College of Ohio, 3000 Arlington Ave, Toledo, Ohio, United States 

Teaching Scholars Fellowship 

2005 - 2006 University of Toledo, 3000 Arlington Ave, Toledo, Ohio, United States 

Fellowship in Sleep Disorders, Sylvania Regional Sleep Center 

2008 University of Toledo, 3000 Arlington Ave, Toledo, Ohio, United States 

Transformation Leadership Graduate Certificate 

2009 - 2010 University of Toledo, 3000 Arlington Ave, Toledo, Ohio, United States 

Biostatistics and Clinical Research Graduate Certificate 

EMPLOYMENT: 

1998 - 2004 Assistant Professor, Pulmonary/Critical Care Division, Medical University 

of Ohio, Toledo, OH 

2004 – 2008 Associate Professor, Pulmonary/Critical Care Division, University of 

Toledo, Toledo, OH 

2000 - Present Director, Medical Intensive Care Unit, University of Toledo, Toledo, OH 

2002 - 2007 Associate Program Director, Internal Medicine Residency Program, 

University of Toledo College of Medicine 

2007 - Present Program Director, Internal Medicine Residency Program, University of 

Toledo College of Medicine 

2008 - Present Professor, University of Toledo College of Medicine 

2011 -Present Chairman –Clinical Advisory Board for ADS Biotechnology. 

CERTIFICATIONS/LICENSURES: 

1991 Medicine, National Board of Medical Examiners (ECFMG). 

Certification Number: #4037198 

1995 Internal Medicine, American Board of Internal Medicine. 

Certification Number: 164096 

1995 Managed Care Program, Harvard Community Health Plan. 

Certification Number: N/A 

1996 Advanced Cardiac Life Support Provider, American Heart Association. 


1996 Advanced Cardiac Life Support Instructor, American Heart Association. 


1996 Advanced Trauma Life Support, American College of Surgeons. 


1996 Clinical Hyperbaric Medicine, American College of Surgeons. 


1996 Ohio State Medical License, State Medical Board of Ohio, 

Certification #: 35071674-A (Active). 

1997 Pulmonary Medicine, American Board of Internal Medicine. 

Certification #: 164096 

2

1999 Teaching Scholars Fellowship. Medical University of Ohio 

2000 Controlled Substances Registration Certificate (DEA) United States Department of 

Justice, Drug Enforcement Administration, Certification #: BA5558688 

2003 Fellow of the American College of Chest physicians (FACCP) 

2006 American Board of Internal Medicine 

Board Certified in Critical Care Medicine 2006-2016. 

2006 American Board of Sleep Medicine - Board certified (no time limit) 

Diplomat, American Board of Sleep Medicine (DABSM) 

2007 American Board of Internal Medicine. 

Internal Medicine 2007-2017. – Recertification. 

2007 American Board of Internal Medicine 

Pulmonary Diseases 2007-2017. –recertification. 

2008 Transformational Leadership Graduate Certificate, University of Toledo 

2010 Biostatistics and Clinical Research Graduate Certificate University of Toledo 

MILITARY SERVICE: 

N/A 

PROFESSIONAL SOCIETIES: 

1985 - Present Member, Jordanian Medical Council 

1996 – Present Member, American College of Physicians (ACP) 

1997 – 2003 Associate, American College of Chest Physicians (ACCP) 

2003 - Present Fellow, American College of Chest Physicians (FACCP) 

1997 - Present Associate, American Thoracic Society (ATS) 

1994 – 1995 Southern Medical Association 

1999 - Present American Society of Critical Care Medicine 

1997 - Present Ohio Thoracic Society 

1999 - Present National Arab American Medical Association 

2004 – 2006 American Physiological Society 

2006 – Present Member, American Academy of Sleep Medicine 

2006- Present Member, the Alliance for Academic Internal Medicine (AAIM) 

Member, Association of Program Directors in Internal 

Medicine (APDIM). 

AWARDS AND COMMENDATIONS: 

1982, 1983, and 1984. Academic Achievement Award, Medical School, Cluj-Napoca, 

1995. Letter of Achievement. Representation of Georgia Team (winning 

First place) in Medical Jeopardy / Internal Medicine / Southern States 

3

Competition; American College of Physicians (ACP), Atlanta, GA 

1998 Best Case Report, American Thoracic Society / European 

Respiratory Society, Toronto, Canada, 

1999- 2000 Faculty Teaching Award. Internal Medicine Department, Medical 

University of Ohio 

1999 Alfred Soffer Research Award. American College of Chest 

Physicians, Chicago, IL, 

2000 Extraordinary Abilities US Visa (O - Outstanding Visa) – Medical 

University of Ohio, 

2002 National Medical Technology Award (NMTB), Principal Investigator- 

Loma Linda, CA, 2002 

2002 American College of Chest Physician Leadership Program, San 

Diego, CA, 

2004 - 2005. Faculty Teaching Award. Internal Medicine, Medical University of 

Ohio, 

2006 - 2007. Faculty Teaching Award. Internal Medicine, University of Toledo 

Medical Center, 

2007-2008 H. Donabedian Full-Time Faculty Teaching Award, Internal 

Medicine, University of Toledo College of Medicine, 

2009- 2010 Dean’s Award for Teaching Excellence, University of Toledo College 

Of Medicine, 

PATENTS: 

