Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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1,1-Dichloroethene CAS Number: 75-35-4
Assessor A: Cheryl Davies,
Delta-Simons
Assessor B:
Jennifer Stothert,
Entec UK Ltd
Final Review: Panel/SF
Date: 08/04/2009 Date: 29/04/2009 Date: 25/08/2009
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
Oral
Inhalation
Dermal
Yes Yes No
No No No
No No Yes
No No No
Combine Oral
and Inhalation
TDIs
Yes
Justification
Insufficient data to assess non-threshold effects,
HCV based on threshold effects.
Insufficient data to assess non-threshold effects,
HCV based on threshold effects.
TDI oral
Recommended
TDIoral
Units
46 ug.kg-1.d-1
Justification
46 (or round to 50) as consensus value from the majority of sources (WHO, US EPA IRIS, CICADs). RIVM value discounted as it is provisional and based
on route to route extrapolation; ATSDR value discounted as based on 1992 IRIS recommendation which has subsequently been revised.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence
1.d-1
rating
International Agency for Research on http://inchem.org/pages/iarc.html 13/04/1999 16/03/2009
Cancer (IARC)
IPCS concise International Chemical http://inchem.org/pages/cicads.html 2003 20/03/2009 TDI 0.05 (rounded mg.kg-1.d-1
50 Uncertainty
Assessment Documents (CICADs)
up from 0.046)
that the lab
animal data
have
demonstrate
d the correct
target tissue
for humans
Basis Value Units UF UF description
BMD10 4.6 mg.kg-1.d-1 100 10 interspecies and 10 intraspecies
IPCS Environmental Health Criteria (EHC) http://inchem.org/pages/ehc.html 1990 20/03/2009 Not given Not given
Monographs
WHO Guidelines for drinking water Quality http://www.who.int/water_sanitation_healt 2006 16/03/2009 TDI 0.046 mg.kg-1.d-1 46 Not given BMD Not given Not given
h/dwq/guidelines/en
Dutch National Institute for Public Health http://www.rivm.nl/en/ 1998 20/03/2009 Oral Max. Permissible Risk
3 ug.kg-1bw-1.d-1 3 Provisional Not given
None
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
MPR TDI
value
(tentative
value based
on route to
route
extrapolation
)
Health Canada Toxicological Values http://www.hc-sc.gc.ca/index_e.html 2005 20/03/2009 5 mg.kg-1.d-1 Not given LOAEL
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
USEPA Integrated Risk Information System
(IRIS)
http://www.atsdr.cdc.gov/ May-94 16/03/2009 RfD 0.009 mg.kg-1.d-1 9 Not given;
based on
now
superseded
IRIS
recommenda
tion
LOAEL 9 mg.kg-1.d-1 1000 10 interspecies, 10 intraspecies, 10
LOAEL to NOAEL
http://epa.gov/iris/ 13/08/2002 16/03/2009 RfD 5.0 x10-2 mg.kg-1.d-1 50 Medium BMDL10 4.6 mg.kg-1.d-1 100 10 interspecies, 10 intraspecies
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