Volume 8 Issue 1 (pdf) - Andrew John Publishing Inc
Volume 8 Issue 1 (pdf) - Andrew John Publishing Inc
Volume 8 Issue 1 (pdf) - Andrew John Publishing Inc
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found that the incidence of audiogenic<br />
seizure was suppressed by treatment of<br />
vigabatrin, an antiepileptic drug that<br />
inhibits the catabolism of the gammaaminobutyric<br />
acid (GABA), the major<br />
inhibitory neurotransmitter in the brain.<br />
Acute injections (250 mg/kg) or oral<br />
intake (60 mg/kg/day for 7 days)<br />
temporarily abolished audiogenic<br />
seizure in rats with early age tympanic<br />
membrane perforation. Vigabatrin<br />
treatment also caused prolonged ABR<br />
latency and reduced the peak amplitude<br />
of the ABR responses. Collectively, these<br />
results suggest that early age hearing<br />
loss may reduce GABAergic inhibition,<br />
leading to hyperexcitability and<br />
increased susceptibility to audiogenic<br />
seizure. Our results support our<br />
hypothesis that early age hearing loss<br />
affects the normal development of the<br />
central auditory system and disrupts<br />
sound perception and tolerance. It is<br />
possible that our findings may be<br />
related to hyperacusis seen in children<br />
with recurrent otitis media.<br />
aCKnoWLedgeMent<br />
The project was supported by Action of<br />
Hearing Loss foundation.<br />
referenCes<br />
1. O'Leary SJ, Triolo RD. Surgery for<br />
otitis media among Indigenous<br />
Australians. Med J Aust<br />
2009;191:S65–8.<br />
2. Coelho CB, Sanchez TG, Tyler RS.<br />
Hyperacusis, sound annoyance,<br />
and loudness hypersensitivity in<br />
children. Prog Brain Res 166;169–<br />
78.<br />
3. Chang EF, Merzenich MM.<br />
Environmental noise retards<br />
auditory cortical development.<br />
Science 2003;300:498–502.<br />
4. Kral A, Hartmann R, Tillein J, Heid<br />
S, Klinke R. Hearing after<br />
congenital deafness: central<br />
auditory plasticity and sensory<br />
deprivation. Cereb Cortex<br />
2002;12:797–807.<br />
5. Sun W, Manohar S, Jayaram A, et al.<br />
Early age conductive hearing loss<br />
causes audiogenic seizure and<br />
hyperacusis behavior. Hear Res<br />
2011;282:178–83.<br />
Canadian Hearing Report 2013;8(1):49-50.<br />
Save the date!<br />
Canadian Academy of Audiology<br />
Heard. Understood.<br />
Académie canadienne d’audiologie<br />
Entendus. Compris.<br />
16th Annual CAA<br />
Conference and Exhibition<br />
October 16 to 19, 2013 in St. <strong>John</strong>’s Newfoundland<br />
50 CANADIAN HEARING REPORT | REVUE CANADIENNE D’AUDITION
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