IonWorks Quattro Assay - Molecular Devices
IonWorks Quattro Assay - Molecular Devices
IonWorks Quattro Assay - Molecular Devices
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Nav1.5 Block by Propafenone:<br />
80<br />
60<br />
40<br />
20<br />
Use-dependent block & frequency-dependent IC 50<br />
3.9 µM<br />
Tonic<br />
Block<br />
Use-Dependent<br />
Block<br />
100<br />
0.5 Hz<br />
5 Hz<br />
1.0<br />
Normalized Current<br />
0.5<br />
0, 1 µM<br />
3 µM<br />
Block (%)<br />
1.4 µM<br />
10 µM<br />
0.0<br />
30 µM<br />
0 4 8 12<br />
Pulses<br />
Vh=-120mV<br />
0<br />
0.01 0.1 1 10 100<br />
Propafenone (μM)
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