Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,2-Dichloropropane TDI oral Organisation Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) International Agency for Research on Cancer (IARC) Target organ/Critical Effect Reference Web link Cytogenetic abortions Risk Assessment of Mixtures of Pesticides and Similar Substances cot.food.gov.uk/pdfs/reportindexed.pdf http://inchem.org/documents/iarc/vol71/084-12dichlprop.html IPCS Environmental Health Criteria (EHC) Monographs WHO Guidelines for drinking water Quality Testicular degeneration and in increased number of degenerate spermatogonia in the epididymis Environmental Health Criteria 146 1,2-Dichloropropane (1,2-DCP) in Drinking-water Background document for development of WHO Guidelines for Drinking-water Quality http://inchem.org/documents/ehc/ehc/ehc146.htm http://www.who.int/water_sanitation_health/dwq/1,2-Dichloropropane.pdf US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels Hepatic Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Public Health Service, In collaboration with U.S. Environmental Protection Agency (EPA) December 1989. TOXICOLOGICAL PROFILE FOR 1,2-DICHLOROPROPANE http://www.atsdr.cdc.gov/substances/toxsubstance.asptoxid=162 USEPA Integrated Risk Information System (IRIS) http://www.epa.gov/ncea/iris/subst/0601.htm TDI inhal Organisation Response Reference Web link US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) Necretic liver lesions. Study inadequate - not feasible to derive PPRTV Heppel, L.A., B. Highman and E.G. Peake. 1948. Toxicologicy of 1,2- dichloropropane (propylene bichloride) IV. Effects of repeated exposures to a low concentration of the vapour. J. Ind Hyg. Toxicol. 30: 189-191 USEPA Integrated Risk Information System (IRIS) LOAEL is based on nasal epithelial hyperplasia in female rats Nitschke K.D., K.A. Johnson, D.L. Wackerle, J.E. Phillips and D.A. Dittenber. 1988. Propylene dichloride: A 13-week inhalation toxicity study with rats, mice, and rabbits. Dow Chemical Company, Mammalian and Environmental Toxicology Research Laboratory, Midland, MI. OTS Doc. #86-870001397 http://www.epa.gov/ncea/iris/subst/0601.htm#refinhal ID oral Organisation Response Reference Web link ID inhal Organisation Response Reference Web link Page 2 of 2 EIC proforma 1,2-dichloropropane.xls 28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,2 dichloropropane CAS 78-87-5 Assessor A: D Brooks, Sirius Assessor B: J Lymer, Wardell Armstrong Final review: Panel/SF Date 14/04/2009 Date 13/03/2009 Date 28/08/2009 MDI Recommended MDIoral Units 38 ug day-1 Justification: Value chosen is only available data and is likely to be conservative Organisation Date Media Value Units Description Reference Web link WHO Guidelines for Drinking 2003 Drinking water 38 ug day-1 Estimated maximum daily exposure for an adult http://www.who.int/water_sanitation_health/dwq/chemicals/12dichloropropane/en/ www.who.int/water_sanitation_health/dwq/guidelines/en Water Quality consuming 2 litres of water per day MDI Recommended MDIinh Units 5.2 ug day-1 Justification: Value chosen is only available data and is likely to be conservative Organisation Date Media Value Units Description Reference Web link WHO Guidelines for Drinking Water Quality 2003 Air concentration 5.2 ug day-1 Estimated exposure to 1,2-DCP based on average concentration measured in urban/suburban air in 1982 in Japan (0.26 ug/m3) assuming an air intake of 20m3/day http://www.who.int/water_sanitation_health/dwq/chemicals/12dichloropropane/en/ www.who.int/water_sanitation_health/dwq/guidelines/en Page 1 of 1 EIC proforma 1,2-dichloropropane.xls 28/08/2009
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