1. US patent, file 02066: 7,037,895. An albumin-based colloid composition and method of 

use in treating hypovelmia and multi-organ dysfunction 

2. US patent, file 04111: 10/985,798. Albumin-based colloid composition having at least 

One protected thiol region, and methods of use 

3. US patent, file 05097: 11/258,646. An albumin-based colloid composition having at 

least one protected thiol region, methods of making, and methods of use 

4. US patent, file 01043: 60/279,017. The use of polyethylene glycol modified albumin 

(Pega) in shock and other capillary leak conditions 

5. US patent application CIP, filed 10/25/2005, MUO-D2006-041. A method and a marker 

for quantifying multiple organ dysfunction (MODS) in systemic inflammatory response 

conditions. 

6. European patent application, PCT/US06/41432. Polyethylene glycol modified albumin 

with cys-34 preserved as a thiol. 

MENTORING: 

Name: 

Department: 

Fred Houts, Masters Student 

Internal Medicine and Biochemistry 

4

Project: 

Analysis of methoxy-polyethylene glycol-modified albumin 

Degree awarded to student: Masters Degree (to be defended December 14, 2005) 

Current position: PGY 3 Psychiatry resident at Johns Hopkins. 

Name: 

Oliver Abela 

Date: 2005-2006 

Department: Internal Medicine 

Project: 

Polyethylene glycol modified albumin (PEG-Alb) 5000 vs. (PEG-Alb) 

40.000 in capillary leak. 

Current position: Graduate student 

Name: 

Department: 

Project: 

Hadeel Altayib, MD 

Internal Medicine 

Use of methoxy-polyethylene glycol-modified albumin in IL-2 induced 

Capillary leak. 

Date 2011-2012 

Current position: Research Assistant 

Name: 

Department: 

Project: 

Abdullah Alajaji, MD 

Internal Medicine 

Use of methoxy-polyethylene glycol-modified albumin in Hemorrhagic 

Shock. 

Date 2011-2012 

Current position: Research assistant 

JOURNAL PEER REVIEW: 

2011-present 

Editorial Board of World Journal of Experimental Medicine (WJEM) 

. 

2005-present 

Critical Care Medicine Journal of the Society of Critical Care 

Medicine (SCCM) 

2005-present 

Chest Journal of the American College of Chest physicians (ACCP) 

STUDY SECTIONS, REVIEW PANELS: 

American Heart Association 

5

Member, Peer Review Committee 1B - To review grant applications from the areas of 

Cardiovascular Development, Lung, Respiration and Resuscitation, Surgery, Radiology and 

Imaging, Orlando, Florida, April 2005. 

American Heart Association 

Member, Peer Review Committee 1B - To review grant applications from the areas of 

Cardiovascular Development, Lung, Respiration and Resuscitation, Surgery; Radiology and 

Imaging, Orlando, Florida, 2006. 

COMMUNITY SERVICE AND ORGANIZATIONS: 

1996, 1997, 1998 Physicians for Peace, Medical Relief Mission 

2003 CareNet Volunteer Physician Specialty 

1-2 times/year Community Care Clinic Staffing 

2010-2011 

USAID Consultant in Critical Care and Education for Palestinian Health Sector 

Developed for the Palestinian Health Sector Reform and Development Project (Flagship 

Project) a manual prepared to target the Emergency Medicine, Anesthesia, Surgery, Family 

Practice, Internal Medicine residents as well as senior medical students and ICU nurses. Most 

of the policies developed were adapted to the context of local hospitals. 

Introduced evaluation system for residency training based on the six educational competencies 

Assisted in the development of the national residency program. 

COMMITTEES, University of Toledo College of Medicine: 

2001 - 2005 Animal Care Committees (IACUC) 

2003 - Open Endoscopy Committee 

2003 - Open Graduate Medical Education 

2003 - Open Internal Medicine Residency Committee (Chairman) 

2003 - 2007 Infection Control Committee 

2003 - 2006 Governance Committee 

(Advisory Committee to the Council of Deans and Board of Trustees) 

2003 - 2004 Admissions Committee 

2007 - Open Antimicrobial Stewardship Committee 

2008 - Cultural Competence Curriculum Committee 

2009- Pharmacy and Therapeutics committee. 

