IonWorks Quattro Assay - Molecular Devices
IonWorks Quattro Assay - Molecular Devices
IonWorks Quattro Assay - Molecular Devices
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Correlation Between <strong>Assay</strong>s<br />
<strong>IonWorks</strong> HT vs. Manual EP<br />
<strong>IonWorks</strong> HT vs. FLIPR<br />
100<br />
3-fold boundary<br />
correlation fit, R 2 = 0.89<br />
1:1 fit<br />
1000<br />
100<br />
cinnarizine<br />
(clogP=6.1)<br />
mexiletine<br />
<strong>IonWorks</strong> HT IC 50<br />
(μM)<br />
10<br />
<strong>IonWorks</strong> IC 50<br />
(μM)<br />
10<br />
1<br />
(+/-)-reboxetine<br />
1<br />
1 10 100<br />
Manual Recording IC 50<br />
(μM)<br />
0.1<br />
Linear Fit, R 2 = 0.68<br />
1:1 correlation<br />
3 fold boundary<br />
TTX<br />
0.01<br />
0.01 0.1 1 10 100 1000<br />
FLIPR IC 50<br />
(μM)
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