Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 ID inhal 1,1-Dichloroethene CAS Number: 75-35-4 Assessor A: Cheryl Davies, Delta-Simons Assessor B: Jennifer Stothert, Entec UK Ltd Final Review: Panel/SF Date: 08/04/2009 Date: 29/04/2009 Date: 25/08/2009 Recommended IDinhal none Units Justification Insufficient data Organisation Last Updated Non threshold effects Basis Health criteria type International Agency for Research on http://inchem.org/pages/iarc.html 13/04/1999 29/04/2009 Vinylidene chloride is not Cancer (IARC) classifiable as to its carcinogenicity to humans (Group 3). IPCS concise International Chemical Assessment Documents (CICADs) http://inchem.org/pages/cicads.html 2003 29/04/2009 Fairly extensive database on the genotoxicity Value Units Confidence rating Basis IPCS Environmental Health Criteria (EHC) Monographs http://inchem.org/pages/ehc.html 1990 29/04/2009 Genotoxicity has been observed in prokaryotic and eukaryotic cells in vitro. However, genotoxicity was not observed in the majority of tests carried out on mammals in vivo. Not given Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels USEPA Integrated Risk Information System (IRIS) http://www.rivm.nl/en/ Oct-93 29/04/2009 http://www.atsdr.cdc.gov/ May-94 29/04/2009 Mutagenic to bacteria; no chromosomal aberration in mammalian cells; DNA damage observed in mammalian cells; limited evidence for carcinogenicity in animals, inadequate evidence to humans. Several in vitro studies suggest that 1,1- dichloroethene, only in the presence of activating systems, is mutagenic in both prokarydc and eukatydc organisms. These results are consistent with the idea that a reactive metabolic intermediate(s), and not the http://epa.gov/iris/ 01/06/2002 29/04/2009 One bioassay by the inhalation route of exposure showed suggestive evidence of carcinogenicity for humans. EPA does not currently believe that the suggestive evidence of a tumor response provides sufficient weight of evidence to justify deriving an inhalation 7 of 8 \\D4H0634J\Firth Consultants\projects\eic\EIC GAC\3rd phase\Final Proformas\EIC Proforma 1,1-dichloroethene25/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,1-Dichloroethene ID inhal Organisation Study type Description Response Reference Web link International Agency for Research on Cancer (IARC) IPCS concise International Chemical Assessment Documents (CICADs) IPCS Environmental Health Criteria (EHC) Monographs Vinylidene chloride is not classifiable as to its carcinogenicity to humans (Group 3). http://www.inchem.org/documents/iarc/vol71/050-vinylchl.html http://www.inchem.org/documents/cicads/cicads/cicad51.htm http://inchem.org/documents/ehc/ehc/ehc100.htm#SubSectionNumber:1.4.4 Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels http://www.rivm.nl/bibliotheek/rapporten/679101010.pdf US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels USEPA Integrated Risk Information System (IRIS) http://www.epa.gov/ncea/iris/toxreviews/0039-tr.pdf 8 of 8 \\D4H0634J\Firth Consultants\projects\eic\EIC GAC\3rd phase\Final Proformas\EIC Proforma 1,1-dichloroethene25/08/2009
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