2010- Simulation advisory committee 

2011- Executive Curriculum Committee 

2011- Clinical Advisory Committee for HEO (CPOE) for Implementation & Adoption 

6

SPECIAL/INVITED PRESENTATIONS AT NATIONAL/INTERNAT’L MEETINGS: 

Assaly, RA 

Health consequences of smoking. Staging and modalities of treatment of lung cancer; Al Najah 

University, West Bank Palestine, Physicians for Peace International Conference, 7/1997 

Assaly, RA 

Staging and modalities of treatment of lung cancer; Al Najah University, West Bank Palestine, 

Physicians for Peace International Conference, 7/1997 

Assaly, RA 

Hypertensive Emergency; Hebron University, West Bank Palestine; Physicians for Peace 

International Conference, 7/1998 

Assaly, RA 

Asthma Management; Hebron University, West Bank Palestine, Physicians for Peace 

International Conference, 7/1998 

Assaly, RA 

Pulmonary Embolism/Diagnosis and Management; Beirzeit University, West Bank Palestine, 

Physicians for Peace International Conference, 7/1999 

Assaly, RA 

Severe Sepsis Multi-organ Dysfunction; Beirzeit University, West Bank Palestine, Physicians 

for Peace International Conference, 7/1999 

June 26 - July 5, 2003 

University of Al-Quds, Jerusalem Medical School 

The following lectures were presented to Internal Medicine Residents and fourth year medical 

school students: 

1. Management of Severe Asthma 

2. Management of Sepsis 

3. Mechanical Ventilation 

4. ABG 

5. Treatment of Shock 

6. Hyponatremia 

7. ARDS 

October 28, 2003 

Lecture: Polyethylene glycol modified albumin in capillary leak conditions 

American College of Chest Physicians (ACCP), Leadership Symposium, Orlando, Florida 

November 2003 

Name of Activity: Respiratory Care Symposium, Medical College of Ohio, Toledo, OH, Dana 

Center 

Presenter: RA Assaly 

7

November 1998 

November 2000 

Health Consequences of Smoking 

Pulmonary Hypertension, Assaly RA 

September 3, 2004 

Invited lecturer: Pathophysiology of capillary leak in sepsis 

Ohio Thoracic Society, Cambridge, Ohio 

July 1 - July 5, 2005 

Al-Quds University / Makassed Hospital, Jerusalem, Israel 

Jerusalem Medical School 

The following lectures were presented to Internal Medicine Residents and Senior year medical 

school students: 

1. Sepsis and multi-organ dysfunction syndrome 

2. Pulmonary embolism 

3. Shock-treatment 

4. Morning report discussions 

CONSULTATIVE ACTIVITIES: 

N/A 

MAJOR RESEARCH INTERESTS: 

Sepsis – New modalities of treatment 

Shock pathophysiology 

Endothelial cell function 

Colloids resuscitation 

PAST RESEARCH SUPPORT, TRAINING GRANTS: 

A Randomized Double-blind, Placebo-Controlled Study to Determine the Efficacy and Safety of 

Epoetin Alfa in Critically Ill Subjects; Johnson & Johnson Pharmaceutical Services, 

LLC/Johnson & Johnson 

12/17/2003 – 12/16/2004 

$91,770.00 

Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo 

Ragheb Assaly, M.D. – Co-Investigator 

Efficacy and Safety of Drotrecogin Alfa (activated) in Adult Patients with Early Stage Severe 

Sepsis; Lilly Research Laboratories/Eli Lilly and Company 

8/20/2003 – 9/13/2004 

$41,675.00 



8

A Comparison of the Efficacy, Safety and Pharmacokinetics of the Current US Version of 

Pulmicort Turbuhaler and the New Versus; AstraZeneca, L.P 

1/1/2003 – 10/15/2004 

$65,625.00 



A Phase 3 Comparative Efficacy Study of 5 Days of Clarithromycin Extended Release Tablets 

to 7 Days of Clarithromycin Immed; Abbott Laboratories 

12/3/2002 – 6/3/2004 

$15,990.00 



An 18-week Randomized Double-blind, Placebo-controlled, Multi-center Study Designed to 

Compare Treatment with ARIFLO (Cil)’ GlaxoSmithKline 

12/6/2002 – 8/20/2004 

$84,000.00 



A Multi-Center Randomized, Double-blind, Double-Dummy, Parallel-group Comparison of 

Salmeterol Xinafoate Inhalation Aerosol; Glaxo SmithKline 

11/6/2001 – 9/30/2002 

$38,300.00 



Protocol SPI-001: Evaluation of the Safety and Efficacy of Alph-hANP Infusion (Carpertide for 

Injection: Sun4936) in Patients with …; Suntory Pharmaceutical, Inc. 

11/13/2001 – 8/14/2003 

$50,000.00 



The Use of Polyethylene Glycol Modified Albumin in Hypovolemia 

Department of the Army / Department of Defense 

2/1/2002 – 7/31/2003 

$132,074.00 

Principal Investigator: Ragheb Assaly, Department of Medicine, Medical University of Ohio at 

Toledo 

Asthma Event Outcomes in Subjects Receiving Either Usual Pharmacotherapy of Asthma or 

Usual Pharmacotherapy plus Salmet; Glaxo Wellcome, Inc. 

2/9/2001 – 10/17/2002 

$525.00 



9

Asthma Event Outcomes in Subjects Receiving Either Usual Pharmacotherapy of Asthma or 

Usual Pharmacotherapy plus Salmet; Glaxo Wellcome, Inc. 

