Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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ID oral
1,1-Dichloroethene CAS Number: 75-35-4
Assessor A: Cheryl Davies,
Delta-Simons
Assessor B:
Jennifer Stothert,
Entec UK Ltd
Final Review: Panel/SF
Date: 08/04/2009 Date: 29/04/2009 Date: 25/08/2009
Recommended
IDoral
none
Units
Justification
Insufficient data
Organisation Last Updated Non threshold effects Basis Health criteria
type
International Agency for Research on http://inchem.org/pages/iarc.html 13/04/1999 29/04/2009 Vinylidene chloride is not
Cancer (IARC)
classifiable as to its
carcinogenicity to humans
(Group 3).
IPCS concise International Chemical
Assessment Documents (CICADs)
http://inchem.org/pages/cicads.html 2003 29/04/2009 Fairly extensive database
on the genotoxicity
Value Units Confidence rating
Basis
IPCS Environmental Health Criteria (EHC)
Monographs
http://inchem.org/pages/ehc.html 1990 29/04/2009 Genotoxicity has been
observed in prokaryotic
and eukaryotic cells in
vitro. However,
genotoxicity was not
observed in the majority
of tests carried out on
mammals in vivo.
Not given
Health Canada Toxicological Values http://www.hc-sc.gc.ca/index_e.html 2005 29/04/2009 the weight of evidence for
carcinogenicity and
genotoxicity is limited, a
mode of action for
induction of effects
involving direct
interaction with genetic
material cannot be
precluded.
US Agency for Toxic Substances and Disease
Registry (ATDSR) Toxicological Profiles and
Minimal Risk levels
USEPA Integrated Risk Information System
(IRIS)
http://www.atsdr.cdc.gov/ May-94 29/04/2009 No studies were located
regarding genotoxic
effects in humans or
animals after oral
exposure
http://epa.gov/iris/ 01/06/2002 29/04/2009 None of the bioassays by
the oral route of exposure
provide sufficient
evidence that 1,1-DCE is a
carcinogen
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