2008-2009 Bulletin – PDF - SEAS Bulletin - Columbia University

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medical engineering graduate student interested
in acquiring in-depth knowledge of anatomy relevant
to his/her doctoral research. Lectures and
tutorial sessions may be taken with or without the
associated laboratory (BMEN E4108).
BMEN E4108x Anatomy laboratory: head and
neck
Lab: 2. 2 pts. Professor April.
Prerequisite: graduate standing in biomedical
engineering. Corequisite: BMEN E4107.
BMEN E4210x Thermodynamics of biological
systems
Lect: 4. 4 pts. Professor Sia.
Prerequisites: CHEM C1404 and MATH V1202.
Corequisite: BIOL C2005 or the equivalent.
Introduction to the thermodynamics of biological
systems, with a focus on connecting microscopic
molecular properties to macroscopic states. Both
classical and statistical thermodynamics will be
applied to biological systems; phase equilibria,
chemical reactions, and colligative properties.
Topics in modern biology, macromolecular behavior
in solutions and interfaces, protein-ligand binding,
and the hydrophobic effect.
BMEN E4300y Solid biomechanics
Lect: 3. 3 pts. Professor Mow.
Prerequisites: ENME-MECE E3105 and ENME
E3113. This course introduces applications of
continuum mechanics to the understanding of
various biological tissue properties. The structure,
function, and mechanical properties of various
tissues in biological systems, such as blood
vessels, muscle, skin, brain tissue, bone, tendon,
cartilage, ligaments, etc., will be examined. The
focus will be on the establishment of basic governing
mechanical principles and constitutive relations
for each tissue. Experimental determination
of various tissue properties will be introduced and
demonstrated. The important medical and clinical
implications of tissue mechanical behavior will be
emphasized.
BMEN E4301x Structure, mechanics, and
adaptation of bone
Lect: 3. 3 pts. Not given in 2008–2009.
Introduction to structure, physiology, and biomechanics
of bone. Structure, function, and physiology
of skeletal bones; linear elastic properties of cortical
and trabecular bone; anisotropy and constitutive
models of bone tissue; failure and damage
mechanics of bone; bone adaptation and fracture
healing; experimental determination of bone
properties; and morphological analysis of bone
microstructure.
BMEN E4305y Cardiac mechanics
Lect: 3. 3 pts. Not given in 2008–2009.
Prerequisites: BMEN E3310 and E3320 or equivalents.
Cardiac anatomy, passive myocardial constitutive
properties, electrical activation, ventricular
pump function, ventricular-vascular coupling,
invasive and noninvasive measures of regional
and global function, models for predicting ventricular
‘wall stress. Alterations in muscle properties
and ventricular function resulting from myocardial
infarction, heart failure, and left ventricular assist.
BMEN E4340y Biomechanics of cells
Lect: 3. 3 pts. Professor Huang.
Prerequisites: BMEN E3310 and E3320 or equivalents.
Survey of experiments and theoretical
analyses of the mechanical behavior of individual
living nonmuscle cells. Emphasis on quantitative
analytic description using continuum mechanics
and molecular level theory from the standpoint
of statistical mechanics and mechanical models.
Mechanics of erythrocytes, leukocytes, endothelial
cells, and fibroblasts; models of aggregation,
adhesion, locomotion, amoeba motility, cell division
and morphogenesis; molecular level models
of actin, myosin, microtubules, and intermediate
filaments and relation to mechanical properties
of cells and cytoskeleton. Alternative models of
cytoskeletal mechanics, foam theory, tensegrity.
Analysis of experimental techniques including
micropipette studies, optical and magnetic cytometry,
and nano-indentation.
BMEN E4400x Wavelet applications in
biomedical image and signal processing
Lect: 3. 3 pts. Professor Laine.