2/9/2001 – 10/17/2002 

$1,875.00 



An Open-Label Pilot Study of the Safety and Efficacy of Tobramycin Solution for Inhalation 

(TOBI) for Patients with Severe Bronc; PathoGenesis Corporation 

7/1/2000 – 6/26/2002 

$13,050.00 



CURRENT RESEARCH SUPPORT, TRAINING GRANTS: 

A Randomized Double-blind, Placebo-controlled, Phase-2b Study to Assess the Safety and 

Efficacy Effects of ART-123 on Subjects with Sepsis and Disseminated Intravascular 

Coagulation; Artisan Pharma, Inc. 

2/2009- 2/2012 

$140,000.00 

Ragheb Assaly, M.D, Principal Investigator, University of Toledo College of Medicine 

A Phase 4, Randomized, Double blind, Multi-center, Comparator Study Evaluating the Safety 

of Dexmedetomidline Compared to…; Hospira, Inc. 

3/16/2005 – 3/15/2006 

$20,840.00 

Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo 


A 12-month Double-blind Randomized, Parallel Group, Multicenter Efficacy and Safety Study 

of Symbicort; AstraZeneca, L.P. 

3/14/2005 – 3/13/2006 

$60,000.00 



A Randomized, Double-blind, parallel Group, 52-week Study to Compare the Effect of 

Cluticasone Propionate/Salmeterol DISKUS; GlaxoSmithKline 

10/25/2004 – 3/28/2007 

$72,474.00 



A Multi-center, Randomized, Open-label Phase 3 Study to Compare the Safety and Efficacy on 

Intravenous Doripenem with that…; Peninsula Pharmaceuticals, Inc. 

12/1/2004 – 11/30/2006 

$56,000.00 


10


Linezolid in the Treatment of subjects with Nosocomial Pneumonia Proven to be due to 

Methicillin-Resistant Staphylococcus aurous; Pfizer, Inc. 

12/21/2004 – 12/20/2005 

$64,000.00 



A Phase 3, Multi-Center, Randomized, Placebo-controlled, Double-blind, Three-Arm Study to 

Evaluate the Safety and Efficacy of…; Chiron Corporation 

6/30/2004 – 6/29/2006 

$68,800.00 



A Clinical Study of ONO-6126 

Ono Pharma USA, Inc. 

3/10/2004 – 7/31/2006 

$24,000.00 



Van Gogh - DVT Trial 

Sanofi-Synthelabo Research 

9/6/2003 – 6/16/2006 

$8,000.00 



A Multicenter, International Randomized, Open-label, Assessor-blind, Non-inferiority Study of 

the Efficacy & Safety of Subcutaneous…; Sanofi-Synthelabo Research 

12/8/2003 – 6/17/2006 

$48,000.00 



A Multi-center, Randomized, Double-blind, Double-dummy, Parallel Group, 42-week 

Comparison of Asthma Control in Hyperresp…; GlaxoSmithKline 

2/3/2003 – 1/14/2006 

$68,000.00 



A Double-blind Placebo-controlled, Study of E5564, a Lipid an Antagonist, Administered by 

Twice Daily Intravenous Infusions in…; Eisai Medical Research Inc. 

9/10/2005 – 6/16/2006 

$69,424.00 

11



Effects of Salmeterol/Fluticasone Propionate (Seretide/Viani/Advair) 50/500 ug bd, Salmeterol 

50 ug bd and Fluticasone Propionate; Glaxo Wellcome Inc. 

7/1/2001 – 1/31/2006 

$60,000.00 



TEACHING ACTIVITIES: 

Name of Activity: Core Curriculum, Medical College of Ohio, Toledo, OH 


Attended by: Third and fourth year medical students and Internal Medicine Residents 

on Med III. Medical Intensive Care Unit rotations and Residents from 

Surgery and Anesthesiology rotating with us will attend as well. 

Attendees per session: 15 - 20 

How many per year: Up to15 sessions per year (during my 3 year fellowship training) 

1. Pearls from the American College of Chest Physicians, November 1996. 

2. Minimally Invasive Coronary Artery Bypass Surgery (MIDCAB), New Approach to 

Treating CAD, November 1996. 

3. Adjunctive Drug Therapy of Acute Myocardial Infarction, March 1997. 

4. American Thoracic Review May 1997. 

5. SIRS and Sepsis, New Concepts (Cars, Mods), 1997 

6. Standards for the Diagnosis and Care for Patients with Chronic Obstructive Pulmonary 

Disease, January 1997. 

7. Primary Pulmonary Hypertension, “American College of Chest Physicians” Consensus, 

Pulmonary Core Curriculum, January 1997. 

8. Bronchiolitis Obliterans Organizing Pneumonia, January 1997. 

9. Eosinophilic Lung Disease – Review, February 21, 1997. 

10. Carcinoid Syndrome (Review), Endobronchial Carcinoid – Case Presentation, February 

1997 

11. Drug Related Pulmonary Toxicity – Discuss Clinical Presentation; Pathology, Outcome 

Treatment – Drug Induces Lupus, 1-Criteria for Diagnosis, 2- Drugs Recently 

Associated with Lupus. 

