Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948
1,2-Dichloropropane
TDI oral
Organisation
Committee on the Toxicity of Chemicals in
Food, Consumer Products and the
Environment (COT)
International Agency for Research on Cancer
(IARC)
Target organ/Critical Effect Reference Web link
Cytogenetic abortions Risk Assessment of Mixtures of Pesticides and Similar Substances cot.food.gov.uk/pdfs/reportindexed.pdf
http://inchem.org/documents/iarc/vol71/084-12dichlprop.html
IPCS Environmental Health Criteria (EHC)
Monographs
WHO Guidelines for drinking water Quality
Testicular degeneration and in increased
number of degenerate spermatogonia in
the epididymis
Environmental Health Criteria 146
1,2-Dichloropropane (1,2-DCP) in Drinking-water Background document for
development of WHO Guidelines for Drinking-water Quality
http://inchem.org/documents/ehc/ehc/ehc146.htm
http://www.who.int/water_sanitation_health/dwq/1,2-Dichloropropane.pdf
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
Hepatic
Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Public Health
Service, In collaboration with U.S. Environmental Protection Agency (EPA)
December 1989. TOXICOLOGICAL PROFILE FOR 1,2-DICHLOROPROPANE
http://www.atsdr.cdc.gov/substances/toxsubstance.asptoxid=162
USEPA Integrated Risk Information System
(IRIS)
http://www.epa.gov/ncea/iris/subst/0601.htm
TDI inhal
Organisation
Response Reference Web link
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
Necretic liver lesions. Study inadequate -
not feasible to derive PPRTV
Heppel, L.A., B. Highman and E.G. Peake. 1948. Toxicologicy of 1,2-
dichloropropane (propylene bichloride) IV. Effects of repeated exposures to a
low concentration of the vapour. J. Ind Hyg. Toxicol. 30: 189-191
USEPA Integrated Risk Information System
(IRIS)
LOAEL is based on nasal epithelial
hyperplasia in female rats
Nitschke K.D., K.A. Johnson, D.L. Wackerle, J.E. Phillips and D.A. Dittenber.
1988. Propylene dichloride: A 13-week inhalation toxicity study with rats, mice,
and rabbits. Dow Chemical Company, Mammalian and Environmental
Toxicology Research Laboratory, Midland, MI. OTS Doc. #86-870001397
http://www.epa.gov/ncea/iris/subst/0601.htm#refinhal
ID oral
Organisation
Response Reference Web link
ID inhal
Organisation
Response Reference Web link
Page 2 of 2 EIC proforma 1,2-dichloropropane.xls 28/08/2009