Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948
Contaminant Name:1,2,4-Trimethylbenzene
TDI oral
Organisation
Description Target organ/Critical Effect Reference Web link
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
Office of Environmental Health Hazard
Assessment
The database for 1,2,4-trimethylbenzene is
inadequate to derive a provisional RfD
Groups of 10 male and 10 female Sprague-
Dawley rats were administered 1,3,5-TMB by
gavage in corn oil.
n/a n/a http://rais.ornl.gov/tox/unauthorized.shtml
Abnormal clinical observations consisted of IITRI (1995). 90-Day oral gavage toxicity study of 1,3,5-trimethylbenzene in
discoloured and/or wet inguinal fur and rats with a recovery group. Industry Institute of Toxicology Research Institute.
salivation in the highest dose group of both Study conducted for Koch Industries Inc., Wichita, KS.
sexes. Critical effects included increases in
mean absolute liver weight and mean
relative kidney weight.
http://oehha.ca.gov/water/pals/124135tmb.html
Risk Assessment Information System
Not provided
dec in body wt gain; clinical observations;
inc liver/kidney wt in rats
IITRI (1995). 90-Day oral gavage toxicity study of 1,3,5-trimethylbenzene in http://rais.ornl.gov/tox/rap_toxp.shtml
rats with a recovery group. Industry Institute of Toxicology Research Institute.
Study conducted for Koch Industries Inc., Wichita, KS.
Texas Commission on Environmental
Quality
The value is provided by the US EPA National
Centre for Environmental Assessment (NCEA)
Not provided Not provided http://www.tceq.state.tx.us/remediation/rrr.html
TDI inhal
Organisation
Health and Safety Executive (HSE)
Description Response Reference Web link
8 hour long term workplace exposure limit Not provided Not provided http://www.hse.gov.uk/
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
male and female rats exposed to 97% pure 1,2,4-
tmb. Battig et al (1958) and Korsak et al (1997)
provide supporting evidence.
decreased clotting time in female rats
Korsak et al, 2000. sub-chronic inhalation toxicity of 1,2,4-trimethylbenzene
(speudocumene) in rats. Int. J. Occup. Med. Environ. Health. 13(2):155-164
http://rais.ornl.gov/tox/unauthorized.shtml
Risk Assessment Information System
Texas Commission on Environmental
Quality
Not provided
The value is provided by the US EPA National
Centre for Environmental Assessment (NCEA)
CNS effects, asthma-like bromchitis, Battig et al 1958
http://rais.ornl.gov/tox/rap_toxp.shtml
aneima, blood clot effects
Not provided Not provided http://www.tceq.state.tx.us/remediation/rrr.html
ID oral
Organisation
Description Response Reference Web link
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
There are no appropriate human or animal data
from which to derive an oral slope factor
n/a n/a http://rais.ornl.gov/tox/unauthorized.shtml
ID inhal
Organisation
Description Response Reference Web link
(Page 2 of pages]) (EIC proforma 1,2,4-trimethylbenzene.xls 28/08/2009)