12. An Integrated Approach to Interpretation of Cardiopulmonary Exercise Testing – Basic 

Concepts Part I, April 1997, Pulmonary Core Curriculum, Medical College of Ohio, 

Toledo, OH, April 1997. 

13. Pulmonary Fungal Infections, May 1997. 

14. Pleural Effusion – Overview: Case Presentation – Mesothelioma, May 1997 

15. Common Presentations of Uncommon Diseases May 1997. 

16. CT scans Chest Presentations, December 1997. 

12

17. ICU Protocols – Cost Effectiveness, December 1998. 

18. Acute Eosinophilic Pneumonia Triggered by 2-4-D. A Case Report, January 1998. 

19. Clinical – Pathology Presentation, February 1998. 

20. X-Ray Presentations, February 1998. 

21. Hemodynamic Monitoring in the ICU, July 1998. 

22. Meningoencephalitis in the ICU, August 1998. 

23. Invasive Procedures in a Critical Care Setting, August 1998. 

Name of Activity: Respiratory Care Symposium, Medical College of Ohio, Toledo, OH 


Attended by: Physicians, respiratory therapists, residents, people interceded in the community 

Attendees per session: Once every year or every other year 

How many per year: 200 - 300 

1. Health Consequences of Smoking, November 1998 

2. Assaly RA. Pulmonary Hypertension, November 2000 

Name of Activity: Board Review in Critical Care. Medical College of Ohio, Toledo, OH 


Attended by: Third year medical residents as preparation for the Internal Boards 


How many per year: Once a year. 

Name of Activity: Lecture for Physicians Assistant Program, Medical College of Ohio, 

Toledo, OH, School of Allied Health 


Attended by: Second year Physicians Assistants 

Attendees per session: Once every year 

How many per year: 30 - 40 

1. Sepsis – New Concepts, Physician Assistant Program, January 2, 1997 

2. Sepsis - Basic Concepts, February 1998 

3. Sepsis - Basic Concepts, January 1999 






Name of Activity: Acid Base Disturbances, Medical College of Ohio, Toledo, OH 


Attended by: Second year medical students 

Attendees per session: 10 -15 

How many per year: Once/year 

Name of Activity: Grand Rounds, Medical College of Ohio, Toledo, OH 


Attended by: Medical students, residents and faculty 


How many per year: Once/year 

13

1. Capillary Leak Syndrome, 1999 

2. Sepsis and Multi-Organ Dysfunction, 2000 

3. New Treatment Modalities in Sepsis, 2002 

4. Update on Sepsis Management, 2003 

5. Acute Respiratory Distress Syndrome, 2005 

Name of Activity: Tuesday Subspecialty Conference, Medical College of Ohio, Toledo, OH 


Attended by: Medical students, residents and faculty. 


How many per year: Two lectures/year 

1. Hypertension in the Hospital Setting, April 13 1999 

2. Developing a Curriculum for Residents and Medical Students In Critical Care, 

December 14, 1999 

3. Mechanical Ventilation, March 2001 

4. Asthma: State of the Union, December 12, 2001 

5. Critical Care Review, July 9, 2002 

6. Acute Respiratory Distress Syndrome: Pathophysiology and Management, March 12, 

2002. 

7. Hypertensive emergency, 2003 

8. Teaching In Critical Care Setting, 2004 

Name of Activity: Teaching Scholars Graduation 

Presenter: RA Assaly. 

Attended by: MCO President, Dean and faculty 

Attendees per session: 30 – 40 

How many per year: This was a one time event. 

“Teaching in Critical Care Setting.” Project presented at the graduation of the teaching 

scholars fellowship, Medical College of Ohio, Toledo, OH. Poster session at the Faculty 

Lounge in the campus Hilton Hotel, Toledo, OH, September 1999 

Course Director 

Physical exam training for internal medicine residents and medical students 

Teaching sessions divided in 5 modules to cover all the systems. 

Once a week for 10 weeks/year 

Co-Course Director 

Board Review Internal Medicine 

Community physicians and third year internal medicine residents 

June 2005, May 2006 and May 2007 

Director - Fellow Conference Symposium 

Quarterly 

First conference 11/2005 

Multispecialty conference, clinical and pathological correlation 

Subspecialty fellows, local and community physicians 

Board Review Sessions 

14

Weekly 

8/2007 

Residents (first, second, and third years) 

15

Scientific Publications (peer reviewed): 

BIBLIOGRAPHY 

Anis Toumeh MD, Navpreet Josh MD, Rawan Narwal MD, Ragheb Assaly MD 

Refractory Thrombotic Thrombocytopenic Purpura associated with Primary Sjogren's 

syndrome Treated with Rituximab; a case report" American journal of Therapeutics. 

In Press Accepted Oct 25, 2011 

Assaly, R. Right Axis Deviation I n Systemic Capillary Leak syndrome. 

Ann Intern Med. 2010 6; author reply. 

Torok N. MD , Niazi M. MD , Al Ahwel y. MD, Taleb M. MD, Taji J.MD, Assaly R. MD 

Thrombotic thrombocytopenic purpura associated with anti-glomerular basement membrane 

disease. Accepted June 2010 in Nephrology, Dialysis, and Transplantation Journal. 

