2008-2009 Bulletin – PDF - SEAS Bulletin - Columbia University

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surfaces and interfaces. Topics include the characterization
of interfaces, theoretical modeling of
interfacial thermodynamics and structure, and
practical means for surface modification.
CHEN E4660y Biochemical engineering
Lect: 3. 3 pts. Not given in 2008–2009.
Prerequisite: BMEN E4001 or the equivalent.
Engineering of biochemical and microbiological
reaction systems. Kinetics, reactor analysis, and
design of batch and continuous fermentation and
enzyme processes. Recovery and separations in
biochemical engineering systems.
CHEN 4680x Soft materials laboratory
Lect/lab: 3. 3 pts. Professors Koberstein and
Shapley.
Prerequisites: Two years of undergraduate
science courses and the instructors’ permission.
Covers modern characterization methods for soft
materials (polymers, complex fluids, biomaterials).
Techniques include diffential scanning calorimetry,
dynamic light scattering, gel permeation chromatography,
rheology, and spectroscopic methods.
Team taught by several faculty and open to
graduate and advanced undergraduate students
(limit 15).
CHEN E4700x Principles of genomic
technologies
Lect: 3. 3 pts. Professor Ju.
Prerequisites: BIOL C2005 and 2006, CHEM
C3045 and C3046, or equivalents. Chemical
and physical aspects of genome structure and
organization, genetic information flow from DNA
to RNA to protein. Nucleic acid hybridization and
sequence complexity of DNA and RNA. Genome
mapping and sequencing methods. The engineering
of DNA polymerase for DNA sequencing and
polymerase chain reaction, Fluorescent DNA
sequencing and high-throughput DNA sequencer
development. Construction of gene chip and
micro array for gene expression analysis. Technology
and biochemical approach for functional
genomics analysis. Gene discovery and genetics
database search method. The application of
genetic database for new therapeutics discovery.
CHEN E4740x: Biological transport and rate
phenomena, II
Lect: 3. 3 pts. Professor Leonard
Prerequisites: Any two of the following: CHEN
E3110; BIOL C2005; CHEN E3210 or BMCH
E3500. Advanced course intended as preparation
for research. Analysis of transport and rate phenomena
in biological systems and in the design of
biomimetic transport-reaction systems for technological
and therapeutic applications. Modeling of
homogeneous and heterogeneous biochemical
reactions. The bases of biological transport: roles
of convection, ordinary diffusion, forced diffusion.
Systems where reaction and transport interact
strongly. Applications to natural and artificial tissue
beds, tumor modeling, controlled release,
natural and artificial organ function.
Syllabus: Analysis of transport and rate phenomena
in biological systems and in the design of
biomimetic transport-reaction systems for technological
and therapeutic applications.
Homogeneous and heterogeneous biochemical
reactions. Pseudo-homogeneous models.
Free energy changes during reaction; reversibility,
coupled reactions. General approach to modeling
molecular binding to receptors, carriers, and
enzymes. Cooperativity, Hill functions.
Competition and inhibition in binding reactions.
Regulation and regulatory time constants of
enzyme activity. Modeling of polymerases during
transcription and ribosomes during translation.
Bases of biological transport: roles of convection,
ordinary diffusion, forced diffusion. Transport
of electrically neutral and charged species across
membranes. Selective transport mechanisms:
permeases (uniport, comport, antiport), carriers,
endo- and exocytosis. Diffusion in deep stationary
media. Transient diffusion with application to controlled
release systems. Steady-state diffusion in
reacting media with application to metabolizing
tissue beds and tumors. Convective diffusion.
Leveque and Leveque-like formulations with
application to blood-tissue exchange, thrombogenesis,
hollow-fiber therapeutic devices.
Molecular transformation systems involving
both transport and reaction. Rate-limiting step.
Nonequilibrium steady states; the resting cell.
Mitochondrial kinetics. Simple models of cellular
operons.
CHEN E4750y The genome and the cell
Lect: 3. 3 pts. Not given in 2008–2009.
Prerequisite: BIOL C2005 and MATH E1210, or
equivalents. The utility of genomic information lies
in its capacity to predict the behavior of living cells
in physiological, developmental, and pathological
situations. The effect of variations in genome structure
between individuals within a species, including
those deemed healthy or diseased, and among
species, can be inferred statistically by comparisons
of sequences with behaviors, and mechanistically,
by studying the action of molecules whose
structure is encoded within the genome. This
course examines known mechanisms that elucidate
the combined effect of environmental stimulation
and genetic makeup on the behavior of cells in
homeostasis, disease states, and during development,
and includes assessments of the probable
effect of these behaviors on the whole organism.
Quantitative models of gene translation and intracellular
signal transduction will be used to illustrate
switching of intracellular processes, transient and
permanent gene activation, and cell commitment,
development, and death.
CHEN E4760y Genomics sequencing laboratory
Lect: 1. Lab: 2. 3 pts. Professor Ju.
Prerequisites: undergraduate-level biology, organic
chemistry, and the instructor’s permission. The
chemical, biological, and engineering principles
involved in the genomics sequencing process will
be illustrated throughout the course for engineering
students to develop the hands-on skills in conducting
genomics research.
CHEN E4800x Protein engineering
Lect: 3. 3 pts. Professor Banta.
Prerequisite: CHEN E4230 (may be taken
concurrently) or the instructor’s permission.
Fundamental tools and techniques currently used
to engineer protein molecules. Methods used to
analyze the impact of these alterations on different
protein functions, with specific emphasis on
enzymatic catalysis. Case studies reinforce concepts
covered and demonstrate the wide impact
of protein engineering research. Application of
basic concepts in the chemical engineering curriculum
(reaction kinetics, mathematical modeling,
thermodynamics) to specific approaches utilized
in protein engineering.
CHEN E6050y Advanced electrochemistry
Lect: 3. 3 pts. Not given in 2008–2009.
Prerequisite: The instructor’s permission. An
advanced overview of the fundamentals of electrochemistry,
with examples taken from modern
applications. An emphasis is placed on mass
transfer and scaling phenomena. Principles are
reinforced through the development of mathematical
models of electrochemical systems. Course projects
will require computer simulations. The course
is intended for advanced graduate students,
conducting research involving electrochemical
technologies.
CHEE E6220y Equilibria and kinetics in
hydrometallurgical systems
Lect: 3. 3 pts. Professor Duby.
Prerequisite: CHEE E4050 or EAEE E4003.
Detailed examination of chemical equilibria
in hydrometallurgical systems. Kinetics and
mechanisms of homogeneous and heterogeneous
reaction in aqueous solutions.
CHEE E6252y Applied surface and colloid
chemistry
Lect: 2. Lab: 3. 3 pts. Professor Somasundaran.
Prerequisite: CHEN E4252. Applications of surface
chemistry principles to wetting, flocculation,
flotation, separation techniques, catalysis, mass
transfer, emulsions, foams, aerosols, membranes,
biological surfactant systems, microbial surfaces,
enhanced oil recovery, and pollution problems.
Appropriate individual experiments and projects.
CHEN E6300y Experimental fluid mechanics:
Complex fluids and biological applications
Lect: 3. Lab: 2. 3 pts. Professor Shapley.
Prerequisite: CHEN E4110 or equivalent, or the
instructor’s permission. The goal of this course is
to introduce graduate students to several experimental
techniques used to study complex fluids
(materials with internal microstructure that influences
macroscopic flow properties) such as polymer
solutions and melts, suspensions, and emulsions.
The course will focus in depth on rheology and
noninvasive imaging methods such as magnetic
SEAS 2008–2009