Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 ID oral 1,1-Dichloroethene CAS Number: 75-35-4 Assessor A: Cheryl Davies, Delta-Simons Assessor B: Jennifer Stothert, Entec UK Ltd Final Review: Panel/SF Date: 08/04/2009 Date: 29/04/2009 Date: 25/08/2009 Recommended IDoral none Units Justification Insufficient data Organisation Last Updated Non threshold effects Basis Health criteria type International Agency for Research on http://inchem.org/pages/iarc.html 13/04/1999 29/04/2009 Vinylidene chloride is not Cancer (IARC) classifiable as to its carcinogenicity to humans (Group 3). IPCS concise International Chemical Assessment Documents (CICADs) http://inchem.org/pages/cicads.html 2003 29/04/2009 Fairly extensive database on the genotoxicity Value Units Confidence rating Basis IPCS Environmental Health Criteria (EHC) Monographs http://inchem.org/pages/ehc.html 1990 29/04/2009 Genotoxicity has been observed in prokaryotic and eukaryotic cells in vitro. However, genotoxicity was not observed in the majority of tests carried out on mammals in vivo. Not given Health Canada Toxicological Values http://www.hc-sc.gc.ca/index_e.html 2005 29/04/2009 the weight of evidence for carcinogenicity and genotoxicity is limited, a mode of action for induction of effects involving direct interaction with genetic material cannot be precluded. US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels USEPA Integrated Risk Information System (IRIS) http://www.atsdr.cdc.gov/ May-94 29/04/2009 No studies were located regarding genotoxic effects in humans or animals after oral exposure http://epa.gov/iris/ 01/06/2002 29/04/2009 None of the bioassays by the oral route of exposure provide sufficient evidence that 1,1-DCE is a carcinogen 5 of 8 \\D4H0634J\Firth Consultants\projects\eic\EIC GAC\3rd phase\Final Proformas\EIC Proforma 1,1-dichloroethene25/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,1-Dichloroethene ID oral Organisation Study type Description Response Reference Web link International Agency for Research on Cancer (IARC) Vinylidene chloride is not classifiable as to its carcinogenicity to humans (Group 3). http://www.inchem.org/documents/iarc/vol71/050-vinylchl.html IPCS concise International Chemical Assessment Documents (CICADs) IPCS Environmental Health Criteria (EHC) Monographs http://www.inchem.org/documents/cicads/cicads/cicad51.htm http://inchem.org/documents/ehc/ehc/ehc100.htm#SubSectionNumber:1.4.4 Health Canada Toxicological Values US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels USEPA Integrated Risk Information System (IRIS) http://www.epa.gov/ncea/iris/toxreviews/0039-tr.pdf 6 of 8 \\D4H0634J\Firth Consultants\projects\eic\EIC GAC\3rd phase\Final Proformas\EIC Proforma 1,1-dichloroethene25/08/2009
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