Torok N. MD, Donaldson B. MS, Taji j. MD, Abugiazya A. MD, Assaly R. MD. 

Diffuse alveolar damage and recurrent respiratory failure secondary to Sertaline. 

Accepted June 2010 in American journal of Therapeutics. 

Maisa Nazzal, Fadi Safi, Ragheb Assaly. Micafungin induced Thrombotic Thrombocytopenic 

Purpura case report and review of the literature. American Journal of Therapeutics: 19 March 

2010 doi: 10.1097/MJT. 

Asma Taj, Shaffi Kanjwal .Ragheb A. Assaly, Jeffrey R.Hammersley. 

Pulmonary Capillaritis in a classical polyarteritis nodosa. Int J of Pulmonary medicine, 2009 

Volume 11 Number 2. 

Assaly RA, Habib RH, Azizi M, Shapiro JI, Dignam JD. Use of multiple fluorophores for 

evaluating microvascular permeability in control and septic rats. Clinical Science 2008; 114, 

123–130. 

Assaly RA, Habib RH. Intensive intra-operative insulin therapy versus conventional glucose 

management during cardiac surgery. Ann Intern Med. 2007 Oct 2; 147(7): 521 author reply 

522. 

Habib RH, Assaly RA. Dynamic respiratory mechanics measurements for optimization of 

ventilator settings in acute lung injury. Crit Care Med 2007 July; 35(7):1806-7; author reply 

1807-8. 

Avram R, Kleshinski J, Elsamaloty H, Williams J, Assaly, RA. Coronary artery bypasses graft 

pseudoaneurysm: Report of three cases. Eur J Radiol, published online June 18, 2008. 

Mauro LS, Peloquin CA, Schmude K, Assaly R, Malhotra D. Clearance of linezolid 

16

via continuous venovenous hemodiafiltration. Am J Kidney Dis. 2006 Jun; 47(6):e83-6. 

Al-Astal, A., Olson DE, Hammersley JR, Assaly RA, Yoon Y, Willey JC. Acute 

Eosinophilic pneumonia in a 19 y/o male. J Resp Dis 2005, Vol. 26 (8) 361-362. 

Assaly RA, Azizi M, Kennedy DJ, Amauro C, Zaher A, Houts FW, Habib RH, Shapiro JI, 

Dignam JD. Plasma expansion by polyethylene glycol modified albumin. Clinical Science 

2004; 107(3): 263-272. 

Harr M, Roshong-Denk S, Graves T, Elsamaloty H, Coombs R, Durham S, Al-Astal A, Knight 

C, Hernandez D, Olson DE, Crawford E, Amurao G, Sharief I, Hammersley J, Assaly R, Yoon 

Y, Zaher A: The c-myc x E2f-1/p21 interactive gene expression index augments 

cytomorphologic. Diagnosis of lung cancer in fine needle aspirates specimens. J Mol Diag 

2003 5(3): 176-183. 

Assaly RA, Hammersley JR, Olson DE, Farrouk A, Zaher A, Amurao GV, Shelley WB, Shelley 

ED, Amurao CV. Disseminated Blastomycosis: J Am Acad Dermatol, Jan 2003; 48(1): 123-7. 

Assaly RA, Hammersley JR, Olson DE, Shapiro J, Kahaleh MB. Initial evidence of endothelial 

cell apoptosis as a mechanism of systemic capillary leak syndrome. Chest 2001; 20(4):1301- 

1308. 

Amurao GV, Gottwald L, Duggan J, Amurao CV, Assaly RA. Vaccine-era measles in an adult. 

Cutis 2000; 66(5): 337-340. 

Non-Peer Reviewed publications: 

Assaly RA. Manual “Introductory Course in General Clinical Practice at Primary Health Care 

Level”, Jerusalem Medical Council, 1992. 

Abstracts 

September 1998 

Ohio Thoracic Society Meeting, Columbus, Ohio 

1. Assaly RA. Mystery dyspnea in a patient with immunotactoid glomerulopathy. 

2. Assaly RA. Alveolar hemorrhage syndrome with positive lupus serology one month 

following renal transplantation. 

3. Assaly RA. Yellow nail syndrome – Prediction of occult malignancy. 

4. Assaly RA, Olson DE, Hammersley JR, Hamilton R. Dyspnea in a patient with 

Fibrillary glomerulopathy. 

October 1998 

American College of Physicians, Columbus, Ohio 

1. Assaly RA. Blastomycosis misdiagnosed as Cryptococcoses. 

2. Assaly RA. Valproic acid causing metabolic acidosis; Case Report. 

3. Amurao G, Assaly RA. Measles in adults. 

4. Kleshinski J, Assaly RA, Olson D. Herpes simplex encephalitis in the elderly. 

5. Assaly RA. Alveolar hemorrhage – Capillaritis in a classical polyarteritis nodosa. 

17

6. Assaly RA. Yellow nail syndrome. 

7. Assaly RA. Interstitial lung disease in a patient with fibrillary glomerulonephritis. 

8. Singh, A, Assaly RA. Pancreatic encephalopathy, American College of Physicians. 

9. Assaly RA, Hammersley JR, Olson DE. Blastomycosis in a Saudi Arabian young 

female, American College of Physicians. 

