Annual Activities Report 2011 - INCT-Inofar - UFRJ

Annual Report 2011 | INCT-INOFAR
45
Highlights
Figure 3: Quercetin (1) reduced human neutrophil F-actin polymerization induced by CXCL8, LTB4,
and fMLP.
These results showed in this work suggest that quercetin inhibits neutrophil recruitment by inhibiting
cellular signaling responsible for actin polymerization, indicating that treatment with this flavonoid is a
conceivable approach to control excessive neutrophil recruitment during inflammation and to prevent
neutrophil-mediated tissue lesions.
Tadalafil analgesia in experimental
arthritis involves suppression of
intra-articular TNF release.
F.A.C., Rocha; F.S., Silva Jr; A.C.R.M., Leite; A.K.R.M., Leite; V.C.C., Girão; R.R., Castro;F.Q., Cunha.
Brit. J. Pharmacol. 164 (2011) 828–835.
DOI: 10.1111/j.1476-5381.2011.01469.x
Modulation of pro-inflammatory and anti-inflammatory mediators by specific phosphodiesterase (PDE)
inhibitors is a growing strategy for the treatment of inflammatory diseases. In the present study, we
investigated the antinociceptive activity of tadalafil (a phosphodiesterase-5 inhibitor) in two models of
arthritis, induced by zymosan or by transection of the anterior cruciate ligament, in rats. The treatment
with tadalafil (0.5 mg/kg, p.o.) reduced the joint pain, that was measured and expressed as the paw elevation
time (PET) on both models of arthritis (zymosan and transection of the anterior cruciate ligament) (Fig.1).
Pretreatment with ODQ prevented the anti-inflammatory effects of tadalafil (Fig. 1 and Table 1).