Prerequisite: the instructor’s permission. An introduction
to methods of wavelet analysis and
processing techniques for the quantification of
biomedical images and signals. Topics include
frames and overcomplete representations, multiresolution
algorithms for denoising and image
restoration, multiscale texture segmentation and
classification methods for computer-aided diagnosis.
BMEN E4410y Principles of ultrasound in
medicine
Lect: 3. 3 pts. Professor Konofagou.
Prerequisite: Calculus, Fourier analysis. Physics
of diagnostic ultrasound and principles of ultrasound
imaging instrumentation. Propagation of
plane waves in lossless media; ultrasound propagation
through biological tissues; single-element
and array transducer design; pulse-echo and
Doppler ultrasound instrumentation, performance
evaluation of ultrasound imaging systems using
tissue-mimicking phantoms, ultrasound tissue
characterization; ultrasound nonlinearity and bubble
activity; harmonic imaging; acoustic output of
ultrasound systems; biological effects of ultrasound.
BMEN E4420y Biomedical signal processing
and signal modeling
Lect: 3. 3 pts. Professor Hielscher.
Prerequisites: APMA E3101 and ELEN E3202,
or the instructor’s permission. Fundamental concepts
of signal processing in linear systems and
stochastic processes. Estimation, detection, and
filtering methods applied to biomedical signals.
Harmonic analysis, auto-regressive model,
Wiener and matched filters, linear discriminants,
and independent components. Methods are
developed to answer concrete questions on specific
data sets in modalities such as ECG, EEG,
MEG, Ultrasound. Lectures accompanied by data
analysis assignments using MATLAB.
BMEN E4430x Principles of magnetic
resonance imaging
Lect: 3. 3 pts. Professor Brown.
Prerequisite: APMA E1201, PHYS C1403, or the
instructor’s permission. Fundamental principles
of Magnetic Resonance Imaging (MRI), including
the underlying spin physics and mathematics of
image formation with an emphasis on the application
of MRI to neuroimaging, both anatomical and
functional. The course will examine both theory
and experimental design techniques.
BMEN E4440y Physiological control systems
Lect: 3. 3 pts. Professor Chbat.
Prerequisites: APMA E2101 and instructor’s permission
or senior standing. Dynamic system modeling
and simulation of cardiovascular, respiratory,
and thermoregulatory systems. Open and closed
physiological loops. Internal and external controllers:
baroreflex, chemoreflex, and ventilator.
Fundamentals of time and frequency domain
analyses and stability. Emulation of normal and
pathophysiological conditions. Clinical relevance
and decision support. Matlab and SIMULINK
programming environments will be utilized.
BMEN E4450y Dental and craniofacial tissue
engineering
Lect: 3. 3 pts. Professor Mao.
Prerequisites: MSAE E3103, BMEN E4210, and
BMEN E4501 or equivalent. Principles of dental
and craniofacial bioengineering, periodontal tissue
engineering; beyond guided tissue regeneration,
craniofacial regeneration by stem cells and
engineered scaffolds, biomaterials. Engineering
approaches in tissue regeneration, bone biology
and development; instructive cues for tissue engineers.
BMEN E4501x Tissue engineering, I:
biomaterials and scaffold design
Lect: 3. 3 pts. Professor H. H. Lu.
Prerequisites: BIOL C2005-C2006, BMEN
E4001-E4002. An introduction to the strategies
and fundamental bioengineering design criteria in
the development of biomaterials and tissue engineered
grafts. Material structural-functional relationships,
biocompatibility in terms of material and
host responses. Through discussions, readings,
and a group design project, students acquire an
understanding of cell-material interactions and
identify the parameters critical in the design and
selection of biomaterials for biomedical applications.
BMEN E4502y Tissue engineering, II:
biological tissue substitutes
Lect: 3. 3 pts. Professor Hung.
Prerequisites: BIOL C2005-C2006 and BMEN
E4001-E4002. An introduction to the strategies
and fundamental bioengineering design criteria
SEAS 2008–2009