10. Ali-Hasan S, Olson DE, Assaly RA. Troponin I as an indicator of sepsis. 

11. Amurao G, Duggan J, Assaly RA. Measles in adults. 

12. Kleshinski J, Assaly RA, Olson DE. Herpes simplex encephalitis in elderly. 

13. Assaly RA, Olson DE, Hammersley JR, McFarland R. Should valproic acid be 

discontinued in patients with seizures who develop high anion gap acidosis 

November 1998 

Critical Care Symposium, Toronto, Canada, 1998 

1. Assaly RA, Hammersley JR, Olson DE. Systemic capillary leak syndrome: Case Report 

and Review. 

2. Assaly RA, Khalil H, Hammersley JR, Olson DE. A very rare entity with successful 

response to antileukotriene systemic capillary leak syndrome - Responsive to 

antileukotriene case report and review of literature. 

3. Assaly RA, Ali-Hasen S, Olson DE, Hammersley JR. Troponin I as a marker for sepsis. 

4. Assaly RA, Olson DE, Hammersley JR, McFarland R. Should valproic acid be 

discontinued in patients with seizures who develop high anion gap acidosis 

5. Assaly RA, Hammersley JR, Olson DE. Acute eosinophilic pneumonia presenting as 

adult respiratory distress syndrome. 


American College of Physicians, Columbus, Ohio 

1. Assaly RA, Acharya J. Systemic lupus associated with Hashimoto’s and pernicious 

anemia with positive antiparietal cell antibodies. 

2. Assaly RA, Lober J, Hammersley J. Systemic capillary leak syndrome. 

3. Assaly RA, Kyobe M, Olson D. Adrenal insufficiency as a cause of fever of unknown 

origin in Intensive Care Unit. 

4. Assaly RA, Ravindiran A, Sharma S. CA 125 elevation in atrial myxoma. 

5. Assaly RA. Hertroff S. Hydrocephalus in neurosarcoidosis. 

6. Assaly RA, Solaiman D. Ceftriaxone causing pseudolithiasis. 

November 1999 

American College of Chest Physicians. Abstracts, published in CHEST, Chicago, Illinois. 

1. Assaly RA, Hammersley JR, Olson DE, Shapiro J, Kahaleh M. Apoptosis of 

endothelial cell as a cause of capillary leak syndrome. 

2. Assaly RA, Hammersley JR. Acute eosinophilic pneumonia presenting as ARDS. 

October 28-30, 2000 

Toronto Critical Care Symposium / Abstract, Toronto, Canada 

1. Assaly R, Amurao G, Hammersley J, Olson DE. “Subcutaneous use of fenoldopam”. 

September 2001 

Ohio Thoracic Society / Abstract, Cambridge, Ohio 

18

1. Amurao GV, Olson DE, Hammersley J, Willey J, Yoon Y, Assaly RA. Subcutaneous 

use of fenoldopam in pulmonary hypertension. 

2. Sharief I, Olson DE, Hammersley J, Amurao GV, Amurao CV Assaly RA. Fibrillary 

glomerulonephritis. 

May 2002 

American Thoracic Society. Published in Am J Respir Criti Care Med (AJRCCM), Atlanta, 

Georgia 

1. Willey JC, Crawford EL, Zaher A, Hammersley JR, Olson DE, Yoon Y, Assaly RA, 

Zahorchak R. Expression analysis of HNF3A, mucini, ICAM1, SPR1, involucrin keratin 

5, neuron specific enolase, and other differentiation specific genes in normal and 

squamous metaplastic bronchial epithelial samples. 

2. Assaly RA, Amurao C, Shapiro JI, Habib RH, Dignam JD. Superior hemodynamic 

resuscitation using a polyethylene glycol modified albumin (PEG-Alb) fluid in rats with 

endotoxin-induced shock”. 

3. Amurao GV, Amurao CV, Assaly RA, Khuder SA, Hammersley JR, Olson DE, Sharief I, 

Willey JC, Yoon Y. Comparison of “Closed” and “Open” Intensive Care Unit (ICU) 

Organizational Models: A Meta-Analysis. 

4. Amurao C, Assaly RA, Shapiro JI, Habib RH, Hammersley JR, Olson DE, Dignam JD. 

Reduced capillary leak and lung injury using a polyethylene glycol modified albumin 

(PEG-Alb) resuscitation fluid in rats with endotoxin-induced shock. 

November 2002 

American College of Chest Physicians / Abstracts published in CHEST, San Diego, CA 

1. Sharief I, Yoon Y, Olson DE, Assaly RA, Hammersley JR. Pericardial tamponade as 

the first manifestation of small cell lung cancer. 

2. Sharief I, Yoon Y, Olson DE, Hammersley JR, Amurao GV, Willey JC, Assaly RA. 

Disseminated mucomycosis in a patient with renal transplant. A Case Report and 

Review of the Literature. 

