IonWorks Quattro Assay - Molecular Devices

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Cardiac Na + Channel Mutations

Loss

Gain

Arrhythmia and

Torsades de

Pointes

LQT and

Torsades

de Pointes

â Realizing the potential of IonWorks screening in a drug discovery ...

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Cardiac Na + Channel Mutations Loss Gain Arrhythmia and Torsades de Pointes LQT and Torsades de Pointes

FLIPR-384: ΔVm Can Identify Blockers Na + 12 known blockers A B C Na + -- channel -50mV opener Baseline fluorescence + + +10mV Increased fluorescence Concentration (µM) 0 D E 0.14 F G 0.41 H I 1.23 J K 3.70 L M 11.11 N O 33.33 P 100.00 Range = ( -2000, 60000 )

Page 1 and 2: IonWorks Assays for Nav Channels Bi
Page 3 and 4: Sodium Channel Complexes n n α1 (>
Page 5: Nav1.7 Loss of Function Causes Inse
Page 9 and 10: Blocker Characterization with IonWo
Page 11 and 12: Correlation Between Assays IonWorks
Page 13 and 14: Nav1.5 Block by Propafenone: 80 60
Page 15 and 16: Need for IonWorks Quattro Assay n G
Page 17 and 18: I-V curves of Nav1.7 and Nav1.5 on
Page 19 and 20: Screening Nav1.7 State-Dependent Bl
Page 21 and 22: Nav1.8 currents on IonWorks IonWork
Page 23: Acknowledgements Neuroscience Howar

IonWorks Quattro Assay - Molecular Devices

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