Annual Activities Report 2011 - INCT-Inofar - UFRJ
Annual Activities Report 2011 - INCT-Inofar - UFRJ
Annual Activities Report 2011 - INCT-Inofar - UFRJ
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<strong>Annual</strong> <strong>Report</strong> <strong>2011</strong> | <strong>INCT</strong>-INOFAR<br />
44<br />
Highlights<br />
Figure 1: Treatment with quercetin (1) inhibits neutrophil recruitment in vivo, induced by different<br />
stimuli.<br />
Furthermore, quercetin also inhibited the chemoattraction of human neutrophils induced by CXCL-<br />
8, LTB4 and fMLP in a Boyden chamber (Fig 2). In vitro treatment with quercetin did not affect<br />
human neutrophil surface expression of CXCR1, CXCR2, BLT1, or FLPR1, but rather reduced actin<br />
Polymerization (Fig.3).<br />
Figure 2: Quercetin (1) inhibits human neutrophil chemoattraction in the Boy den chamber.
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