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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,1-Dichloroethene CAS 75-35-4 Assessor A: Cheryl Davies, De Assessor B: Siân Jones, Entec Final Review: Panel/SF Date Mar-09 Date 29-Apr-09 Date 25/08/2009 MDI Recommended MDIoral 6 Units ug day-1 Justification: Calculated for a 70 kg adult drinking 2 litres of water per day, from mean concentration within drinking water of 0.003 mg.L-1 (IPCS CICADS) Organisation Date Media Value Units Description Reference Web link International Agency for 1990 Drinking water 20 ug litre-1 Maximum level reported Research on Cancer (IARC) in drinking water (US) IPCS Concise International Chemical Assessment Documents (CICADs) 2003 Drinking water 6 to 9x10 -5 mg.kg bw-1.d- 1 Calculated for a 70 kg adult drinking 2 litres of water per day, from mean concentration within drinking water of 0.002 to 0.003 mg.litre-1. The oral exposure from food and soil is most likely negligible Not given but is within http://www.inchem.org/d ocuments/ehc/ehc/ehc10 0.htm http://inchem.org/docum ents/cicads/cicads/cicad5 1.htm#11.1 http://inchem.org/pages/i arc.html http://inchem.org/pages/ cicads.html IPCS Environmental Health Criteria (EHC) Monographs 1990 Drinking water
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,1-Dichloroethene CAS 75-35-4 Assessor A: Cheryl Davies, De Assessor B: Siân Jones, Entec Final Review: Panel/SF Date Mar-09 Date 29-Apr-09 Date 25/08/2009 MDI Recommended MDIinh Units 0.4 ug day-1 Justification: Based on median urban air concentrations is the USA for nonindustrial source area of 20 ng/m³ (EHC Monographs). Converted to MDI of 0.4 ug/d (20 ng/m3 x 20 m3/d / 1000 ng/ug). Organisation Date Media Value Units Description Reference Web link Health and Safety Executive 2005 Air 40 mg.m-3 over 8 www.hse.gov.uk hr TWA Vinylidine Chloride Long term Occupational Exposure Limit 10 ppm or 40 mg.m-3 over 8 hr TWA (workplace exposure, not typical background) EH40/2005 http://www.hse.gov.uk/c oshh/table1.pdf IPCS Concise International Chemical Assessment Documents (CICADs) IPCS Environmental Health Criteria (EHC) Monographs Health Canada Toxicological Reference Values 2003 Air 4 μg.m-3 Upper end of the range for the mean concentration of 1,1-DCE in air will not exceed 0.004 mg/m3 (equivalent to MDIinhal of 80μg/day) 1990 Air 8.7 μg.m-3 Median urban air concentrations is the USA for non-industrial source area is 20 ng/m³. Median for industrial is 8.7 ug.m3 (equivalent to MDIinhal of 174μg/day) 2005 Indoor Air 0.81 ug.kg bw -1.d- 1 US EPA (2002a) AirData. http://inchem.org/pages/ Washington, DC, US cicads.html Environmental Protection Agency, at website http://www.epa.gov/aqsp ubl1/annual_summary.ht ml. US EPA (1985) Health assessment document for vinylidene chloride, Washington, DC, US Environmental Protection Agency, Office of Health and Environmental Assessment (EPA 600/8- 83- 031F). Estimated adult indoor air http://www.hc- inhalation intake, sc.gc.ca/ewh- assuming age 20-59, weight 70 kg and breathes 16.2 m3 air.day-1 and spends 21 hours per day indoors. Based on Canadian study of indoor air within 75 houses in Ottawa by Health Canada, 2003. (equivalent to MD semt/alt_formats/hecs- sesc/pdf/pubs/contamina nts/dichloroethene/dichlo roethene-eng.pdf http://inchem.org/pages/ ehc.html www.hcsc.ga.ca/index_e.html US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk Levels May-94 Ambient Air 6.5 ug m-3 Average background exposure to the general Wallace LA. 1991. Comparison of risks from population (U.S) based on outdoor and indoor air samples from 350 homes in New Jersey exposure to toxic chemicals. Environ Health (equivalent to MDIinhal of Perspect 95:7-1X 130μg/day) www.atsdr.cdc.gov/ Toxicological Data Network (TOXNET) HSDB Last reviewed 15/09/2001 Ambient Air 3800 parts per trillion Mean concentration of 14 samples from the USA, location unspecified (equivalent to a concentration of 15.2μg/m³, or an MDI of 304μg/day) Brodzinsky R, Singh HB; Volatile Organic Chemicals in the Atmosphere: An Assessment of Available Data. SRI Inter Contract 68-02-3452. pp. 198 (1982) http://toxnet.nlm.nih.gov / 2 of 2 \\D4H0634J\Firth Consultants\projects\eic\EIC GAC\3rd phase\Final Proformas\EIC Proforma 1,1-dichloroethene25/08/2009
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