IonWorks Quattro Assay - Molecular Devices

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Nav1.7 Mutations Cause Pain in Human Diseases Point Mutations Over-Active Channels S241T N395K I848T L858H,F A863P F1449V Primary Erythermalgia Paroxysmal Extreme Pain Disorder Nerve Hyperactivity Yang et al, 2004; Cummins et al, 2004 and others
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Page 1 and 2: IonWorks Assays for Nav Channels Bi
Page 3: Sodium Channel Complexes n n α1 (>
Page 7 and 8: FLIPR-384: ΔVm Can Identify Blocke
Page 9 and 10: Blocker Characterization with IonWo
Page 11 and 12: Correlation Between Assays IonWorks
Page 13 and 14: Nav1.5 Block by Propafenone: 80 60
Page 15 and 16: Need for IonWorks Quattro Assay n G
Page 17 and 18: I-V curves of Nav1.7 and Nav1.5 on
Page 19 and 20: Screening Nav1.7 State-Dependent Bl
Page 21 and 22: Nav1.8 currents on IonWorks IonWork
Page 23: Acknowledgements Neuroscience Howar

IonWorks Quattro Assay - Molecular Devices

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