the application of next generation sequencing (ngs) in genome studies
the application of next generation sequencing (ngs) in genome studies
the application of next generation sequencing (ngs) in genome studies
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SCIENTIFIC SEMINAR<br />
THE APPLICATION OF NEXT GENERATION<br />
SEQUENCING (NGS) IN GENOME STUDIES<br />
BY: MR. SHI QUAN LI (BEIJING GENOMICS INSTITUTE, ASIA-PACIFIC)<br />
DATE: 21 NOVEMBER 2012 (WED)<br />
TIME: 2:45 PM– 4:00 PM<br />
VENUE: INBIOSIS SEMINAR HALL, UKM BANGI<br />
INTRODUCTION<br />
Next-<strong>generation</strong> <strong>sequenc<strong>in</strong>g</strong> (NGS) has<br />
revolutionized plant and animal research, allow<strong>in</strong>g<br />
us to decode <strong>the</strong> whole <strong>genome</strong>s <strong>of</strong> many species.<br />
NGS also enables us to detect functional genes and<br />
markers <strong>of</strong> important traits to facilitate molecular<br />
breed<strong>in</strong>g and improve agriculture production and<br />
conservation. BGI have been a pioneer <strong>in</strong> this field<br />
and is highly experienced <strong>in</strong> apply<strong>in</strong>g NGS to <strong>the</strong><br />
study <strong>of</strong> plant and animal <strong>genome</strong>s, with state-<strong>of</strong><strong>the</strong>-art<br />
technologies and comput<strong>in</strong>g power, rapid<br />
turn-around time, as well as strong bio<strong>in</strong>formatics<br />
know-how.<br />
Today, as hundreds, perhaps thousands, <strong>of</strong> human<br />
<strong>genome</strong>s are be<strong>in</strong>g sequenced, reference <strong>genome</strong>s<br />
are also be<strong>in</strong>g pursued for numerous o<strong>the</strong>r<br />
creatures with whom we share <strong>the</strong> planet.<br />
Sequenc<strong>in</strong>g <strong>of</strong> whole <strong>genome</strong>s, as well as <strong>the</strong><br />
whole transcriptome, whole methylome study<br />
provides us with a new way to see life and, through<br />
comparisons between and amo<strong>ngs</strong>t species.<br />
BGI’S CASE STUDIES<br />
1. Cucumber/ Panda de novo <strong>genome</strong> <strong>sequenc<strong>in</strong>g</strong><br />
The <strong>genome</strong> <strong>of</strong> cucumber, Cucumis sativus L.<br />
Nature Genetics, 41,12, 1275-1281, (2009)<br />
The sequence and de novo assembly <strong>of</strong> <strong>the</strong><br />
giant panda <strong>genome</strong>. Nature, 463, 311-317,<br />
(2010)<br />
2. Whole Genome Re-<strong>sequenc<strong>in</strong>g</strong><br />
Re<strong>sequenc<strong>in</strong>g</strong> <strong>of</strong> 31 wild and cultivated soybean<br />
<strong>genome</strong>s identifies patterns <strong>of</strong> genetic diversity<br />
and selection.<br />
Nat Genet. 2010 Dec; 42:1053-61. Epub 2010 Nov<br />
Genome-wide patterns <strong>of</strong> genetic variation<br />
among elite maize <strong>in</strong>bred l<strong>in</strong>es. Nat Genet 2010<br />
Nov; 42(11):1027-30. Epub 2010 Oct 24<br />
3. RNA-seq(transcriptome) <strong>sequenc<strong>in</strong>g</strong><br />
Deep RNA <strong>sequenc<strong>in</strong>g</strong> at s<strong>in</strong>gle base-pair<br />
resolution reveals high complexity <strong>of</strong> <strong>the</strong> rice<br />
transcriptome Genome Res 2009<br />
4. Epigenetic Study <strong>in</strong> Maize<br />
TENTATIVE PROGRAMME<br />
2:45 pm – 3:00 pm<br />
REGISTRATION<br />
3:00 pm – 4:00 pm<br />
SEMINAR:<br />
THE APPLICATION OF NEXT GENERATION<br />
SEQUENCING (NGS) IN GENOME STUDIES<br />
Q&A and WRAP-UP<br />
Attendance confirmation should be made no later than<br />
20 November 2012, faxed to 03 89213398, or email to<br />
<strong>in</strong>biosis@gmail.com<br />
Enquiries: Nur Hasr<strong>in</strong>a Mohar<br />
Tel: 03 89214558
REGISTRATION FORM<br />
SCIENTIFIC SEMINAR<br />
THE APPLICATION OF NEXT GENERATION SEQUENCING (NGS)<br />
IN GENOME STUDIES<br />
By: Mr. Shi Quan Li (Beij<strong>in</strong>g Genomics Institute, Asia-Pacific)<br />
Date: 21 November 2012 (Wed)<br />
Name (Pr<strong>of</strong>./Assoc. Pr<strong>of</strong>./Dr./Mr./Mrs./Ms.):<br />
Organization:<br />
Address:<br />
E-mail:<br />
Tel:<br />
Date:<br />
Signature:<br />
As places are limited, early registration is recommended<br />
Institute <strong>of</strong> Systems Biology (INBIOSIS)<br />
Universiti Keba<strong>ngs</strong>aan Malaysia, 43600 UKM Bangi, Selangor, Malaysia<br />
Tel: +603 8921 4558/4549 │ Fax: +603 8921 3398<br />
http://www.<strong>in</strong>biosis.ukm.my
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