3. Sharief I, Ellis S, Olson DE, Hammersley JR, Shahin A, Willey JC, Yoon Y, Assaly RA. 

Pulmonary hypertension secondary to tumor-related pulmonary microangiopathy 

simulating primary pulmonary hypertension. 

May 2003 

American Thoracic Society / published American Journal of Respiratory and Critical Care 

Medicine (AJRCCM), Seattle, Washington 

Assaly RA, Dignam D, Habib R, Shapiro J. Superior and more rapid reversal of hypovolemic 

hypotension using polyethylene glycol modified albumin. 


American College of Chest Physicians. Published in CHEST, Orlando, Florida 

Astal A, Olson DE, Hammersley JR, Assaly RA. Allergic bronchopulmonary mycosis 

secondary to Scedosporium Apiospermum in a patient with partial immotile cilia syndrome. 

19

April 14-16, 2005 

American College of Physicians (ACP), San Francisco, CA 

Chahal M, Assaly RA. Constrictive pericarditis in a patient with rheumatoid 

arthritis treated with infliximab. Case presentation accepted for poster 

session, Clinical Vignette Competition. 


American College of Physicians, Ohio Chapter, Columbus, Ohio 

Mikkelini H, Assaly RA. Accelerated IPF, idiopathic pulmonary fibrosis. 

May 2006 

American Thoracic Society Meeting. Abstracts / AJRCCM, San Diego, CA 

Assaly RA, Habib RH, Azizi M, Hernandez D-A, Nadour J, Shapiro JI, Dignam JD. 

Polyethylene glycol modified albumin (PEG-Alb) volume expansion in hemorrhagic shock (HS). 

Assaly RA, Habib RH, Ruiz J, Al-Baghdadi M, Azizi M, Shapiro JI, Dignam JD. Timing and 

quantifying systemic capillary leak via a novel dual fluorescence technique. 


American College of Chest Physicians, 72 nd Annual International Assembly, Salt Lake City, UT 

Al-Baghdadi MW, Assaly R, Ghai V. Cerebral venous sinus thrombosis in a patient with diabetic 

ketoacidosis and predisposition to thrombosis. Chest 130(4) Oct. 2006 supplement. 

Assaly RA, Habib R, Shapiro JI, Azizi M, Dignam D. A novel, double fluorescence technique for 

quantifying intravascular retention of polyethylene glycol albumin 40.000 (PEG-Alb 40.000). Chest 

130(4) October 2006 supplement. 

May 2007 

American Thoracic Society International Meeting, San Francisco, CA 

Assaly RA, Habib R, Azizi M, Al-Baghdadi M, Ruiz J, Shapiro JI, Dignam JD. Polyethylene glycol 

modified albumin at a single site (PEG-Alb 40,000) is at least equivalent to multiply modified 

albumin (5000) in maintaining hemodynamics in a cecal ligation and puncture (CLP) model of 

sepsis. Am J Respir Crit Care Med, April 2007, page A237. 

August 1-5, 2007 

American Task Force on Palestine 

Makassed Teaching Hospital – Jerusalem, Israel 

Lecture series for the residents 


American College of Chest Physicians – Chicago, IL 

Assaly RA, Habib R, Azizi M, Al-Baghdadi M, Ruiz J, Shapiro JI, Dignam JD. Comparisons of 

multiple sizes of PEG-albumins in restoring hemodynamics in septic shock in the rat. 

February 2 - 8, 2008 

20

1 st International Conference on Drug Design and Discovery, Dubai, UAE 

Assaly RA, Habib RH, Azizi M, Shapiro JI, Dignam JD. Plasma expansion by polyethylene 

glycol modified albumin (PEG-Alb). 

April 2009 

American Thoracic Society International Meeting, San Diego, CA. Published in Am J Respir Crit 

Care Med 

Assaly RA, Habib RH, Azizi M, Shapiro JI, Dignam JD. Polyethylene glycol resuscitation in 

hemorrhagic shock in rats. 

October, 2009 

American College of Chest Physicians. October, 2009 San Diego. 

Boughazia, A, Torok, N, Assaly R Lab Acquired Cocciidomycosis 

May, 2010 

American Thoracic Society International Meeting, New Orleans. Published in Am J Respir Crit 

Care Med 

Rajan Goyal, Niazi M, Torok, N, Assaly R 

Abs. ID/Title: #4201 - Carcinoid with Tumorlet syndrome 

Session: D43 - Interesting Cases of Tumors and More 

Session Type: Thematic Poster Session- Poster Presentation 

Date: Wednesday, May 19, 2010 

Time: 8:15 AM-4:00 PM 

Rajan Goyal, Niazi M, Torok, N, Assaly R 

Abs. ID/Title: #7173 - Coexistent TTP and Goodpasture syndrome 

Session: D51 - Strange Rangers in the ICU: Selected Case Reports 

Session Type: Thematic Poster Session- Poster Presentation 

Date: Wednesday, May 19, 2010 

Time: 8:15 AM-4:00 PM 

Jamil Taji, Torok N, Assaly R 

Foreign body granuloma –Case report 

21

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