IonWorks Quattro Assay - Molecular Devices
IonWorks Quattro Assay - Molecular Devices
IonWorks Quattro Assay - Molecular Devices
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vinpocetine<br />
verapamil<br />
Tetrodotoxin<br />
tetracaine<br />
Standard 2<br />
standard 1<br />
100<br />
80<br />
60<br />
40<br />
20<br />
hNav1.7 Peak Current<br />
0<br />
IC 50<br />
2.9 µM at -140 mV<br />
IC 50<br />
1.1 µM at -70 mV<br />
120<br />
0.01 0.1 1 10 100<br />
µM<br />
100<br />
80<br />
60<br />
40<br />
20<br />
IC 50<br />
25.7 µM at -140 mV<br />
0<br />
IC 50<br />
11 µM at -70 mV<br />
0.01 0.1 1 10 100<br />
µM<br />
hNav1.7 Peak Current<br />
120<br />
100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
140<br />
120<br />
100<br />
80<br />
60<br />
40<br />
20<br />
State-dependent block of standard Nav<br />
blockers on <strong>Quattro</strong><br />
lamotrigine dibucaine<br />
10000<br />
-140 mV<br />
-70 mV<br />
IC 50<br />
>100 µM at -140 mV<br />
IC 50<br />
87.6 µM at -70 mV<br />
100<br />
0.1 1 10 100 1000<br />
µM<br />
propafenone<br />
verapamil<br />
1<br />
(+/-)-fluoxetine<br />
(+/-)-reboxetine<br />
(R,R)-reboxetine<br />
(S)-(-)bupivacaine<br />
ambroxol<br />
amiodarone<br />
cinnarizine<br />
clomipramine<br />
dibucaine<br />
haloperidol<br />
imipramine<br />
lamotrigine<br />
mexiletine<br />
propafenone<br />
R-(-)-fluoxetine<br />
IC 50<br />
9.9 µM at -140 mV<br />
IC 50<br />
8.1 µM at -70 mV<br />
0.01 0.1 1 10 100<br />
µM<br />
0.01<br />
1E-4<br />
hNav1.7 Peak Current<br />
hNav1.7 Peak Current<br />
IC50 (µM)<br />
riluzole<br />
S-(+)-fluoxetine<br />
0
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