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ULTIMATE COMPUTING - Quantum Consciousness Studies

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Toward Ultimate Computing 21<br />

(1981) proposed that solitons could propagate through switching circuits made of<br />

branched polyacetylene chains. He has also considered molecular computing in<br />

periodic arrays using electron tunneling, soliton “valving” and photo-activated<br />

conformational changes in lattice materials. He envisions three dimensional<br />

molecular scale memory and switching densities of 10 15 to 10 18 elements per<br />

cubic centimeter, near the theoretical limit for charge separation. A number of<br />

materials may be suitable for soliton switching and biological propagation of<br />

solitons in proteins has been suggested. Several authors have argued for<br />

cytoskeletal solitons mediating information processing (Chapter 8).<br />

Wayne State University’s Michael Conrad has defined his vision of a<br />

molecular computer in which proteins integrate multiple input modes to perform a<br />

functional output (Conrad, 1986). In addition to smaller size scale, protein based<br />

molecular computing offers different architectures and computing dimensions.<br />

Conrad suggests that “non-von Neumann, nonserial and non-silicon” computers<br />

will be “context dependent,” with input processed as dynamical physical<br />

structures, patterns, or analog symbols. Multidimensional conditions determine<br />

the conformational state of any one protein: temperature, pH, ionic<br />

concentrations, voltage, dipole moment, electroacoustical vibration,<br />

phosphorylation or hydrolysis state, conformational state of bound neighbor<br />

proteins, etc. Proteins integrate all this information to determine output. Thus<br />

each protein is a rudimentary computer and converts a complex analog input to<br />

an output state or conformation.<br />

Conrad and Liberman (1982) have defined an “extremal computer” as one<br />

which uses physical resources as effectively as possible for computation. They<br />

suggest that an extremal computer should be a molecular computer, with<br />

individual switches or information representation subunits composed of<br />

molecules. The state of each information. subunit should be coupled to an energy<br />

event near the quantum limit. Protein conformational states leveraged to dipole<br />

oscillations in the nanoscale may be that limit. Conrad and Liberman conclude<br />

that, within biological systems, macromolecular computing occurs by<br />

conformational changes generating “reaction diffusion patterns” of concentrations<br />

of biochemical energy molecules (cyclic AMP).<br />

A 1984 conference (Yates, 1984) considered Chemically Based Computer<br />

Designs (Yates, 1984) and attempted to answer 6 relevant questions. 1) Are there<br />

fundamental, quantum mechanical limitations on computation This question<br />

deals with energy loss due to friction or other factors in computation. The work of<br />

Benioff (1980, 1982), Landauer (1982) and Feynman (1986) lead to the<br />

conclusion that, in principle, computation can be achieved by a frictionless,<br />

energy conserving system. Thus there appear to be no quantum mechanical<br />

limitations on computation. 2) Are there fundamental, thermodynamic limitations<br />

on computation Although there are some computing operations that are<br />

irreversible and dissipative, the work of Landauer (1982) and Bennett (1982)<br />

show that there are no fundamental thermodynamic limitations on computation<br />

per se. 3) Are there fundamental limits to serial processing on digital computers<br />

based on binary switches This question has philosophical implications (does the<br />

universe function through continuous or discrete processes) and so cannot be<br />

answered assuredly. The consensus of the conference was that there are probably<br />

limits on serial, digital computing. 4) What are the practical physical limitations<br />

on computer design There are several practical limitations to the further<br />

miniaturization of digital switching circuits. However those limits probably won’t<br />

be reached for decades. 5) What are the potential contributions of molecular<br />

electronics to digital computer design The conference considered molecular<br />

conformational changes, solitons, charge flow and other approaches. Molecular

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