Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Contaminant Name:1,2,4-Trimethylbenzene CAS Number: 95-63-6 Assessor A: Mathew Rouge Assessor B: Gareth Wills Final Review: Panel/SF<br />
Date: Mar-09 Date: Apr-09 Date: 28/08/2009<br />
Oral Dermal Inhalation Combine Oral<br />
and Inhalation<br />
TDIs<br />
Justification<br />
Apply TDIoral to exposure routes<br />
Apply IDoral to exposure routes<br />
Apply TDIinh to exposure routes<br />
Apply IDinh to exposure routes<br />
No No No<br />
No No No<br />
Yes Yes Yes<br />
No No No<br />
Yes<br />
Route-to-route extrapolation from inhalation to<br />
oral and dermal routes. No in<strong>for</strong>mation available<br />
regarding carcinogencity<br />
TDIinh applied to inhalation route. No<br />
in<strong>for</strong>mation available regarding carcinogencity<br />
TDI oral<br />
Recommended<br />
TDIoral<br />
none<br />
Units<br />
ug.kg-1.d-1<br />
Justification<br />
No recommended TDIoral, insufficient data with sufficient detail on derivation to derive. Use route-to-route extrapolation from inhalation.<br />
Organisation Web Link Last Updated Date Web Checked <strong>Health</strong> criteria type Value Initial Units CLEA units ug.kg-<br />
1.d-1<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
Office of Environmental <strong>Health</strong> Hazard<br />
<strong>Assessment</strong><br />
Confidence<br />
rating<br />
Basis Value Units UF UF description Study type<br />
http://rais.ornl.gov/tox/unauthorized.shtml 2009 Jul-09 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a<br />
http://oehha.ca.gov/water/pals/124135tmb.<br />
html<br />
2001 Jul-09 Sub chronic RfD 47.66 ug/kg bw/day 47.66 Not provided NOAEL 143 mg/kg-day 3000 10 <strong>for</strong> interspecies extrapolation, 10<br />
<strong>for</strong> extrapolation from subchronic to<br />
chronic study, 10 <strong>for</strong> human<br />
variability, 3 <strong>for</strong> database deficiencies.<br />
Subchronic rat<br />
study<br />
<strong>Risk</strong> <strong>Assessment</strong> In<strong>for</strong>mation System http://rais.ornl.gov/tox/rap_toxp.shtml 2008 Mar-09 RfD 50 ug/kg bw/day 50 Low NOAEL Not provided Not provided 3000 Not provided rat<br />
Texas Commission on Environmental<br />
Quality<br />
http://www.tceq.state.tx.us/remediation/rrr.<br />
html<br />
2008 Mar-09 RfD 50 ug/kg bw/day 50 Not provided Not provided Not provided Not provided Not provided Not provided No info.<br />
TDI inhal<br />
Recommended<br />
TDIinhal Units<br />
2 ug.kg-1.d-1<br />
Justification<br />
TDIinhalation based upon provisional RfC. Korsak (2000) study is the primary source, with supporting in<strong>for</strong>mation from Korsak et al (1997) and Battig et al (1958).<br />
Organisation Last Updated <strong>Health</strong> criteria type Value Initial Units CLEA units ug.kg-<br />
1.d-1<br />
<strong>Health</strong> and Safety Executive (HSE) http://www.hse.gov.uk/ 2007 Mar-09 Workplace Exposure<br />
Limit<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
125 (All<br />
trimethylbenzen<br />
e isomers)<br />
mg/m3<br />
35714.29 ug/kg<br />
bw/day<br />
Confidence<br />
rating<br />
Basis Value Units UF UF description Study type<br />
Not provided Not provided Not provided Not provided Not provided Not provided Not provided<br />
http://rais.ornl.gov/tox/unauthorized.shtml 2007 Jul-09 p-RfC 7.00E-03 mg/m3 2 ug/kg bw/d low NOAEL 21.8 mg/m3 3000 10 <strong>for</strong> subchronic to chronic<br />
extrapolation, 3 <strong>for</strong> animal to human<br />
extrapolation, 10 <strong>for</strong> interindividual<br />
variability and 10 <strong>for</strong> database<br />
deficiencies<br />
<strong>Risk</strong> <strong>Assessment</strong> In<strong>for</strong>mation System http://rais.ornl.gov/tox/rap_toxp.shtml 2008 Mar-09 RfC 7.00E-03 mg/m3 2 ug/kg bw/d low NOAEL 21.8 mg/m3 3000 No details provided <strong>Human</strong> study<br />
subchronic rat<br />
study<br />
Texas Commission on Environmental<br />
Quality<br />
http://www.tceq.state.tx.us/remediation/rrr.<br />
html<br />
2008 Mar-09 RS-ESL 6.00E-03 mg/m3 1.71 ug/kg bw/d Not provided Not provided Not provided Not provided Not provided Not provided Not provided<br />
ID oral<br />
Organisation Web Link Last Updated Date Web Checked Non threshold<br />
effects<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
Recommended<br />
IDoral<br />
N/A<br />
Basis<br />
Units<br />
<strong>Health</strong> criteria<br />
type<br />
Justification<br />
No in<strong>for</strong>mation available regarding carcinogencity<br />
Value Units Confidence rating<br />
Basis<br />
Study type<br />
http://rais.ornl.gov/tox/unauthorized.shtml 2007 Jul-09 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a<br />
ID inhal<br />
Organisation Web Link Last Updated Date Web Checked Non threshold<br />
effects<br />
Recommended<br />
IDinhal<br />
N/A<br />
Basis<br />
Units<br />
<strong>Health</strong> criteria<br />
type<br />
Justification<br />
No in<strong>for</strong>mation available regarding carcinogencity<br />
Value Units Confidence rating<br />
Basis<br />
Study type<br />
(Page 1 of pages]) (EIC pro<strong>for</strong>ma 1,2,4-trimethylbenzene.xls 28/08/2009)
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