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ULTIMATE COMPUTING - Quantum Consciousness Studies

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Models of Cytoskeletal Computing 183<br />

perpendicular to the long axis of MT could account for mysterious effects such as<br />

the perpendicular birth of daughter centrioles and inter-MT MAP bridges. Energy<br />

or ion fluxes radiated from MT due to propagating waves would be coherent due<br />

to spatial periodicity of the gaps between the tubulin subunits, and could thus<br />

form the basis of coherent wave interference in a three dimensional hologram.<br />

Coupled to calcium/sol-gel states, holographic cytoplasm may be an<br />

“infoplasmic” canvas for dynamic biological information.<br />

In the brain, highly parallel arrangements of cytoskeletal proteins within<br />

asymmetrical axons and dendrites suggest analogies to parallel computing.<br />

Propagation of action potentials or dendritic depolarization waves could induce<br />

sequences of alterations of MT subunit states due to influx of calcium, alteration<br />

of electrical fields, or direct mechanical effects as sodium and water transiently<br />

swell the nerve process. Signals may cooperatively reverberate throughout the<br />

cytoskeleton by waves of calcium release and uptake, mechanical/electrosolitons<br />

propagating through the cytoskeletal lattice, and/or lateral propagation through<br />

sidearms and other components of the cytoskeletal network. Transient fluxes of<br />

calcium resulting from conformational waves propagating down cytoskeletal<br />

lattices in parallel with action potentials or dendritic current waves can result in<br />

traveling frames of dynamic imagery. Sequences of image frames traveling<br />

through holographic cytoplasm and changing with each nerve firing may<br />

collectively be the “Mind’s Eye, the “grain of the engram.”<br />

The current prevalent model of brain function is the “neural network,” a<br />

collective dynamical system whose output is determined by the states of<br />

component neuronal synapses. In turn, the state of each synapse is determined by<br />

other neurons modulated by collective dynamic effects of the interneuronal<br />

cytoskeleton. In turn, the cytoskeleton is a collective dynamical system whose net<br />

activity is determined by the states of its component subunits. Their states, in turn,<br />

are determined by another level of organization including cytoplasmic factors,<br />

ordered water and ions, genetic isozymes of individual subunits, and lower level<br />

cytoskeletal elements such as the microtrabecular lattice. Each cytoskeletal<br />

subunit is a computer capable of integrating multiple inputs to a specific output<br />

state. Cognitive processes which have been ascribed to a neural net concept may<br />

thus be more accurately interpreted as a fractal hierarchy of dynamical systems<br />

which are highly parallel, highly interconnected, and of increasing capacity as<br />

they become more microscopic. Collective effects may occur at each level and at<br />

successively more macroscopic levels. The net effect may be consciousness.<br />

Microtubules and the cytoskeleton created their place in evolutionary history<br />

by being problem solvers, organelle movers, cellular organizers, and intelligence<br />

circuits. Where do they go from here

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